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Results for "

longer-half-life

" in MedChemExpress (MCE) Product Catalog:

52

Inhibitors & Agonists

30

Biochemical Assay Reagents

1

Peptides

2

Inhibitory Antibodies

2

Isotope-Labeled Compounds

28

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P99340
    Sotrovimab
    4 Publications Verification

    VIR 7831; GSK-4182136

    		 SARS-CoV Infection Cancer
    Sotrovimab (VIR 7831) is a human IgG1κ pan-sarbecovirus monoclonal antibody (mAb), neutralizes SARS-CoV-2, SARS-CoV-1, and multiple other sarbecoviruses. Sotrovimab is developed based on S309, exhibits a long half-life and great bioavailability in the respiratory mucosa. Sotrovimab could result in immune-mediated viral clearance and prevent progression of Covid-19 early in the course of disease .
    Sotrovimab
  • HY-W394903
    GS-829845

    		Drug Metabolite JAK Inflammation/Immunology
    GS-829845 is a is a major, active metabolite of Filgotinib (HY-18300). GS-829845 is a JAK1 preferential inhibitor but is approximately 10-fold less potent than the parent and with a longer half-life .
    GS-829845
  • HY-13859
    Clevudine
    1 Publications Verification

    L-FMAU

    		 HBV DNA/RNA Synthesis Orthopoxvirus Infection
    Clevudine (L-FMAU), a nucleoside analog of the unnatural L-configuration, has potent anti-HBV activity with long half-life, low toxicity. Clevudine is a non-competitive inhibitor that is not incorporated into the viral DNA but rather binds to the polymerase. Clevudine is active against cowpox virus respiratory infection in mice .
    Clevudine
  • HY-132242
    DL-Sulforaphane N-acetyl-L-cysteine

    SFN-NAC

    		 HDAC Apoptosis Drug Metabolite Cancer
    DL-Sulforaphane N-acetyl-L-cysteine (SFN-NAC) is an orally active HDAC inhibitor and metabolite of sulforaphane (HY-13755) with longer half-life and better blood-brain barrier permeability. DL-Sulforaphane N-acetyl-L-cysteine activates autophagy-mediated downregulation of α-tubulin expression through the ERK pathway and can be used in cancer research .
    DL-Sulforaphane N-acetyl-L-cysteine
  • HY-135774
    6-Hydroxybenzbromarone

    		Drug Metabolite Phosphatase Cardiovascular Disease
    6-Hydroxybenzbromarone is the major metabolite of Benzbromarone with a longer half-life and greater pharmacological potency than the parent compound. 6-Hydroxybenzbromarone is a protein Eyes Absent 3 (EYA3) inhibitor with an IC50 value of 21.5 μM. 6-Hydroxybenzbromarone is an anti-angiogenic agent, has strong inhibitory effects on cell migration, tubulogenesis, and angiogenic sprouting .
    6-Hydroxybenzbromarone
  • HY-W440702
    Cholesterol-PEG2000-NHS

    		Biochemical Assay Reagents Others
    Cholesterol-PEG2000-NHS is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG2000-NHS can be used in drug delivery research .
    Cholesterol-PEG2000-NHS
  • HY-W440697
    Cholesterol-PEG1000-NHS

    		Biochemical Assay Reagents Others
    Cholesterol-PEG1000-NHS is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG1000-NHS can be used in drug delivery research .
    Cholesterol-PEG1000-NHS
  • HY-123022
    Tomopenem

    CS-023; RO4908463; R-115685

    		 Bacterial Infection
    Tomopenem (CS-023; RO4908463; R-115685) is a longer-half-life parenteral carbapenem. Tomopenem shows broad activity against 63 reference species. The activity of tomopenem against 293 clinical isolates is potent (MIC90, 0.06 to 4 μg/mL). Antianaerobic activity .
    Tomopenem
  • HY-174445
    C199

    		PROTACs Histone Methyltransferase Apoptosis Cancer
    C199 is a PROTAC degrader targeting PRMT4 (DC50 = 106 nM). C199 shows high selectivity for PRMT4 over other protein arginile methyltransferases. C199 exhibits strong cell degradation ability. C199 induces apoptosis in MM cell lines. C199 efficiently clears PRMT4 protein via the VHL-proteasome pathway. C199 has a relatively long half-life and shows strong anti-multiple myeloma (MM) tumor activity (Pink: Target protein ligand (HY-111109); Blue: E3 ligase ligand (HY-112078), E3 ligase ligand + linker (HY-174474); black: Linker) .
    C199
  • HY-135842
    Aspoxicillin

