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Results for "

opioid+peptide

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amino Acid Derivatives (1) Aminopeptidase (3) Androgen Receptor (2) Angiotensin-converting Enzyme (ACE) (1) Apoptosis (2) Arrestin (1) Caspase (2) CXCR (1) Endogenous Metabolite (4) Enteropeptidase (2) ERK (4) MMP (2) mTOR (2) Neprilysin (1) Opioid Receptor (36)
By Research Areas:	Cancer (1) Cardiovascular Disease (1) Inflammation/Immunology (2) Metabolic Disease (6) Neurological Disease (33)

Inhibitors & Agonists

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P1333

Dynorphin A 1 Publications Verification	Opioid Receptor Apoptosis Caspase Endogenous Metabolite	Neurological Disease
Dynorphin A is an endogenous opioid peptide involved in inhibitory neurotransmission in the central nervous system (CNS). Dynorphin A is a highy potent *kappa opioid* receptor (KOR)** agonist, and is also an agonist for other opioid receptors, such as mu (MOR) and delta (DOR). Dynorphin A can induce neuronal death, and can be used in the research of neurological disease .

HY-P0179

β-Casomorphin, bovine β-Casomorphin-7 (bovine); Bovine β-casomorphin-7	Opioid Receptor	Neurological Disease Metabolic Disease
β-Casomorphin, bovine (β-Casomorphin-7 (bovine) ) is a *opioid* peptide with an IC₅₀ of 14 μM in an Opioid receptors binding assay .

HY-P1334

DPDPE 1 Publications Verification	Opioid Receptor	Neurological Disease
DPDPE, an opioid peptide, is a selective *δ-opioid* receptor?(DOR)** agonist?with anticonvulsant effects .

HY-W345510

Opiorphin	Neprilysin	Neurological Disease
Opiorphin, an opioid peptide, is a potent enkephalin-inactivating zinc ectopeptidases in human inhibitor. Opiorphin inhibits two enkephalin-catabolizing ectoenzymes, human neutral ecto-endopeptidase, hNEP (EC 3.4.24.11) with an IC₅₀ value of 11 μM, and human ecto-aminopeptidase, hAP-N (EC 3.4.11.2). Opiorphin displays potent analgesic activity by activating endogenous opioid-dependent transmission .

HY-P2159

Dynorphin A (1-8)	Opioid Receptor Endogenous Metabolite	Neurological Disease
Dynorphin A (1-8) is a ligand with preference for the *κ-opioid* receptor, and its IC₅₀** value against human placental κ-opioid receptor is 330 nM. Dynorphin A (1-8) mediates neuroprotective effects by inhibiting oxidative stress, suppressing apoptosis, and competitively displacing the binding of κ partial agonists. Dynorphin A (1-8) is the dominant opioid peptide in human placental villi and tissue extracts; it undergoes rapid hydrolysis and can enter the central nervous system via intranasal administration. Dynorphin A (1-8) can be used in studies related to ischemic stroke .

HY-P1596

Gluten Exorphin C	Opioid Receptor	Neurological Disease
Gluten exorphin C is an opioid peptide derived from wheat gluten. Its IC₅₀ values are 40 μM and 13.5 μM for μ opioid and δ opioid activities in the GPI and MVD assays, respectively.

HY-P3513

β-Neo-Endorphin	ERK MMP	Neurological Disease
β-Neo-Endorphin is an endogenous opioid peptide. β-Neo-Endorphin is a hypothalamic “big” Leu-enkephalin of porcine origin. β-Neo-Endorphin shows activation of the Erk1/2, MMP-2 and MMP-9 .

HY-P1334A

DPDPE TFA 1 Publications Verification	Opioid Receptor	Neurological Disease
DPDPE TFA, an opioid peptide, is a selective *δ-opioid* receptor (DOR)** agonist with anticonvulsant effects .

