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Results for "

melanin-concentrating

" in MedChemExpress (MCE) Product Catalog:

By Targets:	MCHR1 (GPR24) (28) 5-HT Receptor (2) Cytochrome P450 (2) Endogenous Metabolite (1) Melanocortin Receptor (1) Potassium Channel (1) Reference Standards (2)
By Research Areas:	Cancer (1) Cardiovascular Disease (2) Endocrinology (12) Metabolic Disease (19) Neurological Disease (14)

Inhibitors & Agonists

Peptides

Recombinant Proteins

Targets Recommended: MCHR1 (GPR24)

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-U00257

AZD1979	MCHR1 (GPR24)	Metabolic Disease Endocrinology
AZD1979 is a Melanin-concentrating hormone receptor 1 (MCHr1) antagonist with an IC₅₀ of ~12 nM.

HY-P1205A

MCH(human, mouse, rat) TFA 1 Publications Verification melanin-concentrating hormone(human, mouse, rat) TFA	MCHR1 (GPR24)	Neurological Disease Metabolic Disease
MCH (human, mouse, rat) TFA is a cyclic neuropeptide mainly synthesized by neurons in the lateral hypothalamic area. MCH (human, mouse, rat) TFA also serves as an endogenous ligand for the melanin-concentrating hormone receptor (MHC receptor), with a binding IC₅₀ of 0.3 nM and 1.5 nM for human MCH-1R and MCH-2R, respectively; its functional EC₅₀ values are 3.9 nM and 88.7 nM. MCH (human, mouse, rat) TFA acts not only as an orexigenic signal but also as a key integrating and regulatory hormone for energy homeostasis and sleep-wake cycles. MCH (human, mouse, rat) TFA can be used in studies related to obesity, sleep disorders, and other associated conditions .

HY-107625A

SNAP 94847 hydrochloride 2 Publications Verification	MCHR1 (GPR24)	Neurological Disease
SNAP 94847 hydrochloride is a novel, high affinity selective melanin-concentrating hormonereceptor1 (MCHR1) antagonist with (K_i= 2.2 nM, K_d=530 pM), it displays >80-fold and >500-fold selectivity over MCHα1A and MCHD2 receptors respectively. SNAP 94847 hydrochloride binds with high affinity to the mouse and rat MCHR1 with minimal cross-reactivity to other GPCR, ion channels, enzymes, and transporters .

HY-12433

BMS-819881	MCHR1 (GPR24) Cytochrome P450	Metabolic Disease Endocrinology
BMS-819881 is a melaninconcentrating hormone receptor 1 (MCHR1) antagonist, which binds rat MCHR1 with a K_i of 7 nM. BMS-819881 also is selective and potent for CYP3A4 activity with an EC₅₀ of 13 μM.

HY-100318

MCHR1 antagonist 5	MCHR1 (GPR24)	Metabolic Disease
MCHR1 antagonist 5 (Compound 80) is a melanin-concentrating hormone receptor 1 (MCHR1) antagonist. MCHR1 antagonist 5 can be uesd for the study of a variety of metabolic, feeding and sexual disorders .

HY-11083

GW-803430 GW-3430	MCHR1 (GPR24)	Metabolic Disease
GW-803430 (GW-3430) is a potent and selective melanin-concentrating hormone receptor 1 (MCH R1) antagonist with a pIC₅₀ of 9.3. GW-803430 is orally active in an animal model of obesity .

HY-111398

ALB-127158(a) 1 Publications Verification	MCHR1 (GPR24)	Metabolic Disease Endocrinology
ALB-127158(a) is a potent and selective melanin concentrating hormone 1 (MCH₁) receptor antagonist.

HY-P1205

MCH(human, mouse, rat) 1 Publications Verification melanin-concentrating hormone(human, mouse, rat)	MCHR1 (GPR24)	Neurological Disease Metabolic Disease
MCH (human, mouse, rat) is a cyclic neuropeptide mainly synthesized by neurons in the lateral hypothalamic area. MCH (human, mouse, rat) also serves as an endogenous ligand for the melanin-concentrating hormone receptor (MHC receptor), with a binding IC₅₀ of 0.3 nM and 1.5 nM for human MCH-1R and MCH-2R, respectively; its functional EC₅₀ values are 3.9 nM and 88.7 nM. MCH (human, mouse, rat) acts not only as an orexigenic signal but also as a key integrating and regulatory hormone for energy homeostasis and sleep-wake cycles. MCH (human, mouse, rat) can be used in studies related to obesity, sleep disorders, and other associated conditions .

HY-P1525

Melanin Concentrating Hormone, salmon MCH (salmon)	MCHR1 (GPR24)	Cardiovascular Disease Neurological Disease Metabolic Disease Endocrinology
Melanin Concentrating Hormone, salmon is a 19-amino-acid neuropeptide initially identified in the pituitary gland of teleost fish, which regulates food intake, energy balance, sleep state, and the cardiovascular system. Melanin-concentrating hormone is a ligand for an orphan G protein-coupled receptor (SLC-1/GPR24) and MCHR2.

