1. GPCR/G Protein Neuronal Signaling Apoptosis Metabolic Enzyme/Protease
  2. Opioid Receptor Apoptosis Caspase Endogenous Metabolite
  3. Dynorphin A TFA

Dynorphin A TFA is an endogenous opioid peptide involved in inhibitory neurotransmission in the central nervous system (CNS). Dynorphin A TFA is a highy potent kappa opioid receptor (KOR) agonist, and is also an agonist for other opioid receptors, such as mu (MOR) and delta (DOR). Dynorphin A TFA can induce neuronal death, and can be used in the research of neurological disease.

For research use only. We do not sell to patients.

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Dynorphin A TFA Chemical Structure

Dynorphin A TFA Chemical Structure

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Description

Dynorphin A TFA is an endogenous opioid peptide involved in inhibitory neurotransmission in the central nervous system (CNS). Dynorphin A TFA is a highy potent kappa opioid receptor (KOR) agonist, and is also an agonist for other opioid receptors, such as mu (MOR) and delta (DOR). Dynorphin A TFA can induce neuronal death, and can be used in the research of neurological disease[1][2].

IC50 & Target[3]

Human Endogenous Metabolite

 

Caspase-3

 

κ Opioid Receptor/KOR

 

In Vitro

Dynorphin A TFA (10 μM, 4 h/72 h) increases caspase-3 activity and the level of cytochrome c released from mitochondria in mouse striatal neurons, and induces neuronal death[3].
dynorphin A TFA (33 μM, 4 h) elevates [Ca2+]i and causes a significant loss of neurons[4].
dynorphin A TFA (1 μM) inhibits the release of vasopressin (VP) from the isolated neural lobe[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[3]

Cell Line: Mouse striatal neurons
Concentration: 10 μM
Incubation Time: 0, 24, 48, 72 h
Result: Induced neuronal death (identified by the fragmentation and destruction of the cell body and neurites).
In Vivo

Dynorphin A TFA (intracerebroventricular injection, 1 μg of 2 μL, a single dose) inhibits vasopressin (VP) release in 24 h water-deprived male rats[5].
Dynorphin A TFA (intracerebroventricular injection, 500 pmol/5 μL per day for 4 d) alleviates stress-induced behavioral impairments in ddY mice accompanied by regulation of the 5-HTergic system in the brain[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 24 h water-deprived male rats[5]
Dosage: 1 μg of 2 μL
Administration: Intracerebroventricular injection
Result: Inhibited vasopressin (VP) release 30 min upon injection.
Animal Model: Male ddY mice[6]
Dosage: 15, 150, 1500 pmol/5 μL per day for 4 days
Administration: Intracerebroventricular injection
Result: Attenuated the repeated stress-induced escape failures from the shock.
Molecular Weight

2261.50

Formula

C101H156F3N31O25

Sequence

Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln

Sequence Shortening

YGGFLRRIRPKLKWDNQ

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Dynorphin A TFA
Cat. No.:
HY-P1333A
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