HY-P1742

Gluten Exorphin B5	Opioid Receptor	Metabolic Disease
Gluten Exorphin B5 is an exogenous opioid peptides derived from wheat gluten, acts on opioid receptor, increases postprandial plasma insulin level in rats .

HY-W000665

2,6-Dimethyl-L-tyrosine Dmt	Opioid Receptor	Neurological Disease
2,6-Dimethyl-L-tyrosine (Dmt) is a tyrosine derivative that enhances receptor affinity, functional bioactivity and in vivo analgesia of *opioid peptides* .

HY-P1481A

β-Casomorphin, human TFA Human β-casomorphin 7 TFA	Opioid Receptor	Neurological Disease Metabolic Disease
β-Casomorphin, human TFA (Human β-casomorphin 7 TFA) is an opioid peptide, acts as an agonist of opioid receptor .

HY-P2626

[D-Ala2]-Met-Enkephalin	Opioid Receptor	Neurological Disease
[D-Ala2]-Met-Enkephalin, an opioid peptide, is a potent *opioid* agonist. [D-Ala2]-Met-Enkephalin inhibits ACh-induced and suckling-induced oxytocin (OT) release .

HY-P1866A

β-Endorphin, equine TFA 1 Publications Verification	Opioid Receptor	Neurological Disease
β-Endorphin, equine TFA is an endogenous opioid peptide, which binds at high affinity to both *μ/δ opioid* receptors**. β-Endorphin, equine TFA has analgesic properties .

HY-P3550

β-Lipotropin (60-65) β-LPH (60-65); [Arg0] Met-Enkephalin	Opioid Receptor	Neurological Disease
β-Lipotropin (60-65) (β-LPH (60-65)), an opioid peptide, is a potent *opioid* agonist .

HY-P3555

D-Ala-Gly-Phe-Met-NH2	Opioid Receptor	Others
D-Ala-Gly-Phe-Met-NH2, an opioid peptide, is a potent opiate δ-receptor agonist .

HY-P3548

[D-Ala2]-Met-Enkephalinamide	Opioid Receptor	Neurological Disease
[D-Ala2]-Met-Enkephalinamide, an opioid peptide, is a potent *opioid* agonist. [D-Ala2]-Met-Enkephalinamide decreases bile flow by a central mechanism. [D-Ala2]-Met-Enkephalinamide has analgesic properties .

HY-P3632

[DAla2, DArg6] Dynorphin A, (1-13) (porcine) DADAD	Opioid Receptor	Neurological Disease Metabolic Disease
[DAla2, DArg6] Dynorphin A, (1-13) (porcine) (DADAD) is an *opioid peptide* (dynorphinl-13, DYN) derivative found in porcine pituitary extracts. DYN is highly potent at the peripheral opioid receptors GPI and MVD, but is readily and rapidly degraded in vivo. [DAla2, DArg6] Dynorphin A, (1-13) (porcine) has some resistance to enzymatic cleavage and prevents peptide cleavage by enzymes .

HY-P1481

β-Casomorphin, human Human β-casomorphin 7	Opioid Receptor	Metabolic Disease
is an opioid peptide, acts as an agonist of opioid receptor .

HY-P1866

β-Endorphin, equine	Opioid Receptor	Neurological Disease
β-Endorphin, equine is an endogenous opioid peptide, which binds at high affinity to both *μ/δ opioid* receptors** . Analgesic properties .

HY-P3223A

Biphalin acetate	Opioid Receptor	Neurological Disease
Biphalin acetate, a BBB-penetrable opioid peptide analog, contains two active enkephalin pharmacophores.Biphalin acetate has high affinity for opioid receptors. Biphalin acetate shows analgesic effect in acute, neuropathic, and chronic animal pain models. Biphalin acetate is also an antiviral, antiproliferative, anti-inflammatory, and neuroprotective agent .

HY-W019787

BAM-12P	Opioid Receptor CXCR	Neurological Disease
BAM-12P, an endogenous opioid peptide, is a novel pro-Met-enkephalin. BAM-12P can activate *human κ-opioid* receptor (hKOR) with an EC₅₀ of 101 nM and a pEC₅₀ of 6.99. BAM-12P is a ligand for CXCR7 with an EC₅₀** of 175 nM .

