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photosensitizer，ROS

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (6) Autophagy (1) Bacterial (1) BCRP (1) Biochemical Assay Reagents (1) Carboxylesterase (CES) (1) Caspase (1) CDK (1) Epigenetic Reader Domain (1) Fluorescent Dye (1) Fungal (1) HIF/HIF Prolyl-Hydroxylase (1) Necroptosis (1) Photosensitizer (8) PROTACs (1) Pyroptosis (1) Reactive Oxygen Species (ROS) (18)
By Research Areas:	Cancer (19) Cardiovascular Disease (1) Infection (3) Inflammation/Immunology (2) Metabolic Disease (1) Neurological Disease (1)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0305

5-Aminolevulinic acid hydrochloride 15+ Cited Publications 5-ALA hydrochloride; δ-Aminolevulinic acid hydrochloride; 5-Amino-4-oxopentanoic acid hydrochloride	Reactive Oxygen Species (ROS)	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
5-Aminolevulinic acid (5-ALA; δ-Aminolevulinic acid; 5-Amino-4-oxopentanoic acid) hydrochloride is an orally active heme precursor. 5-Aminolevulinic acid hydrochloride promotes aerobic energy metabolism and increases ATP levels by enhancing the activity of cytochrome c oxidase. 5-Aminolevulinic acid hydrochloride enhances LPS-induced proinflammatory cytokine production and gene activation, and restores the phagocytic activity and *ROS* generation capacity of neutrophils. 5-Aminolevulinic acid hydrochloride selectively accumulates protoporphyrin IX in tumor cells; as a photosensitizer and radiosensitizer, it induces ROS burst upon light or X-ray irradiation to inhibit tumor growth. 5-Aminolevulinic acid hydrochloride can be applied to the research of septic shock, melanoma, and cancer radiotherapy .

HY-W000450

5-Aminolevulinic acid 15+ Cited Publications 5-ALA; δ-Aminolevulinic acid; 5-Amino-4-oxopentanoic acid	Reactive Oxygen Species (ROS)	Cardiovascular Disease Cancer
5-Aminolevulinic acid (5-ALA; δ-Aminolevulinic acid; 5-Amino-4-oxopentanoic acid) is an orally active heme precursor. 5-Aminolevulinic acid promotes aerobic energy metabolism and increases ATP levels by enhancing the activity of cytochrome c oxidase. 5-Aminolevulinic acid enhances LPS-induced proinflammatory cytokine production and gene activation, and restores the phagocytic activity and *ROS* generation capacity of neutrophils. 5-Aminolevulinic acid selectively accumulates protoporphyrin IX in tumor cells; as a photosensitizer and radiosensitizer, it induces ROS burst upon light or X-ray irradiation to inhibit tumor growth. 5-Aminolevulinic acid can be applied to the research of septic shock, melanoma, and cancer radiotherapy .

HY-N10902

Methyl pheophorbide a	Photosensitizer Reactive Oxygen Species (ROS) Caspase Apoptosis	Cancer
Methyl pheophorbide a is a natural product, one of the chlorophyll-a derivatives. Methyl pheophorbide a is a photosensitizer that produces singlet oxygen and reactive oxygen species (ROS) under light of specific wavelength, thereby leading to cell death .

HY-175329

BTF-DNBS	Pyroptosis Reactive Oxygen Species (ROS)	Cancer
BTF-DNBS is a glutathione (GSH)-responsive small-molecule photosensitizer (PS). BTF-DNBS disrupts mitochondrial function and triggers Golgi-mediated pyroptosis, serving as a reactive oxygen species (ROS) generator. BTF-DNBS is promising for research of cancers .

HY-N16417

Elsinochrome C	Apoptosis Reactive Oxygen Species (ROS)	Infection Cancer
Elsinochrome C is a photosensitizer. Elsinochrome C relies on light activation to generate reactive oxygen species (ROS) such as singlet oxygen (1O2), inducing apoptosis or directly disrupting pathogen structures. Elsinochrome C is promising for research of skin cancers, HIV-associated infections, and refractory skin diseases .

