1. GPCR/G Protein
    Neuronal Signaling
  2. Opioid Receptor

β-Casomorphin, human (Synonyms: Human β-casomorphin 7)

Cat. No.: HY-P1481
Handling Instructions

β-Casomorphin, human is an opioid peptide, acts as an agonist of opioid receptor. Sequence: Tyr-Pro-Phe-Val-Glu-Pro-Ile;YPFVEPI.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

β-Casomorphin, human Chemical Structure

β-Casomorphin, human Chemical Structure

CAS No. : 102029-74-3

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25 mg USD 390 Get quote

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

β-Casomorphin, human is an opioid peptide, acts as an agonist of opioid receptor. Sequence: Tyr-Pro-Phe-Val-Glu-Pro-Ile;YPFVEPI.

IC50 & Target

Opioid receptor[2]

In Vitro

β-Casomorphin, human (TyrPro-Phe-Val-Glu-Pro-Ile) is also called human B-casein-(51-57), with the sequence equivalent to bovine B-casein-(60-66) (Tyr-ProPhe-Pro-G]y-Pro-Ile or B-casomorphin-7)[1]. β-Casomorphin, human (100 μM) increases the expression of rat mucin (rMuc)2 and rMuc3 but not rMuc1, rMuc4, and rMuc5AC in rat DHE cells, also elevates increased MUC5AC mRNA levels[2].

Solvent & Solubility
In Vitro: 

10 mM in H2O

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1574 mL 5.7870 mL 11.5741 mL
5 mM 0.2315 mL 1.1574 mL 2.3148 mL
10 mM 0.1157 mL 0.5787 mL 1.1574 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Cell Assay
[2]

To study the effect of β-Casomorphin, human and DAMGO, cells are seeded in 12-well culture plates. Experiments are performed 3 (DHE cells) or 21 days (HT29-MTX cells) after confluency. Twenty-four hours before the studies, the culture medium is replaced by serum-free medium to starve the cells from serum and to eliminate any interference from extraneous proteins or hormones. The experimental protocol is then the following: the serum-free medium is removed, and the monolayer cultures of DHE or HT29-MTX are washed twice with PBS (37°C). Serum-free medium with or without β-Casomorphin, human or DAMGO is added to the cells and incubated at 37°C for 30 min to 24 h in a humidified atmosphere. μ-Opioid receptor blockade is performed by preincubating the cells with cyprodime for 30 min before agonist addition. The supernatants are then collected, frozen, and stored at 20°C. Cells are processed with trypsin. The cell numbers per well are determined, and total RNA is isolated. All experiments are performed at least three times in triplicate[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

864.00

Formula

C₄₄H₆₁N₇O₁₁

CAS No.

102029-74-3

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
β-Casomorphin, human
Cat. No.:
HY-P1481
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β-Casomorphin, human

Cat. No.: HY-P1481