2. Others NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. Biochemical Assay Reagents Interleukin Related NF-κB Aminotransferases (Transaminases) Environmental Pollutants NO Synthase
  4. Sesame Oil

Sesame Oil  (Synonyms: ゴマ油)

製品番号: HY-154629 Assay: 98.2%
COA 取扱説明書 Technical Support

Sesame Oil is a vegetable oil. Sesame Oil can be extracted from the seeds of Sesamum indicum L. Sesame Oil decreases NF-κB, aspartate aminotransferase, alanine aminotransferase, IL-1β, IL-4 and nitric oxide. Sesame Oil has antitumor activity against malignant melanoma. Sesame Oil has protective effects against liver damage caused by various agents such as Cisplatin (HY-17394) and Acetaminophen (HY-66005). Sesame Oil shows antinociceptive and anti-inflammatory activities.

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Sesame Oil

Sesame Oil 構造式

CAS 番号 : 8008-74-0

容量 価格（税別） 在庫状況 数量
Solvent
50 mL USD 40 在庫あり
Solvent
100 mL USD 70 在庫あり
200 mL   お問い合わせ  
500 mL   お問い合わせ  

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カスタマーレビュー

Based on 2 publication(s) in Google Scholar

Sesame Oil 関連抗体

Top Publications Citing Use of Products

Interleukin Related アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

NF-κB アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

Aminotransferases (Transaminases) アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
GPT/ALT GOT/AST

NO Synthase アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
nNOS iNOS eNOS

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

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製品説明

Sesame Oil is a vegetable oil. Sesame Oil can be extracted from the seeds of Sesamum indicum L. Sesame Oil decreases NF-κB, aspartate aminotransferase, alanine aminotransferase, IL-1β, IL-4 and nitric oxide. Sesame Oil has antitumor activity against malignant melanoma. Sesame Oil has protective effects against liver damage caused by various agents such as Cisplatin (HY-17394) and Acetaminophen (HY-66005). Sesame Oil shows antinociceptive and anti-inflammatory activities[1][2][3][4][5][6][7][8].

体外実験

Sesame Oil (10-300 μg/mL; added on day 2 and cells harvested on day 5) selectively inhibits the growth of human malignant melanoma cells (SK-MEL)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sesame Oil 関連抗体
体内実験

Sesame Oil (0-4 mL/kg; p.o.; 6 h after MSU crystal injection) shows a potent therapeutic effect against Monosodium urate (MSU) (HY-B2130A) crystal-induced acute inflammatory response through inhibiting mast cell activation in rats[2].
Sesame Oil (8 mL/kg; p.o.; once; 6 h after endotoxin administration or cecal ligation and puncture (CLP)) reduces lipid peroxidation, decreases superoxide anion counts, increases glutathione levels, and increases the survival rate in septic rats[3].
Sesame Oil (100-400 mg/kg; p.o.) shows antinociceptive and anti-inflammatory activities in mice, reducing the number of abdominal contortions, inhibiting paw licking time in Formalin-induced nociception, increasing the reaction time, reducing paw edema and exudate volume, and inhibiting leucocyte migration[4].
Sesame Oil (2-8 mL/kg; p.o.; daily for 3 days) attenuates Cisplatin (HY-17394)-induced hepatic and renal injuries in mice by decreasing lipid peroxidation, production of hydroxyl radical, peroxynitrite, and nitrite in blood and tissue[5].
Sesame Oil (8 mL/kg; p.o.; once) protects rats against Acetaminophen (HY-66005)-induced acute liver injury by reversing APAP-altered parameters such as increasing aspartate and alanine aminotransferase levels[6].
Sesame Oil (8 mL/kg; p.o.; after Pb acetate plus LPS injection) protects against lead-plus-lipopolysaccharide (Pb + LPS)-induced acute hepatic injury in mice by decreasing serum aspartate aminotransferase and alanine aminotransferase levels, reducing TNF-α, IL-1β, and nitric oxide production in serum and liver tissue, and decreasing inducible nitric oxide synthase expression in leukocytes and liver tissue[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (weighing 200-250 g) + air-pouch model induced by injecting 24 mL of filtered sterile air subcutaneously and then MSU crystal (5 mg/rat) to induce inflammation[2]
Dosage: 0 mL/kg, 1 mL/kg, 2 mL/kg, 4 mL/kg
Administration: Oral gavage (p.o.), 6 h after MSU crystal injection
Result: Decreased MSU crystal-induced total cell counts, TNF-α, IL-1β, and IL-6 levels in lavage and pouch tissue.
Decreased leukocyte and neutrophil counts in lavage, activated mast cell counts in skin tissue, NF-κB activity and IL-4 level in isolated mast cells, and lavage complement proteins C3a and C5a levels.
臨床実験
CAS 番号
Appearance

Liquid (Density: 0.919 g/cm3)

Color

Colorless to light yellow

SMILES

[Sesame Oil]
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Pure form -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 200 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL; Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション

純度: 98.2%

COA (244 KB)

取扱説明書 (2659 KB)
参考文献
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Sesame Oil Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sesame Oil8008-74-0Biochemical Assay ReagentsInterleukin RelatedNF-κBAminotransferases (Transaminases)Environmental PollutantsNO SynthaseILNuclear factor-κBNuclear factor-kappaBAminotransferases (Transaminases) Environmental ContaminantsNitric oxide synthasesNOSOil-soluble substance carriersolventacute inflammatoryantinociceptiveInhibitorinhibitorinhibit

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