1. GPCR/G Protein
    Neuronal Signaling
  2. Opioid Receptor
  3. [Leu5]-Enkephalin, amide

[Leu5]-Enkephalin, amide (Synonyms: Leu-Enkephalin amide)

Cat. No.: HY-P1470
Handling Instructions

[Leu5]-Enkephalin, amide is a δ opioid receptor agonist.

For research use only. We do not sell to patients.

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[Leu5]-Enkephalin, amide Chemical Structure

[Leu5]-Enkephalin, amide Chemical Structure

CAS No. : 60117-24-0

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Description

[Leu5]-Enkephalin, amide is a δ opioid receptor agonist.

IC50 & Target

δ opioid receptor[1]

In Vitro

[Leu5]-Enkephalin causes concentration-dependent, reversible inhibition of pelvic nerve-evoked contractions, with an IC50 value of 2.1 nM[2].

In Vivo

Levels of [Leu5]-Enkephalin are significantly increased in the nucleus raphe magnus (NRM) of rats 2 weeks after the injection of complete Freund's adjuvant (CFA) (1.02±0.2 pmol/mg protein) as compared with saline-treated rats (0.49±0.04 pmol/mg protein; p<0.01). Tissue levels of [Leu5]-Enkephalin are uniformly increased in the caudal ventrolateral periaqueductal gray (PAG) 4 hr (1.15±0.25 pmol/mg protein), 4 d (1.16±0.18 pmol/mg protein), and 2 weeks (1.18±0.17 pmol/mg protein) after the injection of CFA as compared with saline-treated rats (0.55±0.03 pmol/mg protein; p<0.05, all times). A smaller increase in the levels of [Leu5]-Enkephalin occurred in the rostral aspect of the ventrolateral PAG at all time points. Finally, levels of [Leu5]-Enkephalin are also increased in the contralateral microcellular tegmental nucleus 4 d after the injection of CFA (0.53±0.04 pmol/mg protein) compared with levels in saline-treated rats (0.38±0.02 pmol/mg protein; p<0.05)[1].

Molecular Weight

554.64

Formula

C₂₈H₃₈N₆O₆

CAS No.

60117-24-0

Sequence

Tyr-Gly-Gly-Phe-Leu-NH2

Sequence Shortening

YGGFL-NH2

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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[Leu5]-Enkephalin, amide
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HY-P1470
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