HY-P1525A

Melanin Concentrating Hormone, salmon TFA MCH (salmon) TFA	MCHR1 (GPR24)	Cardiovascular Disease Neurological Disease Metabolic Disease Endocrinology
Melanin Concentrating Hormone, salmon TFA (MCH (salmon) TFA) is a 19-amino-acid neuropeptide initially identified in the pituitary gland of teleost fish, which regulates food intake, energy balance, sleep state, and the cardiovascular system. Melanin-concentrating hormone is a ligand for an orphan G protein-coupled receptor (SLC-1/GPR24) and MCHR2.

HY-107624

ATC0175 1 Publications Verification	MCHR1 (GPR24)	Neurological Disease
ATC0175 is a potent, selective and orally active melanin-concentrating hormone 1 recepter antagonist with IC₅₀s of 13.5, >10000 nM for MCH1R, MCH2R, respectively. ATC0175 shows antidepressant effects and anxiolytic effects in animal models. ATC0175 has the potential for the research of depression and/or anxiety disorders .

HY-100321

MCHR1 antagonist 2	MCHR1 (GPR24) Potassium Channel	Metabolic Disease Endocrinology
MCHR1 antagonist 2 is an antagonist of melanin concentrating hormone receptor 1, with an IC₅₀ of 65 nM; MCHR1 antagonist 2 also inhibits hERG, with an IC₅₀ of 4.0 nM in IMR-32 cells .

HY-107626

ATC0065	MCHR1 (GPR24) 5-HT Receptor	Neurological Disease
ATC0065 is a potent, selective and orally active melanin-concentrating hormone (MCH) receptor 1 (MCHR1) antagonist with an IC₅₀ of 15.7 nM for human MCHR1. ATC0065 does not exhibits significant activity for MCHR2. ATC0065 has anxiolytic and antidepressant activities .

HY-P4745

hMCH-1R antagonist 1	MCHR1 (GPR24)	Metabolic Disease
hMCH-1R antagonist 1 (Compound 30) is an effective and selective antagonist of human melanin-concentrating hormone receptor 1 (hMCHR1) with an K_B value of 3.6 nM. HMCH-1R antagonist 1 can bind to hMCHR1 and hMCHR2 with IC₅₀ values of 65 nM and 49 nM, respectively. HMCH-1R antagonistist 1 can be used for metabolic research .

HY-W039283

MCH-1 antagonist 2	MCHR1 (GPR24)	Neurological Disease Cancer
MCH-1 antagonist 2 (l-BROMO-2,4-DIFLUORO-5-NITROBEN-ZENE) is a melanin concentrating hormone-1 (MCH1) receptor-selective 4-aryl piperidine. MCH-1 antagonist 2 can be used for the research of depression, anxiety, obesity, urge incontinence, urinary incontinence, major depression, bipolar disorder, agoraphobia, specific phobia, social phobia, obsessive-compulsive disorder, post-traumatic stress disorder, acute stress disorder, urinary frequency, urinary urgency, nocturia, enuresis, bulimia, bulimia nervosa, anorexia nervosa, major depressive disorder, dysthymic disorder, bipolar 1 and 2 disorders, schizoaffective disorder, cognitive disorders with depressed mood, personality disorders, insomnia, hypersomnia, narcolepsy, circadian rhythm sleep disorder, nightmare disorder, sleep terror disorder, sleepwalking disorder, panic disorder, social anxiety disorder, generalized anxiety disorder, overactive bladder .

HY-107626A

ATC0065 free base	MCHR1 (GPR24) 5-HT Receptor	Neurological Disease
ATC0065 free base is a potent, selective and orally active melanin-concentrating hormone (MCH) receptor 1 (MCHR1) antagonist with an IC₅₀ of 15.7 nM for human MCHR1. ATC0065 free base does not exhibits significant activity for MCHR2. ATC0065 free base has anxiolytic and antidepressant activities .

HY-107625

SNAP 94847	MCHR1 (GPR24)	Neurological Disease Endocrinology
SNAP 94847 is a novel, high affinity selective melanin-concentrating hormonereceptor1 (MCHR1) antagonist with (K_i= 2.2 nM, K_d=530 pM), it displays >80-fold and >500-fold selectivity over MCHα1A and MCHD2 receptors respectively. SNAP 94847 binds with high affinity to the mouse and rat MCHR1 with minimal cross-reactivity to other GPCR, ion channels, enzymes, and transporters .