HY-N10611

Elsinochrome A	Reactive Oxygen Species (ROS) Apoptosis Autophagy Fungal Fluorescent Dye	Infection Cancer
Elsinochrome A is a perylene quinone photosensitizer, and can generate reactive oxygen species (ROS) to induce apoptosis and autophagy under light excitation. Elsinochrome A also shows antifungal activity against C. albicans biofilm through photodynamic antimicrobial chemotherapy (PACT). Elsinochrome A can be used for research of photodynamic therapy (PDT) (Ex: 460 nm) .

HY-175591

Photosensitizer-7	Photosensitizer Apoptosis Reactive Oxygen Species (ROS)	Cancer
Photosensitizer-7 is a endoplasmic reticulum (ER)-targeted photosensitizer (PS) (λ_ab = 610 nm, λ_em = 622 nm). Photosensitizer-7shows an IC₅₀ of 4.006 μM in HeLa cells and 3.28 μM in MCF-7 cells under light irradiation. Photosensitizer-7 exhibits dose-dependent cellular uptake and predominant colocalization with ER. Photosensitizer-7 induces dose-dependent intracellular *ROS* generation, reduces mitochondrial membrane potential, and increases apoptosis upon light irradiation in cells. Photosensitizer-7 significantly inhibits tumor growth in MCF-7 tumor-bearing mice. Photosensitizer-7 can be used for the study of photodynamic anticancer applications .

HY-151940

Mal-Pc	Reactive Oxygen Species (ROS)	Cancer
Mal-Pc is a versatile molecular photosensitizer designed based phthalocyanine and maleimides. Mal-Pc can react with GSH to deplete GSH and reduce aggregation, thereby improving *ROS* (Reactive Oxygen Species)-mediated effect of photodynamic therapy (PDT) in cancer cells .

HY-156092

*Antitumor photosensitizer-4*	BCRP Apoptosis	Cancer
Antitumor photosensitizer-4 (compound 10b) is a potent tyrosine kinase inhibitor (TKI) targeting ABCG2. Antitumor photosensitizer-4 is a photosensitizer (PS) consisting of a conjugate of dasatinib (HY-10181) and imatinib (HY-15463). Antitumor photosensitizer-4 induces apoptosis and ROS production and exhibits strong phototoxicity to HepG2 and B16-F10 cells .

HY-175214

*Antitumor photosensitizer-9*	Reactive Oxygen Species (ROS) Photosensitizer	Cancer
Antitumor photosensitizer-9 is a near-infrared *Photosensitizer* (PS) with a high singlet oxygen production rate (relative rate = 1.79). Antitumor photosensitizer-9 exhibits strong phototoxicity against various cancer cells and induces *ROS* generation under light irradiation. Antitumor photosensitizer-9 inhibits tumor growth in vivo and exhibits excellent anticancer photodynamic therapy (PDT) efficacy at low drug and light doses. Antitumor photosensitizer-9 can be used in photodynamic therapy research .

HY-159005

TDTM	Biochemical Assay Reagents	Others
TDTM is a photosensitizer, that promotes the generation of *ROS* with induction of the light. TDTM can be used for synthesis of Janus liposozyme .

HY-176725

ZnPcPs	Photosensitizer Reactive Oxygen Species (ROS)	Cancer
ZnPcPs is a *photosensitizer* that generates *ROS. ZnPcPs can be used to synthesize the photo*-activated BRD4 degrader pZnPc-O3-JQ1 (HY-176724) .

HY-168854

TBC-1	Photosensitizer Reactive Oxygen Species (ROS)	Cancer
TBC-1 is a chlorophyll-a derivative, is a photosensitizer that can be used in photodynamic therapy (PDT). TBC-1 efficiently generats Type-I *ROS* and endoplasmic reticulum targeting ability. TBC-1 shows biocompatibility and PDT efficiency in vitro under both normoxia and hypoxia .

HY-147915

Benz-AP	Carboxylesterase (CES) Reactive Oxygen Species (ROS)	Cancer
Benz-AP is a potent *photosensitizer. Benz-AP produces singlet oxygen, with a negative correlation with hCES2 (Human carboxylesterase 2) activity. Benz-AP displays a higher photocytotoxicity potency in cancer cells under low hCES2 environments. Upon TPE (Two-photon excitation), Benz-AP produces ROS* and kills cancer cells and tumor spheroids .