HY-P11642A

Sialorphin TFA	Enteropeptidase Aminopeptidase Opioid Receptor ERK mTOR Androgen Receptor	Inflammation/Immunology
Sialorphin TFA is a neutral endopeptidase (NEP) and aminopeptidase N (APN) inhibitor that responds to androgen signals. Sialorphin TFA blocks the degradation of endogenous opioid peptides and interacts with μ-, δ-, κ-opioid receptors. Sialorphin TFA regulates the ERK/mTOR signaling pathway by inducing cell cycle arrest, enhancing ERK1/2 activity, and reducing the phosphorylation levels of mTOR, 4E-BP1, p70S6K; accordingly, Sialorphin TFA exhibits antiproliferative activity against colorectal cancer, glioma and prostate cancer cells without cytotoxicity. In addition, Sialorphin TFA also produces antinociceptive responses, regulates sexual behavior, relaxes corpus cavernosum smooth muscle, and alleviates experimental colitis. Sialorphin TFA is also a copper (II) ion-binding ligand. Sialorphin TFA has been used in mechanistic studies related to cancer, pain management and inflammatory bowel disease .

HY-P1331

BAM-22P Bovine adrenal medulla-22P	Opioid Receptor	Neurological Disease
BAM-22P, a highly potent opioid peptide, is a potent *opioid* agonist.

HY-P5061

Dynorphin A (1-13) amide	Opioid Receptor	Neurological Disease
Dynorphin A (1-13) amide is an endogenous opioid peptide that antagonizes morphine-induced analgesia .

HY-P1819

N-Acetyl-α-Endorphin	Opioid Receptor	Neurological Disease
N-Acetyl-α-Endorphin is an acetylated α-Endorphin at N-terminal. α-Endorphin is an endogenous opioid peptide.

HY-P3045

Bilaid B	Opioid Receptor	Others
Bilaid B (compound 2a) is a tetrapeptide. Bilaid B resembles opioid peptides albeit with a unique, alternating LDLD amino acid configuration. .

HY-P3555A

D-Ala-Gly-Phe-Met-NH2 monoacetate	Opioid Receptor	Others
D-Ala-Gly-Phe-Met-NH2 monoacetate, an opioid peptide, is a potent opiate δ-receptor agonist .

HY-P1863

α-Neoendorphin (1-8)	Opioid Receptor	Neurological Disease
α-Neoendorphin (1-8) is a 8-amino acid peptide derived from the N-terminal of α-Neoendorphin. α-Neoendorphin is an endogenous opioid peptide.

HY-176505

NOP antagonist 1	Opioid Receptor	Neurological Disease
NOP antagonist 1 (Compound (-)-31) is a *nociceptin opioid peptide* (NOP) antagonist with a K_b** of 8.65  nM. NOP antagonist 1 can be used for neuropsychiatric disorders research .

HY-P0179A

β-Casomorphin, bovine TFA β-Casomorphin-7 (bovine) TFA; Bovine β-casomorphin-7 TFA	Opioid Receptor	Neurological Disease Metabolic Disease
β-Casomorphin, bovine TFA (β-Casomorphin-7 (bovine) TFA) is a *opioid* peptide with an IC₅₀ of 14 μM in an Opioid receptors binding assay .

HY-P3625

Dynorphin (2-17), amide (porcine)	Endogenous Metabolite Opioid Receptor	Neurological Disease
Dynorphin (2-17), amide (porcine) is a dynorphin derivative with some analgesic effects. Dynorphin is a class of opioid peptides produced by the precursor protein dynorphinogen and is involved in pain, addiction and mood regulation .

