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saikosaponin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amyloid-β (1) Bacterial (4) Biochemical Assay Reagents (1) Drug Derivative (2) Estrogen Receptor/ERR (2) HCV (2) Hedgehog (1) Interleukin Related (1) LXR (2) MMP (1) NADPH Oxidase (1) NF-κB (2) P-glycoprotein (2) Reference Standards (5) Smo (2) STAT (3) TNF Receptor (1)
By Research Areas:	Cancer (8) Infection (6) Inflammation/Immunology (10) Metabolic Disease (5) Neurological Disease (2)

Inhibitors & Agonists

Natural
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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0250

Saikosaponin D Maximum Cited Publications 10 Publications Verification	STAT NF-κB Estrogen Receptor/ERR Bacterial	Infection Inflammation/Immunology Cancer
Saikosaponin D is a triterpene saponin isolated from Bupleurum, with anti-inflammatory, anti-bacterial, anti-tumor, and anti-allergic activities; Saikosaponin D inhibits selectin, STAT3 and NF-kB and activates estrogen receptor-β.

HY-N0246

Saikosaponin A 5 Publications Verification	LXR Bacterial	Inflammation/Immunology Cancer
Saikosaponin A is the main active ingredient in Bupleurum chinense, which can regulate lipid metabolism and promote cholesterol efflux in early atherosclerosis. In addition, Saikosaponin A may also serve as a potential peroxisome proliferator-activated receptor γ (PPAR-γ) agonist, significantly promoting the expression of PPAR-γ. Saikosaponin A can be used in the study of hyperlipidemic pancreatitis .

HY-N0247

Saikosaponin B1 2 Publications Verification	Hedgehog Smo STAT Interleukin Related TNF Receptor	Inflammation/Immunology Cancer
Saikosaponin B1 is a bioactive constituent of Radix Bupleuri. Saikosaponin B1 is an agonist of the 5-HT_2C receptor with an EC₅₀ of 147.41 μM. Saikosaponin B1 inhibits the Hedgehog (Hh) signaling pathway by targeting the transmembrane protein SMO. Sailosaponin B1 can reduce liver fibrosis. Saikosaponin B1 has anti-cancer activities thus can be studies in research for cancers such as Medulloblastoma (MB) .

HY-N0249

Saikosaponin C 2 Publications Verification	MMP	Infection Inflammation/Immunology
Saikosaponin C is an orally active MMP-2 inducer. Saikosaponin C induces the survival, growth, migration and capillary tube formation of endothelial cells. Saikosaponin C inhibits the early stage of hepatitis C virus infection. Saikosaponin C can be used in research related to ischemic tissue diseases, chronic kidney diseases and hepatitis C virus infection .

HY-N0248

Saikosaponin B2 2 Publications Verification	HCV P-glycoprotein	Infection Cancer
Saikosaponin B2 is an antiviral and anticancer agent that regulates multiple transporters (such as various solute carriers and ATP-binding cassette transporters including MRP1, MRP2, and OCT2). Saikosaponin B2 is isolated from the plant glycoside component of the roots of Bupleurum scorzonerifolium. Saikosaponin B2 enhances the liver targeting of anticancer drugs via vinegar-baked Radix Bupleuri. Saikosaponin B2 inhibits HCV entry, replication, and translation, is effective against Daclatasvir (HY-10466)-resistant strains, and exerts a synergistic effect when used in combination with Daclatasvir. Saikosaponin B2 is commonly used in studies related to hepatocellular carcinoma and HCV infection .

HY-N4211

Saikosaponin E	Others	Others
Saikosaponin E is a saikosaponin isolated from Bupleurum chinensis .

HY-N4218

Saikosaponin B4	Others	Metabolic Disease
Saikosaponin B4 is a member of saikosaponins isolated from the roots of Bupleurum chinensis, selectively inhibits ACTH-induced lipolysis .

HY-N2178

Saikosaponin F	Others	Inflammation/Immunology
Saikosaponin F is a component found in Bupleurum (B.) falcatum L .