HY-176724

ZnPc-O3-JQ1	Epigenetic Reader Domain Reactive Oxygen Species (ROS) HIF/HIF Prolyl-Hydroxylase	Cancer
ZnPc-O3-JQ1 is a light-triggered BRD4 degrader. Under illumination, ZnPc-O3-JQ1 generates reactive oxygen species (ROS) that degrades BRD4. The degradation of BRD4 results in downregulation of HIF-1α, thereby counteracting the photodynamic therapy (PDT) resistance induced by tumor hypoxia. ZnPc-O3-JQ1 exhibits both Type I and Type II PDT mechanisms. The structure of ZnPc-O3-JQ1 consists of three parts: BRD4 ligand (HY-78695); Linker (HY-W040165); Photosensitizer (HY-176725) .

HY-183797

Antitumor agent-218	Photosensitizer Reactive Oxygen Species (ROS) Necroptosis	Cancer
Antitumor agent-218 is an aggregation-induced emission (AIE)-based photosensitizer. Antitumor agent-218 selectively accumulates in the endoplasmic reticulum, and generates *ROS* within the endoplasmic reticulum upon irradiation to induce necroptosis of tumor cells. Antitumor agent-218 can be used in cancer-related research .

HY-183570

*Antitumor photosensitizer-11*	Photosensitizer Reactive Oxygen Species (ROS)	Cancer
Antitumor photosensitizer-11 is a type-I carbazole/benzindolium photosensitizer with antitumor activity. Antitumor photosensitizer-11 induces *ROS* generation via a type-I pathway, forming superoxide anions and hydroxyl radicals. Antitumor photosensitizer-11 triggers immunogenic cell death in cancer cells via enhanced oxidative stress. Antitumor photosensitizer-11 exhibits antiproliferative activity in normoxic and hypoxic environments, inhibits breast cancer tumor growth in vivo, and promotes dendritic cell maturation and T cell infiltration. Antitumor photosensitizer-11 can be used for the research of cancer, such as breast cancer .

HY-W075248

m-THPP Tetra(3-hydroxyphenyl)porphyrin; 3-THPP	Photosensitizer Bacterial Reactive Oxygen Species (ROS)	Infection Cancer
m-THPP (Tetra(3-hydroxyphenyl)porphyrin; 3-THPP) is a photosensitizer. m-THPP can weakly induce *ROS* production and shows antitumor and antibacterial activity. m-THPP can be used for the research of photodynamic therapy (PDT) .

HY-181906

ZnPc-PEG2-VH032	PROTACs Reactive Oxygen Species (ROS) CDK	Cancer
ZnPc-PEG2-VH032 is a VHL-pathway-dependent photodegradation targeting chimera (PDTAC) and cytotoxic agent. ZnPc-PEG2-VH032 (HY-120217) binds to the VHL ligand domain, and then specifically degrades VHL under light irradiation, a process independent of non-specific *ROS*-mediated protein damage. ZnPc-PEG2-VH032 uses Zinc phthalocyanine (HY-19204) as a photosensitizer, and generates *ROS* via type I and type II photodynamic pathways under 680 nm LED irradiation. On one hand, it targets and degrades the bound VHL protein through *ROS; on the other hand, it exerts direct photodynamic cytotoxicity. Meanwhile, the degradation of VHL downregulates the phosphorylation level of CDK2/4, induces cell cycle arrest in tumor cells, further enhances the sensitivity of tumor cells to oxidative damage caused by ROS, and achieves a synergistic anti-tumor effect. ZnPc-PEG2-VH032 exerts significant in vivo efficacy in an orthotopic mouse model of non-muscle invasive bladder cancer (NMIBC*) .

HY-180825

Anticancer agent 292	Apoptosis Reactive Oxygen Species (ROS)	Inflammation/Immunology Cancer
Anticancer agent 292 (Compound P4) is a photosensitizer for anti-melanoma. Anticancer agent 292 shows good biocompatibility under dark conditions and, upon illumination, induces apoptosis and partial necrosis in B16-F10 cells by disrupting the lysosomal membrane. Anticancer agent 292 not only directly kills tumor cells through the generation of reactive oxygen species (ROS), but also induces immune-prone cell death (ICD), thereby generating anti-tumor immune effects. Anticancer agent 292 can be used in the research of photodynamic therapy for melanoma .