HY-P0318

Hemorphin-7	Opioid Receptor Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Hemorphin-7 is a hemorphin peptide, an endogenous opioid peptide derived from the β-chain of hemoglobin. Hemorphin peptides exhibits antinociceptive and antihypertensive activities, activating opioid receptors and inhibiting angiotensin-converting enzyme (ACE).

HY-P10176

Acetalin-2	Opioid Receptor	Others
Acetalin-2 is an opioid peptide with a sequence of Ac-Arg-Phe-Met-Trp-Met-Arg-NH2. Acetalin-2 is selectively bound to [ ³H]DAMGO with a K ⁱ value of 93.3 nM .

HY-P3513A

β-Neo-Endorphin acetate	ERK MMP	Neurological Disease
β-Neo-Endorphin acetate is an endogenous opioid peptide. β-Neo-Endorphin acetate is a hypothalamic "big" Leu-enkephalin of porcine origin. β-Neo-Endorphin acetate shows activation of the Erk1/2, MMP-2 and MMP-9 .

HY-P3223

Biphalin TFA	Opioid Receptor	Neurological Disease
Biphalin TFA, a BBB-penetrable opioid peptide analog, contains two active enkephalin pharmacophores. Biphalin TFA has high affinity for opioid receptors. Biphalin TFA shows analgesic effect in acute, neuropathic, and chronic animal pain models. Biphalin TFA is also an antiviral, antiproliferative, anti-inflammatory, and neuroprotective agent .

HY-P1333A

Dynorphin A TFA	Opioid Receptor Apoptosis Caspase Endogenous Metabolite	Neurological Disease
Dynorphin A TFA is an endogenous opioid peptide involved in inhibitory neurotransmission in the central nervous system (CNS). Dynorphin A TFA is a highy potent *kappa opioid* receptor (KOR)** agonist, and is also an agonist for other opioid receptors, such as mu (MOR) and delta (DOR). Dynorphin A TFA can induce neuronal death, and can be used in the research of neurological disease .

HY-P1625

Daeatal Dynorphin A ethylamide (1-9)	Opioid Receptor	Neurological Disease
Daeatal (Dynorphin A ethylamide (1-9)) is an ethylamine-modified dynorphin fragment that can be used in the study of analgesia, addiction, depression, etc. Dynorphin A is an endogenous opioid peptide involved in inhibitory neurotransmission in the central nervous system (CNS). Dynorphin A is a highy potent *kappa opioid* receptor (KOR)** agonist, and is also an agonist for other opioid receptors, such as mu (MOR) and delta (DOR). Dynorphin A can induce neuronal death, and can be used in the research of neurological disease .

HY-138232

Lys-psi(CH2NH)-Trp(Nps)-OMe LTNAM	Aminopeptidase	Neurological Disease
Lys-psi(CH2NH)-Trp(Nps)-OMe is a lysine-tryptophan (Nps) pseudodipeptide analog. It is obtained by replacing the peptide bond in the Lys-Trp(Nps) molecule with an aminomethylene bond and has analgesic activity. Lys-psi(CH2NH)-Trp(Nps)-OMe induces a dose-dependent and naloxone-reversible analgesia after intracerebroventricular administration in mice, and its analgesic effect lasts longer than that of the original compound. It protects methionine enkephalin from degradation in rat striatal slices and binds to low-dose opioid peptides to produce analgesia. Lys-psi(CH2NH)-Trp(Nps)-OMe effectively inhibits brain aminopeptidase activity both in vitro and in vivo. The enhanced resistance of this pseudodipeptide to proteolysis may explain its prolonged analgesic activity.

HY-W099633

2-Aminodecanoic acid	Amino Acid Derivatives	Neurological Disease
2-Aminodecanoic acid is a lipophilic α-amino acid with an aliphatic side chain of 10 carbon atoms. 2-Aminodecanoic acid modifies the N-terminus of endogenous opioid peptide endomorphin-1 to enhance metabolic stability and membrane permeability. 2-Aminodecanoic acid can be used for the research of neuropathic pain .