HY-N7665

Prosaikogenin G	Others	Metabolic Disease
Prosaikogenin G, isolated from the roots of Bupleurum chinensis DC., exhibits significant inhibitory effects on rat mesangial cell proliferation induced by Ang II. Prosaikogenin G has protective action on the kidney . Prosaikogenin G is a derivative of Saikosaponin d in the gastrointestinal tract .

HY-N11670

11(α)-Hydroxynepasaikosaponin k	Others	Others
11(α)-Hydroxynepasaikosaponin k (compound HOSSc) is a saikosaponin that can be found in B. scorzonerifolium Willd .

HY-N2603

Saikosaponin H	Others	Inflammation/Immunology Cancer
Saikosaponin H is a saikosaponin derived from the herb Radix bupleuri .

HY-N4219

Saikosaponin B3	Others	Neurological Disease Metabolic Disease
Saikosaponin B3 is a saikosaponin isolated from the roots of Bupleurum falcatum L., with analgesic effect. Saikosaponin B3 inhibits ACTH-induced lipolysis in the fat cells .

HY-N0250R

Saikosaponin D (Standard)	Reference Standards STAT NF-κB Estrogen Receptor/ERR Bacterial	Infection Inflammation/Immunology Cancer
Saikosaponin D (Standard) is the analytical standard of Saikosaponin D. This product is intended for research and analytical applications. Saikosaponin D is a triterpene saponin isolated from Bupleurum, with anti-inflammatory, anti-bacterial, anti-tumor, and anti-allergic activities; Saikosaponin D inhibits selectin, STAT3 and NF-kB and activates estrogen receptor-β.

HY-N0246R

Saikosaponin A (Standard)	Reference Standards LXR Bacterial	Metabolic Disease Inflammation/Immunology
Saikosaponin A (Standard) is the analytical standard of Saikosaponin A. This product is intended for research and analytical applications. Saikosaponin A is the main active ingredient in Bupleurum chinense, which can regulate lipid metabolism and promote cholesterol efflux in early atherosclerosis. In addition, Saikosaponin A may also act as a potential peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist, significantly promoting the expression of PPAR-γ. Saikosaponin A can be used in the study of hyperlipidemic pancreatitis .

HY-N4216

Saikosaponin G	Others	Inflammation/Immunology
Saikosaponin G is a triterpene glycoside isolated from Bupleurum chinensis .

HY-N4217

Saikosaponin I	Others	Others
Saikosaponin I is a triterpene saponin extracted from Bupleurum falcatum L. Saikosaponin can be used to treat fever, inflammation, liver disease, and nephritis .

HY-N0249R

Saikosaponin C (Standard)	Reference Standards Amyloid-β	Neurological Disease
Saikosaponin C (Standard) is the analytical standard of Saikosaponin C. This product is intended for research and analytical applications. Saikosaponin C is a bioactive component found in radix bupleuri, targets amyloid beta and tau in Alzheimer's disease. Saikosaponin C inhibits the secretion of both Aβ1-40 and Aβ1-42, and suppresses abnormal tau phosphorylation, but shows no effect on BACE1 activity and expression .

HY-N0247R

Saikosaponin B1 (Standard)	Reference Standards Smo	Cancer
Saikosaponin B1 (Standard) is the analytical standard of Saikosaponin B1. This product is intended for research and analytical applications. Saikosaponin B1 is a bioactive constituent of Radix Bupleuri. Saikosaponin B1 is an agonist of the 5-HT_2C receptor with an EC₅₀ of 147.41 μM. Saikosaponin B1 inhibits the Hedgehog (Hh) signaling pathway by targeting the transmembrane protein SMO. Sailosaponin B1 can reduce liver fibrosis. Saikosaponin B1 has anti-cancer activities thus can be studies in research for cancers such as Medulloblastoma (MB) .