5-Aminolevulinic acid hydrochloride 15+ Cited Publications 5-ALA hydrochloride; δ-Aminolevulinic acid hydrochloride; 5-Amino-4-oxopentanoic acid hydrochloride	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Cancer	Reactive Oxygen Species (ROS)
5-Aminolevulinic acid (5-ALA; δ-Aminolevulinic acid; 5-Amino-4-oxopentanoic acid) hydrochloride is an orally active heme precursor. 5-Aminolevulinic acid hydrochloride promotes aerobic energy metabolism and increases ATP levels by enhancing the activity of cytochrome c oxidase. 5-Aminolevulinic acid hydrochloride enhances LPS-induced proinflammatory cytokine production and gene activation, and restores the phagocytic activity and *ROS* generation capacity of neutrophils. 5-Aminolevulinic acid hydrochloride selectively accumulates protoporphyrin IX in tumor cells; as a photosensitizer and radiosensitizer, it induces ROS burst upon light or X-ray irradiation to inhibit tumor growth. 5-Aminolevulinic acid hydrochloride can be applied to the research of septic shock, melanoma, and cancer radiotherapy .

5-Aminolevulinic acid 15+ Cited Publications 5-ALA; δ-Aminolevulinic acid; 5-Amino-4-oxopentanoic acid	Cardiovascular Disease Structural Classification Classification of Application Fields Amino acids Endogenous metabolite Human Gut Microbiota Metabolites Immune System Disorder Microorganisms Ketones, Aldehydes, Acids Disease markers Disease Research Fields Source Classification Cancer	Reactive Oxygen Species (ROS)
5-Aminolevulinic acid (5-ALA; δ-Aminolevulinic acid; 5-Amino-4-oxopentanoic acid) is an orally active heme precursor. 5-Aminolevulinic acid promotes aerobic energy metabolism and increases ATP levels by enhancing the activity of cytochrome c oxidase. 5-Aminolevulinic acid enhances LPS-induced proinflammatory cytokine production and gene activation, and restores the phagocytic activity and *ROS* generation capacity of neutrophils. 5-Aminolevulinic acid selectively accumulates protoporphyrin IX in tumor cells; as a photosensitizer and radiosensitizer, it induces ROS burst upon light or X-ray irradiation to inhibit tumor growth. 5-Aminolevulinic acid can be applied to the research of septic shock, melanoma, and cancer radiotherapy .

Methyl pheophorbide a	Alkaloids Pyrrole Alkaloids Pterocarpus soyauxii Taub. Plants Compositae Source Classification	Photosensitizer Reactive Oxygen Species (ROS) Caspase Apoptosis
Methyl pheophorbide a is a natural product, one of the chlorophyll-a derivatives. Methyl pheophorbide a is a photosensitizer that produces singlet oxygen and reactive oxygen species (ROS) under light of specific wavelength, thereby leading to cell death .

Elsinochrome C	Quinones Structural Classification Microorganisms Source Classification	Apoptosis Reactive Oxygen Species (ROS)
Elsinochrome C is a photosensitizer. Elsinochrome C relies on light activation to generate reactive oxygen species (ROS) such as singlet oxygen (1O2), inducing apoptosis or directly disrupting pathogen structures. Elsinochrome C is promising for research of skin cancers, HIV-associated infections, and refractory skin diseases .

Elsinochrome A	Quinones Structural Classification Microorganisms Source Classification	Reactive Oxygen Species (ROS) Apoptosis Autophagy Fungal Fluorescent Dye
Elsinochrome A is a perylene quinone photosensitizer, and can generate reactive oxygen species (ROS) to induce apoptosis and autophagy under light excitation. Elsinochrome A also shows antifungal activity against C. albicans biofilm through photodynamic antimicrobial chemotherapy (PACT). Elsinochrome A can be used for research of photodynamic therapy (PDT) (Ex: 460 nm) .

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photosensitizer，ROS

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