1. GPCR/G Protein
    Neuronal Signaling
  2. Opioid Receptor

β-Casomorphin, human (Synonyms: Human β-casomorphin 7)

Cat. No.: HY-P1481
Handling Instructions

β-Casomorphin, human is an opioid peptide, acts as an agonist of opioid receptor.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

β-Casomorphin, human Chemical Structure

β-Casomorphin, human Chemical Structure

CAS No. : 102029-74-3

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References


β-Casomorphin, human is an opioid peptide, acts as an agonist of opioid receptor.

IC50 & Target

Opioid receptor[2]

In Vitro

β-Casomorphin, human (TyrPro-Phe-Val-Glu-Pro-Ile) is also called human B-casein-(51-57), with the sequence equivalent to bovine B-casein-(60-66) (Tyr-ProPhe-Pro-G]y-Pro-Ile or B-casomorphin-7)[1]. β-Casomorphin, human (100 μM) increases the expression of rat mucin (rMuc)2 and rMuc3 but not rMuc1, rMuc4, and rMuc5AC in rat DHE cells, also elevates increased MUC5AC mRNA levels[2].

Cell Assay

To study the effect of β-Casomorphin, human and DAMGO, cells are seeded in 12-well culture plates. Experiments are performed 3 (DHE cells) or 21 days (HT29-MTX cells) after confluency. Twenty-four hours before the studies, the culture medium is replaced by serum-free medium to starve the cells from serum and to eliminate any interference from extraneous proteins or hormones. The experimental protocol is then the following: the serum-free medium is removed, and the monolayer cultures of DHE or HT29-MTX are washed twice with PBS (37°C). Serum-free medium with or without β-Casomorphin, human or DAMGO is added to the cells and incubated at 37°C for 30 min to 24 h in a humidified atmosphere. μ-Opioid receptor blockade is performed by preincubating the cells with cyprodime for 30 min before agonist addition. The supernatants are then collected, frozen, and stored at 20°C. Cells are processed with trypsin. The cell numbers per well are determined, and total RNA is isolated. All experiments are performed at least three times in triplicate[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight








Sequence Shortening



Please store the product under the recommended conditions in the Certificate of Analysis.


Room temperature in continental US; may vary elsewhere

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Product Name:
β-Casomorphin, human
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β-Casomorphin, human

Cat. No.: HY-P1481