    		Bacterial Antibiotic Infection
    Aspoxicillin is a broad-spectrum antimicrobial agent against 68 isolates of Actinobacillus pleuropneumoniae with an MIC90 value of <= 0.05 μg/ml. Aspoxicillin has a long half-life in mouse serum of 55 minutes .
    Aspoxicillin
  • HY-W440718
    Cholesterol-PEG1000-Mal

    		Biochemical Assay Reagents Others
    Cholesterol-PEG1000-Mal is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG1000-Mal can be used in drug delivery research .
    Cholesterol-PEG1000-Mal
  • HY-W440704
    Cholesterol-PEG5000-NHS

    		Biochemical Assay Reagents Others
    Cholesterol-PEG5000-NHS is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG5000-NHS can be used in drug delivery research .
    Cholesterol-PEG5000-NHS
  • HY-B1118S
    Secnidazole-d6

    RP-14539-d6; PM-185184-d6

    		 Isotope-Labeled Compounds Parasite Antibiotic Infection
    Secnidazole-d6 is the deuterium labeled Secnidazole. Secnidazole (RP-14539;PM-185184) is an orally active azole antibiotic with a longer half-life than metronidazole (HY-B0318). Secnidazole is against the vaginosis-associated bacteria and has the potential for bacterial vaginosis research .
    Secnidazole-d6
  • HY-159640
    NVP-FVP954

    		Parasite Infection
    NVP-FVP954 is a fast-acting antimalarial agent with potential for severe malaria. FVP954 has a high barrier to resistance, long half-life, and high solubility, making it suitable for intravenous administration .
    NVP-FVP954
  • HY-W591891
    Cholesterol-PEG1000-acid

    		Biochemical Assay Reagents Others
    Cholesterol-PEG1000-acid is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG1000-acid can be used in drug delivery research .
    Cholesterol-PEG1000-acid
  • HY-176715
    Kv7.2 activator-1

    		Potassium Channel Neurological Disease
    Kv7.2 activator-1 (Compound 8) is a Kv7.2/3 activator with an EC50 of 178 nM. Kv7.2 activator-1 has a long half-life of 120 minutes in HLM .
    Kv7.2 activator-1
  • HY-W440695
    Cholesterol-PEG3400-azide

    		Biochemical Assay Reagents Others
    Cholesterol-PEG3400-azide is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG3400-azide can be used in drug delivery research .
    Cholesterol-PEG3400-azide
  • HY-W440692
    Cholesterol-PEG5000-amine

    		Biochemical Assay Reagents Others
    Cholesterol-PEG5000-amine is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG5000-amine can be used in drug delivery research .
    Cholesterol-PEG5000-amine
  • HY-W440696
    Cholesterol-PEG5000-azide

    		Biochemical Assay Reagents Others
    Cholesterol-PEG5000-azide is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG5000-azide can be used in drug delivery research .
    Cholesterol-PEG5000-azide
  • HY-W591912
    Cholesterol-PEG1000-methoxy

    		Biochemical Assay Reagents Others
    Cholesterol-PEG1000-methoxy is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG1000-methoxy can be used in drug delivery research .
    Cholesterol-PEG1000-methoxy
  • HY-W440723
    Cholesterol-PEG2000-Thiol

    		Biochemical Assay Reagents Others
    Cholesterol-PEG2000-Thiol is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG2000-Thiol can be used in drug delivery research .
    Cholesterol-PEG2000-Thiol
  • HY-W440707
    Cholesterol-PEG3400-alcohol

    		Biochemical Assay Reagents Others
    Cholesterol-PEG3400-alcohol is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG3400-alcohol can be used in drug delivery research .
    Cholesterol-PEG3400-alcohol
  • HY-W440721
    Cholesterol-PEG5000-Mal

    		Biochemical Assay Reagents Others
    Cholesterol-PEG5000-Mal is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG5000-Mal can be used in drug delivery research .
    Cholesterol-PEG5000-Mal
  • HY-W440693
    Cholesterol-PEG1000-azide

    		Biochemical Assay Reagents Others
    Cholesterol-PEG1000-azide is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG1000-azide can be used in drug delivery research .
    Cholesterol-PEG1000-azide
  • HY-W440691
    Cholesterol-PEG3400-amine

    		Biochemical Assay Reagents Others
    Cholesterol-PEG3400-amine is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG3400-amine can be used in drug delivery research .
    Cholesterol-PEG3400-amine
  • HY-W440705
    Cholesterol-PEG1000-alcohol

    		Biochemical Assay Reagents Others
    Cholesterol-PEG1000-alcohol is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG1000-alcohol can be used in drug delivery research .
    Cholesterol-PEG1000-alcohol
  • HY-W440720
    Cholesterol-PEG3400-Mal