HY-120925

TRV0109101	Opioid Receptor Arrestin	Neurological Disease
TRV0109101 is a *μ-opioid peptide* receptor (MOPR) selective agonist (K_D = 70 nM) with blood-brain barrier permeability. TRV0109101 selectively promotes G protein signaling pathway coupling while reducing the recruitment of β-arrestin*. TRV0109101 inhibits opioid*-induced mechanical hyperalgesia and induces antinociceptive tolerance. TRV0109101 is applicable for pain-related research .

HY-P11642

Sialorphin	ERK Androgen Receptor Opioid Receptor Enteropeptidase mTOR Aminopeptidase	Neurological Disease Inflammation/Immunology Cancer
Sialorphin is a neutral endopeptidase (NEP) and aminopeptidase N (APN) inhibitor that responds to androgen signals. Sialorphin blocks the degradation of endogenous opioid peptides and interacts with μ-, δ-, κ-opioid receptors. Sialorphin regulates the ERK/mTOR signaling pathway by inducing cell cycle arrest, enhancing ERK1/2 activity, and reducing the phosphorylation levels of mTOR, 4E-BP1, p70S6K; accordingly, Sialorphin exhibits antiproliferative activity against colorectal cancer, glioma and prostate cancer cells without cytotoxicity. In addition, Sialorphin also produces antinociceptive responses, regulates sexual behavior, relaxes corpus cavernosum smooth muscle, and alleviates experimental colitis. Sialorphin is also a copper (II) ion-binding ligand. Sialorphin has been used in mechanistic studies related to cancer, pain management and inflammatory bowel disease .

Cat. No.	Product Name	Target	Research Area

HY-P1333

Dynorphin A 1 Publications Verification	Opioid Receptor Apoptosis Caspase Endogenous Metabolite	Neurological Disease
Dynorphin A is an endogenous opioid peptide involved in inhibitory neurotransmission in the central nervous system (CNS). Dynorphin A is a highy potent *kappa opioid* receptor (KOR)** agonist, and is also an agonist for other opioid receptors, such as mu (MOR) and delta (DOR). Dynorphin A can induce neuronal death, and can be used in the research of neurological disease .

HY-P0179

β-Casomorphin, bovine β-Casomorphin-7 (bovine); Bovine β-casomorphin-7	Opioid Receptor	Neurological Disease Metabolic Disease
β-Casomorphin, bovine (β-Casomorphin-7 (bovine) ) is a *opioid* peptide with an IC₅₀ of 14 μM in an Opioid receptors binding assay .

HY-P1334

DPDPE 1 Publications Verification	Opioid Receptor	Neurological Disease
DPDPE, an opioid peptide, is a selective *δ-opioid* receptor?(DOR)** agonist?with anticonvulsant effects .

HY-W345510

Opiorphin	Neprilysin	Neurological Disease
Opiorphin, an opioid peptide, is a potent enkephalin-inactivating zinc ectopeptidases in human inhibitor. Opiorphin inhibits two enkephalin-catabolizing ectoenzymes, human neutral ecto-endopeptidase, hNEP (EC 3.4.24.11) with an IC₅₀ value of 11 μM, and human ecto-aminopeptidase, hAP-N (EC 3.4.11.2). Opiorphin displays potent analgesic activity by activating endogenous opioid-dependent transmission .

HY-P2159

Dynorphin A (1-8)	Opioid Receptor Endogenous Metabolite	Neurological Disease
Dynorphin A (1-8) is a ligand with preference for the *κ-opioid* receptor, and its IC₅₀** value against human placental κ-opioid receptor is 330 nM. Dynorphin A (1-8) mediates neuroprotective effects by inhibiting oxidative stress, suppressing apoptosis, and competitively displacing the binding of κ partial agonists. Dynorphin A (1-8) is the dominant opioid peptide in human placental villi and tissue extracts; it undergoes rapid hydrolysis and can enter the central nervous system via intranasal administration. Dynorphin A (1-8) can be used in studies related to ischemic stroke .