HY-N0248R

Saikosaponin B2 (Standard)	Reference Standards P-glycoprotein HCV	Infection Cancer
Saikosaponin B2 (Standard) is the analytical standard of Saikosaponin B2. This product is intended for research and analytical applications. Saikosaponin B2 is an antiviral and anticancer agent that regulates multiple transporters (such as various solute carriers and ATP-binding cassette transporters including MRP1, MRP2, and OCT2). Saikosaponin B2 is isolated from the plant glycoside component of the roots of Bupleurum scorzonerifolium. Saikosaponin B2 enhances the liver targeting of anticancer drugs via vinegar-baked Radix Bupleuri. Saikosaponin B2 inhibits HCV entry, replication, and translation, is effective against Daclatasvir (HY-10466)-resistant strains, and exerts a synergistic effect when used in combination with Daclatasvir. Saikosaponin B2 is commonly used in studies related to hepatocellular carcinoma and HCV infection .

HY-N11515

Saikosaponin S	Others	Others
Saikosaponin S is a natural product that can be isolated from Bupleurum scorzonerifolium .

HY-N12590

6′′-O-Acetylsaikosaponin b2	Others	Others
6′′-O-Acetylsaikosaponin b2 (compound 11) is a natural saikosaponin found in Bupleurum chinense .

HY-N9936

Saikosaponin S5 2''-O-acetylsaikosaponin A	Others	Others
Saikosaponin S5 (2''-O-acetylsaikosaponin A) is a Iridoids product that can be isolated from the barks of Ailanthus integrifolia .

HY-N7613

6''-O-Acetylsaikosaponin A	Others	Others
6''-O-Acetylsaikosaponin A, an acetyl saikosaponin isolated from the roots of Bupleurum chinense, shows some osteoclast-inhibiting activities .

HY-N17375

Saikosaponin bk1	NADPH Oxidase	Infection Metabolic Disease
Saikosaponin bk1 is a NADPH-oxidase 5(NOX5) dehydrogenase domain binder and hepatoprotective agent. Saikosaponin bk1 forms stable interactions with the dehydrogenase domain of NOX5 from Cylindrospermum stagnale. Saikosaponin bk1 is applicable to research related to COVID-19 and alcoholic liver injury .

HY-N17882

Hydroxysaikosaponin A Bupleuroside III	Drug Derivative	Others
Hydroxysaikosaponin A (Bupleuroside III) is the acid hydrolysis degradation product of Saikosaponin A (HY-N0246) .

HY-N9403

Prosaikogenin H	Others	Others
Prosaikogenin H is an intestinal metabolite of saikosaponin with a weak hemolytic activity .

HY-N9776

6''-O-Acetylsaikosaponin b3	Drug Derivative	Others
6''-O-Acetylsaikosaponin b3 is a natural triterpene.

HY-N19870

Verbascosaponin Ilwensisaponin A; Mimengoside A	Others	Inflammation/Immunology
Verbascosaponin (Ilwensisaponin A) is an orally active oleanane-triterpene saikosaponin found in crophularia auriculata ssp. pseudoauriculata. Verbascosaponin can be used for the research of inflammation .

HY-N17984

Hemsloside Ma3	Biochemical Assay Reagents	Others
Hemsloside Ma3 is an anionic surfactant and solubilizer. Hemsloside Ma3 is an oleanolic acid bisdesmosidic saponin that can be isolated from the rhizomes of Hemsleya macrosperma and Hemsleya chinensis. Hemsloside Ma3 improves the water solubility of saikosaponin a, a poorly water-soluble monodesmosidic saponin, and its solubilizing effect appears near the critical micelle concentration. At a constant ionic strength, Hemsloside Ma3 exhibits the property of reduced surface tension with the increase in hydrogen ion concentration .

