Photosensitizer-7
Photosensitizer-7 is a endoplasmic reticulum (ER)-targeted photosensitizer (PS) (λab = 610 nm, λem = 622 nm). Photosensitizer-7shows an IC50 of 4.006 μM in HeLa cells and 3.28 μM in MCF-7 cells under light irradiation. Photosensitizer-7 exhibits dose-dependent cellular uptake and predominant colocalization with ER. Photosensitizer-7 induces dose-dependent intracellular ROS generation, reduces mitochondrial membrane potential, and increases apoptosis upon light irradiation in cells. Photosensitizer-7 significantly inhibits tumor growth in MCF-7 tumor-bearing mice. Photosensitizer-7 can be used for the study of photodynamic anticancer applications.
For research use only. We do not sell to patients.
- Formula: C43H37BF4N2O2
- Molecular Weight:700.57
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Photosensitizer-7 (Compound 4j) exhibits an absorption maximum at 610 nm with a molar extinction coefficient of 53,000 M-1cm-1, a fluorescence emission maximum at 622 nm, a fluorescence quantum yield of 0.38, and a singlet oxygen quantum yield of 0.44[1].
Photosensitizer-7 (24 h) shows an IC50 of 4.006 μM in HeLa cells and 3.28 μM in MCF-7 cells under light irradiation, while its IC50 under dark conditions is 19.93 μM in HeLa cells and 135.9 μM in MCF-7 cells[1].
Photosensitizer-7 (2-8 μM, 24 h) induces negligible intracellular ROS production in MCF-7 cells under dark conditions, while under light irradiation, it triggers a significant dose-dependent increase in ROS levels[1].
Photosensitizer-7 (2-8 μM, 24 h) causes a dose-dependent reduction in mitochondrial membrane potential (ΔΨm) and increases the apoptosis rate of MCF-7 cells under light excitation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7 cells
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Concentration:2, 4, 8 μM
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Incubation Time:24 h
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Result:Increased the apoptosis rate of MCF-7 cells under light excitation.
Photosensitizer-7 (20-40 mg/kg, intratumoral injection, once) significantly inhibits tumor growth in MCF-7 tumor-bearing female BALB/c nude mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:MCF-7 cells (1 × 107 cells/mouse in appropriate volume of normal saline) were subcutaneously implanted into the right flanks of 5-week-old female BALB/c nude mice[1]
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Dosage:20 mg/kg, 40 mg/kg
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Administration:Intratumoral injection followed by 30 J/cm2 light irradiation 1 h later at once
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Result:Inhibited tumor growth.
Showed no significant changes in body weight.
Reduced tumor cell nuclear density and caused significant deformation of tumor cell nuclei in MCF-7 tumor tissues.
Chemical Information
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Molecular Weight 700.57
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Formula C43H37BF4N2O2
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SMILES
FB1(F)[N]2=C(c3c(C)cc(OCC)cc3C)C(C=CC=C4)=C4C2=C(c5cc(F)c(F)cc5)C6=C7C=CC=CC7=C(c8c(C)cc(OCC)cc8C)N16
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Photosensitizer-7 Related Classifications
HY-175591 Related Classifications
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