Antitumor photosensitizer-9
Antitumor photosensitizer-9 is a near-infrared Photosensitizer (PS) with a high singlet oxygen production rate (relative rate = 1.79). Antitumor photosensitizer-9 exhibits strong phototoxicity against various cancer cells and induces ROS generation under light irradiation. Antitumor photosensitizer-9 inhibits tumor growth in vivo and exhibits excellent anticancer photodynamic therapy (PDT) efficacy at low drug and light doses. Antitumor photosensitizer-9 can be used in photodynamic therapy research.
For research use only. We do not sell to patients.
- Formula: C44H41BIN5O2
- Molecular Weight:809.54
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Antitumor photosensitizer-9 (Compound A1) (2 h) shows Light dose-related photo-toxicity against HeLa cells, with IC50s < 5.0 nM[1].
Antitumor photosensitizer-9 (2 h) shows phototoxicity (IC50s = 3.7, 3.6, 4.5, 3.7 nM) and dark cytotoxicity (IC50s = 11.5, 13.5, 12.7, 10.7 μM) in HeLa, HepG 2, B16–F10, HUVEC cells[1].
Antitumor photosensitizer-9 (5 μM, 2 h) reaches peak intracellular accumulation and mainly accumulates in the ER in HeLa cells[1].
Antitumor photosensitizer-9 (0-500 nM,2 h) induces the production of ROS under light irradiation in HeLa cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Female BALB/c Nude mice (6-8 weeks old, 20-22 g) bearing HeLa cells (5 × 106 cells, 0.1 mL, s.c.) [1]
-
Dosage:2 mg/kg
-
Administration:i.v., once, 24 days of PDT treatment
-
Result:Inhibited tumor growth, with tumor volume decreased by 78% and had no physiological toxicity, was more effective than photosensitizers Ce6 (HY-13594) and BDP4 (HY-D1452).
Chemical Information
-
Molecular Weight 809.54
-
Formula C44H41BIN5O2
-
SMILES
IC(C(C1=CC=C(C=C1)OC)=[N]2C3=NC4=C(C=C(N4B2(C#CCN(C)C)C#CCN(C)C)C5=CC=C(C=C5)OC)C6=CC=CC=C6)=C3C7=CC=CC=C7
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antitumor photosensitizer-9 Related Classifications
HY-175214 Related Classifications
Powered by Bioz