1. GPCR/G Protein
    Neuronal Signaling
  2. Opioid Receptor
  3. β-Casomorphin, bovine

β-Casomorphin, bovine (Synonyms: β-Casomorphin-7 (bovine); Bovine β-casomorphin-7)

Cat. No.: HY-P0179
Handling Instructions

β-casomorphin, bovine (β-casomorphin-7) is a opioid peptide with an IC50 of 14 μM in an Opioid receptors binding assay.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

β-Casomorphin, bovine Chemical Structure

β-Casomorphin, bovine Chemical Structure

CAS No. : 72122-62-4

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β-casomorphin, bovine (β-casomorphin-7) is a opioid peptide with an IC50 of 14 μM in an Opioid receptors binding assay.

IC50 & Target

IC50: 14 μM (Opioid receptor)[1]

In Vitro

β-casomorphin(β-casomorphin-7) strongly stimulates mucin secretion in the rat jejunum through a nervous pathway and opioid receptor activation. In rat DHE cells, β-casomorphin(β-casomorphin-7) increases the expression of rat mucin (rMuc)2 and rMuc3 but not rMuc1, rMuc4, and rMuc5AC. In human HT29-MTX cells, β-casomorphin(β-casomorphin-7) also increases MUC5AC mRNA levels (219% after 24 h of stimulation) and the secretion of this mucin. β-casomorphin(β-casomorphin-7) may contribute significantly to mucin production via a direct effect on intestinal goblet cells and the activation of -opioid receptors[2].

In Vivo

Oral administration of β-casomorphin(β-casomorphin-7) for 30 days to rats with STZ-induced diabetes results in a significant increase in serum level of insulin, and a decrease in the level of glucagon. The administration of β-casomorphin(β-casomorphin-7) alters the changes of SOD, GPx, T-AOC, MDA and H2O2 in the kidney of diabetic rats. β-casomorphin(β-casomorphin-7) alleviates high glucose-induced decreasement in SOD and GPx activity, increasement in MDA contents in the NRK-52E cells[3].

Molecular Weight








Sequence Shortening



Room temperature in continental US; may vary elsewhere.


Please store the product under the recommended conditions in the Certificate of Analysis.

Cell Assay

After 24 h of serum starvation, rat DHE cells are incubated without (control) or with β-casomorphin(β-casomorphin-7) (1-100 μM) for 30 min to 24 h. The amount of mucinlike glycoprotein in culture media is measured by enzymelinked lectin assay (ELLA) using biotinylated wheat germ agglutinin[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration


Diabetes is induced by intraperitoneal injection of STZ dissolved in 0.1 mol/L sodium citrate buffer (pH=4.0) at a dose of 60 mg/kg body weight. Fasting, tail-vein, blood glucose is measured three days after injection by using one touch glucomter, and Male Sprague-Dawley (SD) rats (200 g±10 g) that have a glucose level over 16.7 mM are considered to be diabetic rats. To investigate the preventive effects of β-casomorphin(β-casomorphin-7) treatment, β-casomorphin(β-casomorphin-7) treatment are carried out 2 weeks after the injection of STZ. All rats are euthanized after 30 days of treatment. On day 30, the animals are fasted overnight. Blood glucose, body and kidney weights are measured. Serum, plasma and kidney are collected for future analyses. All samples are stored at −70°C[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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