    		Biochemical Assay Reagents Others
    Cholesterol-PEG3400-Mal is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG3400-Mal can be used in drug delivery research .
    Cholesterol-PEG3400-Mal
  • HY-W440708
    Cholesterol-PEG5000-alcohol

    		Biochemical Assay Reagents Others
    Cholesterol-PEG5000-alcohol is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG5000-alcohol can be used in drug delivery research .
    Cholesterol-PEG5000-alcohol
  • HY-W440703
    Cholesterol-PEG3400-NHS

    		Biochemical Assay Reagents Others
    Cholesterol-PEG3400-NHS is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG3400-NHS can be used in drug delivery research .
    Cholesterol-PEG3400-NHS
  • HY-W440712
    Cholesterol-PEG3400-Biotin

    		Biochemical Assay Reagents Others
    Cholesterol-PEG3400-Biotin is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG3400-Biotin can be used in drug delivery research .
    Cholesterol-PEG3400-Biotin
  • HY-135842R
    Aspoxicillin (Standard)

    		Reference Standards Bacterial Antibiotic Infection
    Aspoxicillin (Standard) is the analytical standard of Aspoxicillin. This product is intended for research and analytical applications. Aspoxicillin is a broad-spectrum antimicrobial agent against 68 isolates of Actinobacillus pleuropneumoniae with an MIC90 value of <= 0.05 μg/ml. Aspoxicillin has a long half-life in mouse serum of 55 minutes .
    Aspoxicillin (Standard)
  • HY-B1118S1
    Secnidazole-13C2, 15N2

    RP-14539-13C2, 15N2; PM-185184-13C2, 15N2

    		 Isotope-Labeled Compounds Parasite Antibiotic Infection
    Secnidazole- 13C2, 15N2 is the 13C2, 15N2 labeled Secnidazole. Secnidazole (RP-14539;PM-185184) is an orally active azole antibiotic with a longer half-life than metronidazole (HY-B0318). Secnidazole is against the vaginosis-associated bacteria and has the potential for bacterial vaginosis research.
    Secnidazole-13C2, 15N2
  • HY-105110
    SCH 39304

    SM-8668

    		 Fungal Infection
    SM-8668 is an effective orally active antifungal agent, with median effective doses (ED50) of 0.18, 3.7, and 5.9 mg/kg for systemic candidiasis, aspergillosis, and cryptococcosis in mice, respectively. Pharmacokinetic studies in mice and rats indicate that SM-8668 has a long half-life and a high total exposure. SM-8668 can be used in anti-infective research .
    SCH 39304
  • HY-162940
    MerTK/Axl-IN-1

    		TAM Receptor Inflammation/Immunology Cancer
    MerTK/Axl-IN-1 (Compound A-910) is a potent and selective dual MerTK/Axl inhibitor, with IC50s of 4.2 and 8.8 nM in Ba/F3, and 0.2 and 0.9 nM in HTRF. MerTK/Axl-IN-1 results in pMerTK inhibition in vivo. MerTK/Axl-IN-1 has long half-life, high oral exposure and bioavailability .
    MerTK/Axl-IN-1
  • HY-162583
    PDE4-IN-17

    		Phosphodiesterase (PDE) Inflammation/Immunology
    PDE4-IN-17 (compound 4e) is a potent PDE4 inhibitor. PDE4-IN-17 inhibits PDE4B and PDE4D with IC50s of 10.0 and 15.2 nM, respectively. PDE4-IN-17 has good oral bioavailability (F=66%) and longer half-life (t1/2=2.0 h) in SD rats .
    PDE4-IN-17
  • HY-169064
    HIV-1 inhibitor-75

    		HIV Reverse Transcriptase Infection
    HIV-1 inhibitor-75 is a human immunodeficiency virus 1 (HIV-1) inhibitor, with an EC50 value ranging from 0.0039 to 0.338 μM. The binding target of HIV-1 inhibitor-75 is reverse transcriptase, with an IC50 value of 0.055 μM. HIV-1 inhibitor-75 shows good in vitro metabolic stability, exhibiting moderate clearance rates and a longer half-life in human plasma and liver microsomes .
    HIV-1 inhibitor-75
  • HY-120812
    HIV-IN-11

    		HIV Protease Infection
    HIV-IN-11 is part of the hydroxylaminoglutaramide (HAPA) transition state isomeric series of HIV protease inhibitors and is a potent and selective inhibitor of HIV-1 protease. HIV-IN-11 competitively inhibits HIV-1 PR (Ki: 0.049 nM) and potently inhibits replication of HIV(IIIb)-infected MT4 lymphocytes at concentrations of 25.0-50.0 nM. HIV-IN-11 displays a longer half-life than indinavir sulfate in animal models and serves as a promising second-generation HIV protease inhibitor .
    HIV-IN-11
  • HY-164477
    FL442

