2. Others NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. Biochemical Assay Reagents Interleukin Related NF-κB Aminotransferases (Transaminases) Environmental Pollutants NO Synthase
  4. Sesame Oil

Sesame Oil is a vegetable oil. Sesame Oil can be extracted from the seeds of Sesamum indicum L. Sesame Oil decreases NF-κB, aspartate aminotransferase, alanine aminotransferase, IL-1β, IL-4 and nitric oxide. Sesame Oil has antitumor activity against malignant melanoma. Sesame Oil has protective effects against liver damage caused by various agents such as Cisplatin (HY-17394) and Acetaminophen (HY-66005). Sesame Oil shows antinociceptive and anti-inflammatory activities.

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Sesame Oil

Sesame Oil 화학구조

CAS No. : 8008-74-0

사이즈 가격 재고 수량
Solvent
50 mL 해외재고보유
Solvent
100 mL 해외재고보유
200 mL   견적 받기  
500 mL   견적 받기  

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고객리뷰

Based on 2 publication(s) in Google Scholar

Sesame Oil Related Antibodies

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  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

Sesame Oil is a vegetable oil. Sesame Oil can be extracted from the seeds of Sesamum indicum L. Sesame Oil decreases NF-κB, aspartate aminotransferase, alanine aminotransferase, IL-1β, IL-4 and nitric oxide. Sesame Oil has antitumor activity against malignant melanoma. Sesame Oil has protective effects against liver damage caused by various agents such as Cisplatin (HY-17394) and Acetaminophen (HY-66005). Sesame Oil shows antinociceptive and anti-inflammatory activities[1][2][3][4][5][6][7][8].

In Vitro

Sesame Oil (10-300 μg/mL; added on day 2 and cells harvested on day 5) selectively inhibits the growth of human malignant melanoma cells (SK-MEL)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sesame Oil Related Antibodies
In Vivo

Sesame Oil (0-4 mL/kg; p.o.; 6 h after MSU crystal injection) shows a potent therapeutic effect against Monosodium urate (MSU) (HY-B2130A) crystal-induced acute inflammatory response through inhibiting mast cell activation in rats[2].
Sesame Oil (8 mL/kg; p.o.; once; 6 h after endotoxin administration or cecal ligation and puncture (CLP)) reduces lipid peroxidation, decreases superoxide anion counts, increases glutathione levels, and increases the survival rate in septic rats[3].
Sesame Oil (100-400 mg/kg; p.o.) shows antinociceptive and anti-inflammatory activities in mice, reducing the number of abdominal contortions, inhibiting paw licking time in Formalin-induced nociception, increasing the reaction time, reducing paw edema and exudate volume, and inhibiting leucocyte migration[4].
Sesame Oil (2-8 mL/kg; p.o.; daily for 3 days) attenuates Cisplatin (HY-17394)-induced hepatic and renal injuries in mice by decreasing lipid peroxidation, production of hydroxyl radical, peroxynitrite, and nitrite in blood and tissue[5].
Sesame Oil (8 mL/kg; p.o.; once) protects rats against Acetaminophen (HY-66005)-induced acute liver injury by reversing APAP-altered parameters such as increasing aspartate and alanine aminotransferase levels[6].
Sesame Oil (8 mL/kg; p.o.; after Pb acetate plus LPS injection) protects against lead-plus-lipopolysaccharide (Pb + LPS)-induced acute hepatic injury in mice by decreasing serum aspartate aminotransferase and alanine aminotransferase levels, reducing TNF-α, IL-1β, and nitric oxide production in serum and liver tissue, and decreasing inducible nitric oxide synthase expression in leukocytes and liver tissue[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (weighing 200-250 g) + air-pouch model induced by injecting 24 mL of filtered sterile air subcutaneously and then MSU crystal (5 mg/rat) to induce inflammation[2]
Dosage: 0 mL/kg, 1 mL/kg, 2 mL/kg, 4 mL/kg
Administration: Oral gavage (p.o.), 6 h after MSU crystal injection
Result: Decreased MSU crystal-induced total cell counts, TNF-α, IL-1β, and IL-6 levels in lavage and pouch tissue.
Decreased leukocyte and neutrophil counts in lavage, activated mast cell counts in skin tissue, NF-κB activity and IL-4 level in isolated mast cells, and lavage complement proteins C3a and C5a levels.
Clinical Trial
CAS No.
Appearance

Liquid (Density: 0.919 g/cm3)

Color

Colorless to light yellow

SMILES

[Sesame Oil]
선적

Room temperature in continental US; may vary elsewhere.
보관
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
용액&용해도
In Vitro: 

DMSO : 200 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL; Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서

Purity: 98.2%

SDS (251 KB)

COA (244 KB)

Handling Instructions (2659 KB)
References
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Sesame Oil Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sesame Oil8008-74-0Biochemical Assay ReagentsInterleukin RelatedNF-κBAminotransferases (Transaminases)Environmental PollutantsNO SynthaseILNuclear factor-κBNuclear factor-kappaBAminotransferases (Transaminases) Environmental ContaminantsNitric oxide synthasesNOSOil-soluble substance carriersolventacute inflammatoryantinociceptiveInhibitorinhibitorinhibit

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상품명:
Sesame Oil
Cat. No.:
HY-154629
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