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Art. -Nr.: HY-147915

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Benz-AP

Benz-AP is a potent photosensitizer. Benz-AP produces singlet oxygen, with a negative correlation with hCES2 (Human carboxylesterase 2) activity. Benz-AP displays a higher photocytotoxicity potency in cancer cells under low hCES2 environments. Upon TPE (Two-photon excitation), Benz-AP produces ROS and kills cancer cells and tumor spheroids.

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CAS. Nr.: 2416220-53-4
Formel: C₂₀H₁₃NO₂
Molecular Weight:299.32

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Benz-AP Chemical Structure

CAS. Nr.: 2416220-53-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Carboxylesterase (CES) Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	CC₅₀	>32 μM Compound: Benz-AP	Dark toxicity against human A549 cells assessed as reduction in cell viability after 3 hrs by MTT assay Dark toxicity against human A549 cells assessed as reduction in cell viability after 3 hrs by MTT assay	[PMID: 35700557]
A549	CC₅₀	4.4 μM Compound: Benz-AP	Phototoxicity against human A549 cells assessed as reduction in cell viability after 3 hrs followed by compound washout and 415 nm light irradiation measured after overnight incubation by MTT assay Phototoxicity against human A549 cells assessed as reduction in cell viability after 3 hrs followed by compound washout and 415 nm light irradiation measured after overnight incubation by MTT assay	[PMID: 35700557]
HepG2	CC₅₀	>32 μM Compound: Benz-AP	Dark toxicity against human HepG2 cells assessed as reduction in cell viability after 3 hrs by MTT assay Dark toxicity against human HepG2 cells assessed as reduction in cell viability after 3 hrs by MTT assay	[PMID: 35700557]
HepG2	CC₅₀	>32 μM Compound: Benz-AP	Phototoxicity against human HepG2 cells assessed as reduction in cell viability after 3 hrs followed by compound washout and 415 nm light irradiation measured after overnight incubation by MTT assay Phototoxicity against human HepG2 cells assessed as reduction in cell viability after 3 hrs followed by compound washout and 415 nm light irradiation measured after overnight incubation by MTT assay	[PMID: 35700557]
MCF7	CC₅₀	>32 μM Compound: Benz-AP	Dark toxicity against human MCF7 cells assessed as reduction in cell viability after 3 hrs by MTT assay Dark toxicity against human MCF7 cells assessed as reduction in cell viability after 3 hrs by MTT assay	[PMID: 35700557]
MCF7	CC₅₀	1.6 μM Compound: Benz-AP	Phototoxicity against human MCF7 cells assessed as reduction in cell viability after 3 hrs followed by compound washout and 415 nm light irradiation measured after overnight incubation by MTT assay Phototoxicity against human MCF7 cells assessed as reduction in cell viability after 3 hrs followed by compound washout and 415 nm light irradiation measured after overnight incubation by MTT assay	[PMID: 35700557]
PANC-1	CC₅₀	>32 μM Compound: Benz-AP	Dark toxicity against human PANC-1 cells assessed as reduction in cell viability after 3 hrs by MTT assay Dark toxicity against human PANC-1 cells assessed as reduction in cell viability after 3 hrs by MTT assay	[PMID: 35700557]
PANC-1	CC₅₀	0.647 μM Compound: Benz-AP	Induction of cell death in human PANC-1 cells assessed as reduction in cell viability preincubated for 2 hrs followed by compound washout and immediate 900 nm light irradiation and measured 1 hr post light irradiation by two-photon based ReadyProbes blue/ Induction of cell death in human PANC-1 cells assessed as reduction in cell viability preincubated for 2 hrs followed by compound washout and immediate 900 nm light irradiation and measured 1 hr post light irradiation by two-photon based ReadyProbes blue/	[PMID: 35700557]
PANC-1	CC₅₀	0.647 μM Compound: Benz-AP	Induction of cell death in human PANC-1 cells assessed as reduction in cell viability preincubated for 3 hrs followed by compound washout and immediate 900 nm light irradiation and measured 1 hr post light irradiation by two-photon based MTT assay Induction of cell death in human PANC-1 cells assessed as reduction in cell viability preincubated for 3 hrs followed by compound washout and immediate 900 nm light irradiation and measured 1 hr post light irradiation by two-photon based MTT assay	[PMID: 35700557]
PANC-1	CC₅₀	1.4 μM Compound: Benz-AP	Phototoxicity against human PANC-1 cells assessed as reduction in cell viability after 3 hrs followed by compound washout and 415 nm light irradiation measured after overnight incubation by MTT assay Phototoxicity against human PANC-1 cells assessed as reduction in cell viability after 3 hrs followed by compound washout and 415 nm light irradiation measured after overnight incubation by MTT assay	[PMID: 35700557]

Chemical Information

CAS. Nr. 2416220-53-4
Molecular Weight 299.32
Formel C₂₀H₁₃NO₂
SMILES

O=C(NC1=C2C=CC=C3C(C=CC(C=C1)=C32)=O)C4=CC=CC=C4
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Kailass K, et al. Two-Photon Photodynamic Therapy Targeting Cancers with Low Carboxylesterase 2 Activity Guided by Ratiometric Fluorescence. J Med Chem. 2022 Jun 14. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biologische Aktivität
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Chemical Information
Reinheit & Dokumentation
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Benz-AP

Alle Carboxylesterase (CES) Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Benz-AP Related Classifications

HY-147915 Related Classifications