1. Flavonoids
  2. Silychristin

Silychristin 

Cat. No.: HY-N0647 Purity: 99.65%
Handling Instructions

Silychristin is an abundant flavonolignan present in the fruits of Silybum marianum, with antioxidant properties. Silychristin is a potent inhibitor of the thyroid hormone transporter MCT8, and elicits a strong inhibition of T3 uptake with an IC50 of 110 nM.

For research use only. We do not sell to patients.

Silychristin Chemical Structure

Silychristin Chemical Structure

CAS No. : 33889-69-9

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10 mM * 1 mL in DMSO USD 85 In-stock
Estimated Time of Arrival: December 31
1 mg USD 50 In-stock
Estimated Time of Arrival: December 31
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10 mg USD 120 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Silychristin is an abundant flavonolignan present in the fruits of Silybum marianum, with antioxidant properties. Silychristin is a potent inhibitor of the thyroid hormone transporter MCT8, and elicits a strong inhibition of T3 uptake with an IC50 of 110 nM[1][2].

IC50 & Target

MCT8[2]

In Vitro

Silychristin exhibits a strong inhibition of MCT8-mediated T3 uptake with an IC50 of 110 nM in MCT8 overexpressing MDCK1-cells[2].
Silychristin causes no cytotoxic for fibroblasts[3].
Silychristin (6.5-75 μM; 24 hours) diminishes UVA toxicity and reduces ROS generation, and the protective effect is dose-dependent[3].
Silychristin (12.5μM, 25μM) reduces the metalloproteinase-1 (MMP-1) level in cells[3].

Cell Viability Assay[3]

Cell Line: NHDF
Concentration: 6.5 μM,12.5 μM,25 μM,50 μM,75 μM
Incubation Time: 24 hours
Result: Diminished UVA toxicity and reduced ROS generation in dose-dependent.

Cell Viability Assay [3]

Cell Line: NHDF
Concentration: 12.5 μM, 25 μM
Incubation Time:
Result: Reduced the metalloproteinase-1 (MMP-1) level in cells.
Molecular Weight

482.44

Formula

C₂₅H₂₂O₁₀

CAS No.

33889-69-9

SMILES

O=C1[[email protected]](O)[[email protected]@H](C2=CC(O)=C(O[[email protected]@H](C3=CC=C(O)C(OC)=C3)[[email protected]@H]4CO)C4=C2)OC5=CC(O)=CC(O)=C15

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
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Silychristin
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