    		Androgen Receptor Cancer
    FL442 is an Androgen Receptor (AR) modulator. FL442 exhibits strong inhibitory effects in AR-dependent prostate cancer cells, showing similar inhibitory efficiency to traditional antiandrogen drugs Bicalutamide (HY-14249) and Enzalutamide (HY-70002), while maintaining antiandrogenic activity against the AR mutant F876L, which is highly resistant to Enzalutamide. Pharmacokinetic studies of FL442 in mice reveal a long half-life (8 hours), good targeting (prostate tissue), and metabolic stability, and it effectively inhibits LNCaP tumor growth at low plasma concentrations (30 ng/mL) .
    FL442
  • HY-W331198
    Tralopyril

    		Insecticide Ferroptosis Infection
    Tralopyril is an orally active, blood-brain barrier-penetrating antifouling insecticide and endocrine disruptor. By interfering with the thyroid hormone system and mitochondrial oxidative phosphorylation, Tralopyril downregulates the transcription of genes such as TRHR, Nkx2.1, TRα and induces ferroptosis. Tralopyril disrupts amino acid, energy and lipid metabolism, exhibits significant skeletal and reproductive toxicity, and causes developmental damage. Tralopyril has a long half-life in vivo and wide tissue distribution, posing potential risks to aquatic organisms and human health. Tralopyril shows species specificity in in vitro liver microsomal metabolism, exerts lethal effects on target insects and laboratory animals, and is commonly used in studies of chlorfenapyr poisoning and related toxic mechanisms .
    Tralopyril
  • HY-W440699
    Cholesterol-PEG3400-acid

    		Biochemical Assay Reagents Others
    Cholesterol-PEG3400-acid is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG3400-acid can be used in drug delivery research .
    Cholesterol-PEG3400-acid
  • HY-W440700
    Cholesterol-PEG5000-acid

    		Biochemical Assay Reagents Others
    Cholesterol-PEG5000-acid is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG5000-acid can be used in drug delivery research .
    Cholesterol-PEG5000-acid
  • HY-W591914
    Cholesterol-PEG5000-methoxy

    		Biochemical Assay Reagents Others
    Cholesterol-PEG5000-methoxy is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG5000-methoxy can be used in drug delivery research .
    Cholesterol-PEG5000-methoxy
  • HY-W440726
    Cholesterol-PEG1000-Vinylsulfone

    		Biochemical Assay Reagents Others
    Cholesterol-PEG1000-Vinylsulfone is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG1000-Vinylsulfone can be used in drug delivery research .
    Cholesterol-PEG1000-Vinylsulfone
  • HY-W440728
    Cholesterol-PEG3400-Vinylsulfone

    		Biochemical Assay Reagents Others
    Cholesterol-PEG3400-Vinylsulfone is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG3400-Vinylsulfone can be used in drug delivery research .
    Cholesterol-PEG3400-Vinylsulfone
  • HY-W440717
    Cholesterol-PEG5000-Folate

    		Biochemical Assay Reagents Others
    Cholesterol-PEG5000-Folate is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG5000-Folate can be used in drug delivery research .
    Cholesterol-PEG5000-Folate
  • HY-W440716
    Cholesterol-PEG3400-Folate

    		Biochemical Assay Reagents Others
    Cholesterol-PEG3400-Folate is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG3400-Folate can be used in drug delivery research .
    Cholesterol-PEG3400-Folate
  • HY-W440725
    Cholesterol-PEG5000-Thiol

    		Biochemical Assay Reagents Others
    Cholesterol-PEG5000-Thiol is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG5000-Thiol can be used in drug delivery research .
    Cholesterol-PEG5000-Thiol
  • HY-W440713
    Cholesterol-PEG5000-Biotin

    		Biochemical Assay Reagents Others
    Cholesterol-PEG5000-Biotin is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG5000-Biotin can be used in drug delivery research .
    Cholesterol-PEG5000-Biotin
  • HY-W440709
    Cholesterol-PEG10000-alcohol

    		Biochemical Assay Reagents Others
    Cholesterol-PEG10000-alcohol is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG10000-alcohol can be used in drug delivery research .
    Cholesterol-PEG10000-alcohol
  • HY-W440729
    Cholesterol-PEG5000-Vinylsulfone

    		Biochemical Assay Reagents Others
    Cholesterol-PEG5000-Vinylsulfone is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG5000-Vinylsulfone can be used in drug delivery research .
    Cholesterol-PEG5000-Vinylsulfone

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