HY-P1596

Gluten Exorphin C	Opioid Receptor	Neurological Disease
Gluten exorphin C is an opioid peptide derived from wheat gluten. Its IC₅₀ values are 40 μM and 13.5 μM for μ opioid and δ opioid activities in the GPI and MVD assays, respectively.

HY-P3513

β-Neo-Endorphin	ERK MMP	Neurological Disease
β-Neo-Endorphin is an endogenous opioid peptide. β-Neo-Endorphin is a hypothalamic “big” Leu-enkephalin of porcine origin. β-Neo-Endorphin shows activation of the Erk1/2, MMP-2 and MMP-9 .

HY-P1334A

DPDPE TFA 1 Publications Verification	Opioid Receptor	Neurological Disease
DPDPE TFA, an opioid peptide, is a selective *δ-opioid* receptor (DOR)** agonist with anticonvulsant effects .

HY-P1742

Gluten Exorphin B5	Opioid Receptor	Metabolic Disease
Gluten Exorphin B5 is an exogenous opioid peptides derived from wheat gluten, acts on opioid receptor, increases postprandial plasma insulin level in rats .

HY-W000665

2,6-Dimethyl-L-tyrosine Dmt	Opioid Receptor	Neurological Disease
2,6-Dimethyl-L-tyrosine (Dmt) is a tyrosine derivative that enhances receptor affinity, functional bioactivity and in vivo analgesia of *opioid peptides* .

HY-P1481A

β-Casomorphin, human TFA Human β-casomorphin 7 TFA	Opioid Receptor	Neurological Disease Metabolic Disease
β-Casomorphin, human TFA (Human β-casomorphin 7 TFA) is an opioid peptide, acts as an agonist of opioid receptor .

HY-P2626

[D-Ala2]-Met-Enkephalin	Opioid Receptor	Neurological Disease
[D-Ala2]-Met-Enkephalin, an opioid peptide, is a potent *opioid* agonist. [D-Ala2]-Met-Enkephalin inhibits ACh-induced and suckling-induced oxytocin (OT) release .

HY-P1866A

β-Endorphin, equine TFA 1 Publications Verification	Opioid Receptor	Neurological Disease
β-Endorphin, equine TFA is an endogenous opioid peptide, which binds at high affinity to both *μ/δ opioid* receptors**. β-Endorphin, equine TFA has analgesic properties .

HY-P3550

β-Lipotropin (60-65) β-LPH (60-65); [Arg0] Met-Enkephalin	Opioid Receptor	Neurological Disease
β-Lipotropin (60-65) (β-LPH (60-65)), an opioid peptide, is a potent *opioid* agonist .

HY-P3555

D-Ala-Gly-Phe-Met-NH2	Opioid Receptor	Others
D-Ala-Gly-Phe-Met-NH2, an opioid peptide, is a potent opiate δ-receptor agonist .

HY-P3548

[D-Ala2]-Met-Enkephalinamide	Opioid Receptor	Neurological Disease
[D-Ala2]-Met-Enkephalinamide, an opioid peptide, is a potent *opioid* agonist. [D-Ala2]-Met-Enkephalinamide decreases bile flow by a central mechanism. [D-Ala2]-Met-Enkephalinamide has analgesic properties .

HY-P3632

[DAla2, DArg6] Dynorphin A, (1-13) (porcine) DADAD	Opioid Receptor	Neurological Disease Metabolic Disease
[DAla2, DArg6] Dynorphin A, (1-13) (porcine) (DADAD) is an *opioid peptide* (dynorphinl-13, DYN) derivative found in porcine pituitary extracts. DYN is highly potent at the peripheral opioid receptors GPI and MVD, but is readily and rapidly degraded in vivo. [DAla2, DArg6] Dynorphin A, (1-13) (porcine) has some resistance to enzymatic cleavage and prevents peptide cleavage by enzymes .

