1. GPCR/G Protein
    Neuronal Signaling
  2. Opioid Receptor
  3. β-Casomorphin, human

β-Casomorphin, human (Synonyms: Human β-casomorphin 7)

Cat. No.: HY-P1481
Handling Instructions

is an opioid peptide, acts as an agonist of opioid receptor.

For research use only. We do not sell to patients.

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β-Casomorphin, human Chemical Structure

β-Casomorphin, human Chemical Structure

CAS No. : 102029-74-3

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is an opioid peptide, acts as an agonist of opioid receptor[1][2].

IC50 & Target

Opioid receptor[2]

In Vitro

β-Casomorphin, human TFA induces contractions of the guinea-pig ileum myenteric plexus/longitudinal muscle preparation with an IC50 of 29 μM[1].
β-Casomorphin, human TFA displaces 3H-spiperone from receptors in frontal cortex starting with 500 nM concentrations[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight








Sequence Shortening



Room temperature in continental US; may vary elsewhere.


Please store the product under the recommended conditions in the Certificate of Analysis.

Cell Assay

To study the effect of β-Casomorphin, human and DAMGO, cells are seeded in 12-well culture plates. Experiments are performed 3 (DHE cells) or 21 days (HT29-MTX cells) after confluency. Twenty-four hours before the studies, the culture medium is replaced by serum-free medium to starve the cells from serum and to eliminate any interference from extraneous proteins or hormones. The experimental protocol is then the following: the serum-free medium is removed, and the monolayer cultures of DHE or HT29-MTX are washed twice with PBS (37°C). Serum-free medium with or without β-Casomorphin, human or DAMGO is added to the cells and incubated at 37°C for 30 min to 24 h in a humidified atmosphere. μ-Opioid receptor blockade is performed by preincubating the cells with cyprodime for 30 min before agonist addition. The supernatants are then collected, frozen, and stored at 20°C. Cells are processed with trypsin. The cell numbers per well are determined, and total RNA is isolated. All experiments are performed at least three times in triplicate[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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β-Casomorphin, humanHuman β-casomorphin 7Opioid ReceptoropioidpeptideInhibitorinhibitorinhibit

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