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  4. Silybum marianum (L.) Gaertn.
    Silybum marianum (Linn.) Gaertn
  5. Silychristin

Silychristin 

Cat. No.: HY-N0647 Purity: 98.48%
Handling Instructions

Silychristin is an abundant flavonolignan present in the fruits of Silybum marianum, with antioxidant properties. Silychristin is a potent inhibitor of the thyroid hormone transporter MCT8, and elicits a strong inhibition of T3 uptake with an IC50 of 110 nM.

For research use only. We do not sell to patients.

Silychristin Chemical Structure

Silychristin Chemical Structure

CAS No. : 33889-69-9

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 94 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 94 In-stock
Estimated Time of Arrival: December 31
Solid
1 mg USD 55 In-stock
Estimated Time of Arrival: December 31
5 mg USD 88 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Silychristin is an abundant flavonolignan present in the fruits of Silybum marianum, with antioxidant properties. Silychristin is a potent inhibitor of the thyroid hormone transporter MCT8, and elicits a strong inhibition of T3 uptake with an IC50 of 110 nM[1][2].

IC50 & Target

MCT8[2]

In Vitro

Silychristin exhibits a strong inhibition of MCT8-mediated T3 uptake with an IC50 of 110 nM in MCT8 overexpressing MDCK1-cells[2].
Silychristin causes no cytotoxic for fibroblasts[3].
Silychristin (6.5-75 μM; 24 hours) diminishes UVA toxicity and reduces ROS generation, and the protective effect is dose-dependent[3].
Silychristin (12.5μM, 25μM) reduces the metalloproteinase-1 (MMP-1) level in cells[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[3]

Cell Line: NHDF
Concentration: 6.5 μM,12.5 μM,25 μM,50 μM,75 μM
Incubation Time: 24 hours
Result: Diminished UVA toxicity and reduced ROS generation in dose-dependent.

Cell Viability Assay [3]

Cell Line: NHDF
Concentration: 12.5 μM, 25 μM
Incubation Time:
Result: Reduced the metalloproteinase-1 (MMP-1) level in cells.
Molecular Weight

482.44

Formula

C25H22O10

CAS No.
SMILES

O=C1[[email protected]](O)[[email protected]@H](C2=CC(O)=C(O[[email protected]@H](C3=CC=C(O)C(OC)=C3)[[email protected]@H]4CO)C4=C2)OC5=CC(O)=CC(O)=C15

Structure Classification
Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (207.28 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0728 mL 10.3640 mL 20.7280 mL
5 mM 0.4146 mL 2.0728 mL 4.1456 mL
10 mM 0.2073 mL 1.0364 mL 2.0728 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.18 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.18 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.18 mM); Clear solution

*All of the co-solvents are available by MCE.
References
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Product Name:
Silychristin
Cat. No.:
HY-N0647
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