1. GPCR/G Protein
    Neuronal Signaling
  2. Opioid Receptor
  3. β-Casomorphin, bovine

β-Casomorphin, bovine (Synonyms: β-Casomorphin-7 (bovine); Bovine β-casomorphin-7)

Cat. No.: HY-P0179
Handling Instructions

β-Casomorphin, bovine (β-Casomorphin-7 (bovine) ) is a opioid peptide with an IC50 of 14 μM in an Opioid receptors binding assay.

For research use only. We do not sell to patients.

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β-Casomorphin, bovine Chemical Structure

β-Casomorphin, bovine Chemical Structure

CAS No. : 72122-62-4

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Description

β-Casomorphin, bovine (β-Casomorphin-7 (bovine) ) is a opioid peptide with an IC50 of 14 μM in an Opioid receptors binding assay[1].

IC50 & Target

IC50: 14 μM (Opioid receptor)[1]

In Vitro

β-Casomorphin, bovine (0.1 μM; 30 minutes-24 hours) stimulates the secretion of mucin in DHE Cells after 8 h of treatment[2].
β-Casomorphin, bovine (0.1 μM; 24 hours) induces an increase in rMuc2 and rMuc3 mRNA levels[2].
β-Casomorphin, bovine do not modify the expression of rMuc1, rMuc4, and rMuc5AC[2].
β-Casomorphin, bovine (0.1 μM; 24 hours) stimulates MUC5AC expression and mucin Secretion in HT29-MTX Cells (human)[2].

In Vivo

β-Casomorphin, bovine (7.5×10−6 mol/day/kg ; i.g.; for 30 days) increases plasma insulin and decreased plasma glucagon of diabetic rats[3].
β-Casomorphin, bovine (7.5×10−6 mol/day/kg ; i.g.; for 30 days) alters the changes of SOD, GPx, T-AOC, MDA and H2O2 in the kidney of diabetic rats[3].
β-Casomorphin, bovine (7.5×10−6 mol/day/kg ; i.g.; for 30 days) reduces MDA (significantly) and H2O2 (non-significantly) level in the kidney compared to the diabetic rats[3].
β-Casomorphin, bovine (7.5×10−6 mol/day/kg ; i.g.; for 30 days) alleviates high glucose-induced decreasement in SOD and GPx activity, increasement in MDA contents in the NRK-52E cells[3].

Animal Model: Male Sprague-Dawley (SD) rats (200 g±10 g)[3]
Dosage: 7.5×10−6 mol/day/kg
Administration: Oral gavage; for 30 days
Result: Increased plasma insulin and decreased plasma glucagon of diabetic rats.
Molecular Weight

789.92

Formula

C₄₁H₅₅N₇O₉

CAS No.

72122-62-4

Sequence

Tyr-Pro-Phe-Pro-Gly-Pro-Ile

Sequence Shortening

YPFPGPI

Shipping

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

β-Casomorphin, bovineβ-Casomorphin-7 (bovine)Bovine β-casomorphin-7Opioid ReceptoropioidpeptidemucinInhibitorinhibitorinhibit

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