HY-136152

MCHR1 antagonist 3	MCHR1 (GPR24)	Metabolic Disease Endocrinology
MCHR1 antagonist 3 is a potent the melanin-concentrating hormone receptor-1 (MCHR1) antagonist. MCHR1 antagonist 3 is used to regulate energy metabolism .

HY-P1869

Neuropeptide EI, rat	MCHR1 (GPR24) Melanocortin Receptor	Neurological Disease Endocrinology
Neuropeptide EI, rat displays functional melanin concentrating hormone (MCH)-antagonist and melanocyte-stimulating hormone (MSH) agonist activity in different behavioral paradigms .

HY-100331

MCH-1 antagonist 1	MCHR1 (GPR24) Cytochrome P450	Metabolic Disease Endocrinology
MCH-1 antagonist 1 is a potent melanin concentrating hormone (MCH-1) antagonist with a K_i of 2.6 nM. MCH-1 antagonist 1 also inhibits CYP3A4 with an IC₅₀ of 10 μM.

HY-100308

SB-568849	MCHR1 (GPR24)	Metabolic Disease Endocrinology
SB-568849 is a melanin-concentrating hormone receptor 1 (MCH R1) antagonist with a pK_i of 7.7.

HY-11085

T-226296	MCHR1 (GPR24)	Metabolic Disease
T-226296 is an oral active and selective melanin-concentrating hormone receptor antagonist with the IC₅₀ values of 5.5 nM and 8.6 nM for human SLC-1 and rat SLC-1, respectively. T-226296 can be used for study of obesity and insulin resistance .

HY-116031

ATC0175 free base	MCHR1 (GPR24)	Metabolic Disease
ATC0175 (free base) is a potent and selective antagonist of melanin-concentrating hormone receptor 1 (MCH-R1) with an IC₅₀ value of 3.4 nM, as well as good selectivity over the Y5 and the α_2A receptors. ATC0175 (free base) is promising for research of obesity .

HY-U00353

MCHR1 antagonist 1	MCHR1 (GPR24)	Metabolic Disease Endocrinology
MCHR1 antagonist 1 is a selective antagonist of melanin concentrating hormone-1 (MCH1) receptor, with a K_b of 1 nM and a K_i of 4 nM at human MCH1, and may be used to reduce the body mass.

HY-11084

SNAP-7941	Endogenous Metabolite	Neurological Disease
SNAP-7941 is a selective antagonist with anxiolytic, antidepressant and appetite suppressant activities. SNAP-7941 showed promising biological activity in initial animal studies. SNAP-7941 targets the melanin concentrating hormone receptor MCH1 and has significant inhibitory potential. SNAP-7941 was shown to inhibit the centrally induced MCH-induced drinking effect in in vivo studies .

HY-119015

MCHR1 antagonist 6	MCHR1 (GPR24)	Metabolic Disease
MCHR1 antagonist 6 is a melanin-concentrating hormone receptor 1 (MCHR1) antagonist. MCHR1 antagonist 6 interacts with receptor residue D123 via its central basic group, and forms hydrogen bonds with receptor residue Q127 via its 2-amino-quinoline portion. MCHR1 antagonist 6 can be used for the research of obesity .

HY-185478

NGD-4715	MCHR1 (GPR24)	Metabolic Disease
NGD-4715 is an orally effective melanin-concentrating hormone receptor 1 (MCHR1) antagonist with IC₅₀ and K_i values of 10.6 nM and 5.9 nM, respectively. NGD-4715 acts as an inhibitor of food intake, a body weight regulator and a metabolic regulator, and reduces food intake, body weight gain and blood glucose levels in diet-induced obese rats. NGD-4715 is applicable to obesity-related research .

HY-107624R

ATC0175 (Standard)	Reference Standards MCHR1 (GPR24)	Neurological Disease
ATC0175 (Standard) is the analytical standard of ATC0175 (HY-107624). This product is intended for research and analytical applications. ATC0175 is a potent, selective and orally active melanin-concentrating hormone 1 recepter antagonist with IC₅₀s of 13.5, >10000 nM for MCH1R, MCH2R, respectively. ATC0175 shows antidepressant effects and anxiolytic effects in animal models. ATC0175 has the potential for the research of depression and/or anxiety disorders .

HY-107625AR

SNAP 94847 hydrochloride (Standard)	Reference Standards MCHR1 (GPR24)	Neurological Disease
SNAP 94847 hydrochloride (Standard) is the analytical standard of SNAP 94847 (hydrochloride) (HY-107625A). This product is intended for research and analytical applications. SNAP 94847 hydrochloride is a novel, high affinity selective melanin-concentrating hormonereceptor1 (MCHR1) antagonist with (K_i= 2.2 nM, K_d=530 pM), it displays >80-fold and >500-fold selectivity over MCHα1A and MCHD2 receptors respectively. SNAP 94847 hydrochloride binds with high affinity to the mouse and rat MCHR1 with minimal cross-reactivity to other GPCR, ion channels, enzymes, and transporters .