HY-P1481

β-Casomorphin, human Human β-casomorphin 7	Opioid Receptor	Metabolic Disease
is an opioid peptide, acts as an agonist of opioid receptor .

HY-P1866

β-Endorphin, equine	Opioid Receptor	Neurological Disease
β-Endorphin, equine is an endogenous opioid peptide, which binds at high affinity to both *μ/δ opioid* receptors** . Analgesic properties .

HY-P3223A

Biphalin acetate	Opioid Receptor	Neurological Disease
Biphalin acetate, a BBB-penetrable opioid peptide analog, contains two active enkephalin pharmacophores.Biphalin acetate has high affinity for opioid receptors. Biphalin acetate shows analgesic effect in acute, neuropathic, and chronic animal pain models. Biphalin acetate is also an antiviral, antiproliferative, anti-inflammatory, and neuroprotective agent .

HY-W019787

BAM-12P	Opioid Receptor CXCR	Neurological Disease
BAM-12P, an endogenous opioid peptide, is a novel pro-Met-enkephalin. BAM-12P can activate *human κ-opioid* receptor (hKOR) with an EC₅₀ of 101 nM and a pEC₅₀ of 6.99. BAM-12P is a ligand for CXCR7 with an EC₅₀** of 175 nM .

HY-P11642A

Sialorphin TFA	Enteropeptidase Aminopeptidase Opioid Receptor ERK mTOR Androgen Receptor	Inflammation/Immunology
Sialorphin TFA is a neutral endopeptidase (NEP) and aminopeptidase N (APN) inhibitor that responds to androgen signals. Sialorphin TFA blocks the degradation of endogenous opioid peptides and interacts with μ-, δ-, κ-opioid receptors. Sialorphin TFA regulates the ERK/mTOR signaling pathway by inducing cell cycle arrest, enhancing ERK1/2 activity, and reducing the phosphorylation levels of mTOR, 4E-BP1, p70S6K; accordingly, Sialorphin TFA exhibits antiproliferative activity against colorectal cancer, glioma and prostate cancer cells without cytotoxicity. In addition, Sialorphin TFA also produces antinociceptive responses, regulates sexual behavior, relaxes corpus cavernosum smooth muscle, and alleviates experimental colitis. Sialorphin TFA is also a copper (II) ion-binding ligand. Sialorphin TFA has been used in mechanistic studies related to cancer, pain management and inflammatory bowel disease .

HY-P1331

BAM-22P Bovine adrenal medulla-22P	Opioid Receptor	Neurological Disease
BAM-22P, a highly potent opioid peptide, is a potent *opioid* agonist.

HY-P5061

Dynorphin A (1-13) amide	Opioid Receptor	Neurological Disease
Dynorphin A (1-13) amide is an endogenous opioid peptide that antagonizes morphine-induced analgesia .

HY-P1819

N-Acetyl-α-Endorphin	Opioid Receptor	Neurological Disease
N-Acetyl-α-Endorphin is an acetylated α-Endorphin at N-terminal. α-Endorphin is an endogenous opioid peptide.

HY-P3045

Bilaid B	Opioid Receptor	Others
Bilaid B (compound 2a) is a tetrapeptide. Bilaid B resembles opioid peptides albeit with a unique, alternating LDLD amino acid configuration. .

HY-P3555A

D-Ala-Gly-Phe-Met-NH2 monoacetate	Opioid Receptor	Others
D-Ala-Gly-Phe-Met-NH2 monoacetate, an opioid peptide, is a potent opiate δ-receptor agonist .

HY-P1863

α-Neoendorphin (1-8)	Opioid Receptor	Neurological Disease
α-Neoendorphin (1-8) is a 8-amino acid peptide derived from the N-terminal of α-Neoendorphin. α-Neoendorphin is an endogenous opioid peptide.

HY-P0179A

β-Casomorphin, bovine TFA β-Casomorphin-7 (bovine) TFA; Bovine β-casomorphin-7 TFA	Opioid Receptor	Neurological Disease Metabolic Disease
β-Casomorphin, bovine TFA (β-Casomorphin-7 (bovine) TFA) is a *opioid* peptide with an IC₅₀ of 14 μM in an Opioid receptors binding assay .

