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Cat. No.: HY-N19870

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Verbascosaponin

(Synonyms: Ilwensisaponin A; Mimengoside A)

Verbascosaponin (Ilwensisaponin A) is an orally active oleanane-triterpene saikosaponin found in crophularia auriculata ssp. pseudoauriculata. Verbascosaponin can be used for the research of inflammation.

For research use only. We do not sell to patients.

CAS No.: 141896-30-2
Formula: C₅₄H₈₈O₂₁
Molecular Weight:1073.26

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Verbascosaponin Chemical Structure

CAS No.: 141896-30-2

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Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vivo

Verbascosaponin (100 mg/kg; p.o.; single dose; 1 hour prior to inflammation induction) significantly inhibits Carrageenan (HY-125474)-induced mouse paw edema^[1].
Verbascosaponin (0.075-0.600 mg/ear; topical; single dose) potently inhibits single-dose TPA (HY-18739)-induced mouse ear edema with an ID₅₀ of 0.18 μmol/ear^[1].
Verbascosaponin (0.5 mg/ear; topical; single dose; 30 minutes prior to inflammation induction) does not produce appreciable inhibition of Arachidonic acid (HY-109590)-induced mouse ear edema, with only 4% reduction observed^[1].
Verbascosaponin (0.5 mg/ear; topical; single dose; 16 hours prior to inflammation induction) does not significantly inhibit Ethyl phenylpropiolate-induced mouse ear edema, with only 2% reduction observed^[1].
Verbascosaponin (0.5 mg/ear; topical; twice daily; 4 days) significantly inhibits TPA-induced chronic mouse ear edema by 58% and reduces neutrophil infiltration by 65%^[1].
Verbascosaponin (0.5 mg/ear; topical; doses at 6, 24, 48, 72, and 96 hours post-challenge) moderately inhibits Oxazolone (HY-126360)-induced delayed-type hypersensitivity mouse ear edema, with 32% reduction observed at 24 hours post-challenge, but does not reduce neutrophil infiltration^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Swiss mice (female, 25-30 g)^[1]
Dosage:

100 mg/kg
Administration:

p.o.; single dose; 1 hour prior to inflammation induction
Result:

Inhibited paw edema by >50% at 1 hour.
Showed slightly decreased inhibitory effects over time, with unspecified reduction values at 3 and 5 hours.

Animal Model:

Swiss mice (female, 25-30 g)^[1]
Dosage:

0.5 mg/ear
Administration:

topical; single dose
Result:

Achieved 72% edema inhibition of TPA (HY-18739)-induced ear edema.

Animal Model:

Swiss mice (female, 25-30 g)^[1]
Dosage:

0.5 mg/ear
Administration:

topical; single dose
Result:

Produced only 4% inhibition of Arachidonic acid-induced ear edema, an insignificant effect.

Animal Model:

Swiss mice (female, 25-30 g)^[1]
Dosage:

0.5 mg/ear
Administration:

topical; single dose; 16 hours prior to inflammation induction; simultaneous with inflammation induction
Result:

Reduced edema by only 2% (not significant) when administered 16 hours before ethyl phenylpropiolate.
Showed a slight inflammatory effect with no significant edema inhibition when administered simultaneously.

Animal Model:

Swiss mice (female, 25-30 g)^[1]
Dosage:

0.5 mg/ear
Administration:

topical; twice daily; 4 days
Result:

Reduced chronic ear edema by 58%.
Decreased neutrophil infiltration by 65%, as measured by myeloperoxidase activity.
Showed no or only mild inflammation, dermal fibrosis, increased fibroblasts, an epithelium thickness of 5.9 cells, and 15.5 mastocytes per 1000 μm² via histological analysis.

Animal Model:

Swiss mice (female, 25-30 g)^[1]
Dosage:

0.5 mg/ear
Administration:

topical; doses at 6, 24, 48, 72, and 96 hours post-challenge
Result:

Achieved 32% swelling inhibition at 24 hours post-challenge.
Showed no reduction in myeloperoxidase activity (no effect on neutrophil infiltration).

Chemical Information

CAS No. 141896-30-2
Molecular Weight 1073.26
Formula C₅₄H₈₈O₂₁
SMILES

C[C@]12[C@]3(C=C[C@@]4([H])[C@]2(CC[C@]5([H])[C@@]4(CC[C@@H]([C@@]5(C)CO)O[C@H]6[C@@H]([C@H]([C@H]([C@H](O6)C)O)O[C@@H]7O[C@@H]([C@H]([C@@H]([C@H]7O)O)O[C@H]8[C@@H]([C@@H]([C@H]([C@@H](O8)C)O)O)O)CO)O[C@@H]9O[C@@H]([C@H]([C@@H]([C@H]9O)O)O)CO)C)C)[C@@]%10([H])[C@@](CC1)(CCC(C)(C%10)C)CO3
Synonyms

Ilwensisaponin A; Mimengoside A
Structure Classification
- Terpenoids
- Triterpenes
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Giner RM, et al. Anti-inflammatory glycoterpenoids from Scrophularia auriculata. Eur J Pharmacol. 2000;389(2-3):243-252. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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