Saikosaponin D Maximum Cited Publications 10 Publications Verification	Infection Triterpenes Classification of Application Fields Terpenoids Umbelliferae Plants Inflammation/Immunology Disease Research Fields Carphephorus corymbosus (Nutt.) Torr. & A.Gray Source Classification	STAT NF-κB Estrogen Receptor/ERR Bacterial
Saikosaponin D is a triterpene saponin isolated from Bupleurum, with anti-inflammatory, anti-bacterial, anti-tumor, and anti-allergic activities; Saikosaponin D inhibits selectin, STAT3 and NF-kB and activates estrogen receptor-β.

Saikosaponin A 5 Publications Verification	Triterpenes Classification of Application Fields Terpenoids Umbelliferae Plants Disease Research Fields Carphephorus corymbosus (Nutt.) Torr. & A.Gray Source Classification Cancer	LXR Bacterial
Saikosaponin A is the main active ingredient in Bupleurum chinense, which can regulate lipid metabolism and promote cholesterol efflux in early atherosclerosis. In addition, Saikosaponin A may also serve as a potential peroxisome proliferator-activated receptor γ (PPAR-γ) agonist, significantly promoting the expression of PPAR-γ. Saikosaponin A can be used in the study of hyperlipidemic pancreatitis .

Saikosaponin B1 2 Publications Verification	Structural Classification Classification of Application Fields Umbelliferae Plants Disease Research Fields Saccharides Monosaccharides Carphephorus corymbosus (Nutt.) Torr. & A.Gray Source Classification Cancer	Hedgehog Smo STAT Interleukin Related TNF Receptor
Saikosaponin B1 is a bioactive constituent of Radix Bupleuri. Saikosaponin B1 is an agonist of the 5-HT_2C receptor with an EC₅₀ of 147.41 μM. Saikosaponin B1 inhibits the Hedgehog (Hh) signaling pathway by targeting the transmembrane protein SMO. Sailosaponin B1 can reduce liver fibrosis. Saikosaponin B1 has anti-cancer activities thus can be studies in research for cancers such as Medulloblastoma (MB) .

Saikosaponin C 2 Publications Verification	Triterpenes Structural Classification Terpenoids Umbelliferae Plants Carphephorus corymbosus (Nutt.) Torr. & A.Gray Source Classification	MMP
Saikosaponin C is an orally active MMP-2 inducer. Saikosaponin C induces the survival, growth, migration and capillary tube formation of endothelial cells. Saikosaponin C inhibits the early stage of hepatitis C virus infection. Saikosaponin C can be used in research related to ischemic tissue diseases, chronic kidney diseases and hepatitis C virus infection .

Saikosaponin B2 2 Publications Verification	Infection Triterpenes Structural Classification Classification of Application Fields Terpenoids Umbelliferae Plants Disease Research Fields Carphephorus corymbosus (Nutt.) Torr. & A.Gray Source Classification	HCV P-glycoprotein
Saikosaponin B2 is an antiviral and anticancer agent that regulates multiple transporters (such as various solute carriers and ATP-binding cassette transporters including MRP1, MRP2, and OCT2). Saikosaponin B2 is isolated from the plant glycoside component of the roots of Bupleurum scorzonerifolium. Saikosaponin B2 enhances the liver targeting of anticancer drugs via vinegar-baked Radix Bupleuri. Saikosaponin B2 inhibits HCV entry, replication, and translation, is effective against Daclatasvir (HY-10466)-resistant strains, and exerts a synergistic effect when used in combination with Daclatasvir. Saikosaponin B2 is commonly used in studies related to hepatocellular carcinoma and HCV infection .

Saikosaponin E	Triterpenes Classification of Application Fields Terpenoids Other Diseases Plants Umbelliferae Disease Research Fields Source Classification Carphephorus corymbosus (Nutt.) Torr. & A.Gray	Others
Saikosaponin E is a saikosaponin isolated from Bupleurum chinensis .

Saikosaponin B4	Triterpenes Classification of Application Fields Terpenoids Metabolic Disease Plants Umbelliferae Disease Research Fields Source Classification Carphephorus corymbosus (Nutt.) Torr. & A.Gray	Others
Saikosaponin B4 is a member of saikosaponins isolated from the roots of Bupleurum chinensis, selectively inhibits ACTH-induced lipolysis .