HY-P3625

Dynorphin (2-17), amide (porcine)	Endogenous Metabolite Opioid Receptor	Neurological Disease
Dynorphin (2-17), amide (porcine) is a dynorphin derivative with some analgesic effects. Dynorphin is a class of opioid peptides produced by the precursor protein dynorphinogen and is involved in pain, addiction and mood regulation .

HY-P0318

Hemorphin-7	Opioid Receptor Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Hemorphin-7 is a hemorphin peptide, an endogenous opioid peptide derived from the β-chain of hemoglobin. Hemorphin peptides exhibits antinociceptive and antihypertensive activities, activating opioid receptors and inhibiting angiotensin-converting enzyme (ACE).

HY-P10176

Acetalin-2	Opioid Receptor	Others
Acetalin-2 is an opioid peptide with a sequence of Ac-Arg-Phe-Met-Trp-Met-Arg-NH2. Acetalin-2 is selectively bound to [ ³H]DAMGO with a K ⁱ value of 93.3 nM .

HY-P3223

Biphalin TFA	Opioid Receptor	Neurological Disease
Biphalin TFA, a BBB-penetrable opioid peptide analog, contains two active enkephalin pharmacophores. Biphalin TFA has high affinity for opioid receptors. Biphalin TFA shows analgesic effect in acute, neuropathic, and chronic animal pain models. Biphalin TFA is also an antiviral, antiproliferative, anti-inflammatory, and neuroprotective agent .

HY-P1333A

Dynorphin A TFA	Opioid Receptor Apoptosis Caspase Endogenous Metabolite	Neurological Disease
Dynorphin A TFA is an endogenous opioid peptide involved in inhibitory neurotransmission in the central nervous system (CNS). Dynorphin A TFA is a highy potent *kappa opioid* receptor (KOR)** agonist, and is also an agonist for other opioid receptors, such as mu (MOR) and delta (DOR). Dynorphin A TFA can induce neuronal death, and can be used in the research of neurological disease .

HY-P1625

Daeatal Dynorphin A ethylamide (1-9)	Opioid Receptor	Neurological Disease
Daeatal (Dynorphin A ethylamide (1-9)) is an ethylamine-modified dynorphin fragment that can be used in the study of analgesia, addiction, depression, etc. Dynorphin A is an endogenous opioid peptide involved in inhibitory neurotransmission in the central nervous system (CNS). Dynorphin A is a highy potent *kappa opioid* receptor (KOR)** agonist, and is also an agonist for other opioid receptors, such as mu (MOR) and delta (DOR). Dynorphin A can induce neuronal death, and can be used in the research of neurological disease .

HY-P11642

Sialorphin	ERK Androgen Receptor Opioid Receptor Enteropeptidase mTOR Aminopeptidase	Neurological Disease Inflammation/Immunology Cancer
Sialorphin is a neutral endopeptidase (NEP) and aminopeptidase N (APN) inhibitor that responds to androgen signals. Sialorphin blocks the degradation of endogenous opioid peptides and interacts with μ-, δ-, κ-opioid receptors. Sialorphin regulates the ERK/mTOR signaling pathway by inducing cell cycle arrest, enhancing ERK1/2 activity, and reducing the phosphorylation levels of mTOR, 4E-BP1, p70S6K; accordingly, Sialorphin exhibits antiproliferative activity against colorectal cancer, glioma and prostate cancer cells without cytotoxicity. In addition, Sialorphin also produces antinociceptive responses, regulates sexual behavior, relaxes corpus cavernosum smooth muscle, and alleviates experimental colitis. Sialorphin is also a copper (II) ion-binding ligand. Sialorphin has been used in mechanistic studies related to cancer, pain management and inflammatory bowel disease .

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MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
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opioid+peptide

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Peptides

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