2. Cell Cycle/DNA Damage Anti-infection
  3. DNA Alkylator/Crosslinker Antibiotic
  4. Sibiromycin

Sibiromycin is a naturally produced glycosylated pyrrolobenzodiazepines (PBDs). Sibiromycin is also a potent antitumor antibiotic that binds covalently to DNA in the minor groove at the NH2 of guanine.

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Sibiromycin

Sibiromycin Estructura química

No. CAS : 12684-33-2

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5 mg Pide un presupuesto y un plazo de entrega

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Sibiromycin Related Antibodies

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Descripciòn

Sibiromycin is a naturally produced glycosylated pyrrolobenzodiazepines (PBDs). Sibiromycin is also a potent antitumor antibiotic that binds covalently to DNA in the minor groove at the NH2 of guanine[1][2].

Cellular Effect
Cell Line Type Value Description References
K562 IC50
0.0014 μM
Compound: 2
Cytotoxicity against human K562 cells after 96 hrs by alamar blue assay
Cytotoxicity against human K562 cells after 96 hrs by alamar blue assay
[PMID: 20218628]
In Vitro

Pyrrolobenzodiazepines (PBDs) are sequence selective DNA alkylating agents with remarkable antineoplastic activity[1].
Alkylation of DNA by anthramycin, sibiromycin and tomaymycin is sequence specific with the following trend for binding preference 5′-Pu-G-Pu>5′-Py-G-Pu>5′-Pu-G-Py>5′-Py-G-Py[1].
Sibiromycin shows cytotoxicity against L1210 (leukemia), ADJ/PC6 (plasmacytoma) and CH1 (ovarian) cells with IC50s of ranging 0.000017 ~0.0029 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sibiromycin Related Antibodies
Peso molecular

475.53

Fòrmula

C24H33N3O7
No. CAS
SMILES

O=C1C2=CC(O[C@H]3[C@@H]([C@](O)([C@H]([C@@H](O3)C)NC)C)O)=C(C)C(O)=C2N[C@@H]([C@@]4([H])N1C=C(C4)/C=C/C)O
Structure Classification
Initial Source

Streptosporangium sibiricum
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
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Sibiromycin Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sibiromycin12684-33-2DNA Alkylator/CrosslinkerAntibioticpyrrolobenzodiazepinesantitumorgrooveDNAguaninealkylatingInhibitorinhibitorinhibit

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Nombre del producto:
Sibiromycin
Cat. No.:
HY-N9460
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