2-Aminodecanoic acid
2-Aminodecanoic acid is a lipophilic α-amino acid with an aliphatic side chain of 10 carbon atoms. 2-Aminodecanoic acid modifies the N-terminus of endogenous opioid peptide endomorphin-1 to enhance metabolic stability and membrane permeability. 2-Aminodecanoic acid can be used for the research of neuropathic pain.
For research use only. We do not sell to patients.
- CAS No.: 17702-88-4
- Formula: C10H21NO2
- Molecular Weight:187.28
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
2-Aminodecanoic acid (400 μM) does not inhibit purified recombinant human ADH3-mediated GSNO reduction[1].
2-Aminodecanoic acid-modified endomorphin-1 derivatives exhibit increased stability in Caco-2 cell homogenate[2].
2-Aminodecanoic acid-modified Dmt-endomorphin-1 exhibits increased stability in human plasma[2].
2-Aminodecanoic acid-modified endomorphin-1 derivatives exhibit increased permeability across Caco-2 cell monolayers[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 17702-88-4
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Molecular Weight 187.28
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Formula C10H21NO2
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SMILES
O=C(O)C(N)CCCCCCCC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Staab CA, et al. Medium-chain fatty acids and glutathione derivatives as inhibitors of S-nitrosoglutathione reduction mediated by alcohol dehydrogenase 3. Chem Biol Interact. 2009;180(1):113-118. [Content Brief]
[2]. Varamini P, et al. Lipo-endomorphin-1 derivatives with systemic activity against neuropathic pain without producing constipation. PLoS One. 2012;7(8):e41909. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
2-Aminodecanoic acid Related Classifications
HY-W099633 Related Classifications
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