Cat. No.	상품명	Target	Research Area

HY-P1205A

MCH(human, mouse, rat) TFA 1 Publications Verification melanin-concentrating hormone(human, mouse, rat) TFA	MCHR1 (GPR24)	Neurological Disease Metabolic Disease
MCH (human, mouse, rat) TFA is a cyclic neuropeptide mainly synthesized by neurons in the lateral hypothalamic area. MCH (human, mouse, rat) TFA also serves as an endogenous ligand for the melanin-concentrating hormone receptor (MHC receptor), with a binding IC₅₀ of 0.3 nM and 1.5 nM for human MCH-1R and MCH-2R, respectively; its functional EC₅₀ values are 3.9 nM and 88.7 nM. MCH (human, mouse, rat) TFA acts not only as an orexigenic signal but also as a key integrating and regulatory hormone for energy homeostasis and sleep-wake cycles. MCH (human, mouse, rat) TFA can be used in studies related to obesity, sleep disorders, and other associated conditions .

HY-P1205

MCH(human, mouse, rat) 1 Publications Verification melanin-concentrating hormone(human, mouse, rat)	MCHR1 (GPR24)	Neurological Disease Metabolic Disease
MCH (human, mouse, rat) is a cyclic neuropeptide mainly synthesized by neurons in the lateral hypothalamic area. MCH (human, mouse, rat) also serves as an endogenous ligand for the melanin-concentrating hormone receptor (MHC receptor), with a binding IC₅₀ of 0.3 nM and 1.5 nM for human MCH-1R and MCH-2R, respectively; its functional EC₅₀ values are 3.9 nM and 88.7 nM. MCH (human, mouse, rat) acts not only as an orexigenic signal but also as a key integrating and regulatory hormone for energy homeostasis and sleep-wake cycles. MCH (human, mouse, rat) can be used in studies related to obesity, sleep disorders, and other associated conditions .

HY-P1525

Melanin Concentrating Hormone, salmon MCH (salmon)	MCHR1 (GPR24)	Cardiovascular Disease Neurological Disease Metabolic Disease Endocrinology
Melanin Concentrating Hormone, salmon is a 19-amino-acid neuropeptide initially identified in the pituitary gland of teleost fish, which regulates food intake, energy balance, sleep state, and the cardiovascular system. Melanin-concentrating hormone is a ligand for an orphan G protein-coupled receptor (SLC-1/GPR24) and MCHR2.

HY-P1525A

Melanin Concentrating Hormone, salmon TFA MCH (salmon) TFA	MCHR1 (GPR24)	Cardiovascular Disease Neurological Disease Metabolic Disease Endocrinology
Melanin Concentrating Hormone, salmon TFA (MCH (salmon) TFA) is a 19-amino-acid neuropeptide initially identified in the pituitary gland of teleost fish, which regulates food intake, energy balance, sleep state, and the cardiovascular system. Melanin-concentrating hormone is a ligand for an orphan G protein-coupled receptor (SLC-1/GPR24) and MCHR2.

HY-P4745

hMCH-1R antagonist 1	MCHR1 (GPR24)	Metabolic Disease
hMCH-1R antagonist 1 (Compound 30) is an effective and selective antagonist of human melanin-concentrating hormone receptor 1 (hMCHR1) with an K_B value of 3.6 nM. HMCH-1R antagonist 1 can bind to hMCHR1 and hMCHR2 with IC₅₀ values of 65 nM and 49 nM, respectively. HMCH-1R antagonistist 1 can be used for metabolic research .

HY-P1869

Neuropeptide EI, rat	MCHR1 (GPR24) Melanocortin Receptor	Neurological Disease Endocrinology
Neuropeptide EI, rat displays functional melanin concentrating hormone (MCH)-antagonist and melanocyte-stimulating hormone (MSH) agonist activity in different behavioral paradigms .

Cat. No.	Compare	상품명	Species	Source	Image

HY-P71439

	ZMYND19 Protein, Human (His) Zinc Finger MYND Domain-Containing Protein 19; melanin-concentrating Hormone Receptor 1-Interacting Zinc Finger Protein; MCH-R1-Interacting Zinc Finger Protein; ZMYND19; MIZIP	Human	E. coli
	ZMYND19 Protein, implicated in GPR24/MCH-R1 signaling, suggests a role in modulating the associated pathways. Its interaction with GPR24/MCH-R1 indicates regulatory involvement. Mechanisms and downstream effects of ZMYND19 in GPR24/MCH-R1 signaling require further elucidation. Exploring ZMYND19's functions may provide insights into its role in cellular responses, offering potential interventions in G protein-coupled receptor pathways. ZMYND19 Protein, Human (His) is the recombinant human-derived ZMYND19 protein, expressed by E. coli , with N-6*His labeled tag.

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