Saikosaponin F	Triterpenes Classification of Application Fields Terpenoids Umbelliferae Plants Inflammation/Immunology Disease Research Fields Carphephorus corymbosus (Nutt.) Torr. & A.Gray Source Classification	Others
Saikosaponin F is a component found in Bupleurum (B.) falcatum L .

Prosaikogenin G	Triterpenes Classification of Application Fields Terpenoids Metabolic Disease Umbelliferae Plants Disease Research Fields Carphephorus corymbosus (Nutt.) Torr. & A.Gray Source Classification	Others
Prosaikogenin G, isolated from the roots of Bupleurum chinensis DC., exhibits significant inhibitory effects on rat mesangial cell proliferation induced by Ang II. Prosaikogenin G has protective action on the kidney . Prosaikogenin G is a derivative of Saikosaponin d in the gastrointestinal tract .

11(α)-Hydroxynepasaikosaponin k	Triterpenes Terpenoids Plants Umbelliferae Centratherum punctatum Cass. Source Classification	Others
11(α)-Hydroxynepasaikosaponin k (compound HOSSc) is a saikosaponin that can be found in B. scorzonerifolium Willd .

Saikosaponin H	Triterpenes Classification of Application Fields Terpenoids Plants Umbelliferae Disease Research Fields Cancer Source Classification Carphephorus corymbosus (Nutt.) Torr. & A.Gray	Others
Saikosaponin H is a saikosaponin derived from the herb Radix bupleuri .

Saikosaponin B3	Triterpenes Terpenoids Plants Umbelliferae Source Classification Carphephorus corymbosus (Nutt.) Torr. & A.Gray	Others
Saikosaponin B3 is a saikosaponin isolated from the roots of Bupleurum falcatum L., with analgesic effect. Saikosaponin B3 inhibits ACTH-induced lipolysis in the fat cells .

Saikosaponin D (Standard)	Triterpenes Structural Classification Terpenoids Umbelliferae Plants Carphephorus corymbosus (Nutt.) Torr. & A.Gray Source Classification	Reference Standards STAT NF-κB Estrogen Receptor/ERR Bacterial
Saikosaponin D (Standard) is the analytical standard of Saikosaponin D. This product is intended for research and analytical applications. Saikosaponin D is a triterpene saponin isolated from Bupleurum, with anti-inflammatory, anti-bacterial, anti-tumor, and anti-allergic activities; Saikosaponin D inhibits selectin, STAT3 and NF-kB and activates estrogen receptor-β.

Saikosaponin A (Standard)	Triterpenes Structural Classification Terpenoids Umbelliferae Plants Carphephorus corymbosus (Nutt.) Torr. & A.Gray Source Classification	Reference Standards LXR Bacterial
Saikosaponin A (Standard) is the analytical standard of Saikosaponin A. This product is intended for research and analytical applications. Saikosaponin A is the main active ingredient in Bupleurum chinense, which can regulate lipid metabolism and promote cholesterol efflux in early atherosclerosis. In addition, Saikosaponin A may also act as a potential peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist, significantly promoting the expression of PPAR-γ. Saikosaponin A can be used in the study of hyperlipidemic pancreatitis .

Saikosaponin G	Triterpenes Classification of Application Fields Terpenoids Plants Umbelliferae Inflammation/Immunology Disease Research Fields Source Classification Carphephorus corymbosus (Nutt.) Torr. & A.Gray	Others
Saikosaponin G is a triterpene glycoside isolated from Bupleurum chinensis .

Saikosaponin I	Triterpenes Terpenoids Launaea mucronata (Forssk.) Muschl. Plants Umbelliferae Source Classification	Others
Saikosaponin I is a triterpene saponin extracted from Bupleurum falcatum L. Saikosaponin can be used to treat fever, inflammation, liver disease, and nephritis .

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