2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. SKF 38393 hydrochloride

SKF 38393 hydrochloride  (Synonyms: (±)-SKF-38393 hydrochloride; SKF-38393A)

Cat. No.: HY-12520A Purity: 99.49%
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SKF 38393 hydrochloride is a selective agonist of the dopamine D1 receptor (D1DR) with an IC50 of 110 nM.

For research use only. We do not sell to patients.

CAS No. : 62717-42-4

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
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100 mg In-stock
200 mg In-stock
500 mg In-stock
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Customer Review

Based on 20 publication(s) in Google Scholar

Other Forms of SKF 38393 hydrochloride:

SKF 38393 hydrochloride Related Antibodies

Top Publications Citing Use of Products

    SKF 38393 hydrochloride purchased from MedChemExpress. Usage Cited in: J Clin Invest. 2026 Jan 15;136(5):e196944.  [Abstract]

    SKF 38393 hydrochloride (1 mg/mL; 5 min). Analysis of CPP behavior of METH-exposed male mice and representative heatmap of time spent in CPP apparatus.

    SKF 38393 hydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Aug 23:e03409.  [Abstract]

    SKF 38393 hydrochloride (10 μM) significantly increased frequency and amplitude of mEPSCsin the MN + SKF group.

    SKF 38393 hydrochloride purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2025 May 6.  [Abstract]

    SKF 38393 hydrochloride (SKF) (1 μM; 300 nL; i.t.) significantly increased the duration in the center area of the open field arena and the open arms of the EPM and shortened immobility time in the TST and FST in C57BL/6J mice subjected to 6-OHDA injection in the MFB.

    SKF 38393 hydrochloride purchased from MedChemExpress. Usage Cited in: J Affect Disord. 2024 Jul 1:356:586-596.  [Abstract]

    SKF 38393 hydrochloride (SKF) (10 mg/kg; i.p.) significantly upregulated D1R proteins and downregulated NLRP3 signaling pathway-related proteins in the hippocampus of DD (diabetes mellitus with depression) rats.

    SKF 38393 hydrochloride purchased from MedChemExpress. Usage Cited in: Microbiome. 2020 Aug 20;8(1):120.  [Abstract]

    After the injection of D1R agonist SKF 38393 hydrochloride (0.0625 μg/0.3 μL; 30 min) in mPFC of 8-week-old male KO mice, olfactory habituation/dishabituation test or three-chambered social approach task was conducted with an interval of 1 week.

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    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    SKF 38393 hydrochloride is a selective agonist of the dopamine D1 receptor (D1DR) with an IC50 of 110 nM[1].

    IC50 & Target

    D1 Receptor

     

    In Vitro

    SKF-38393 hydrochloride induces a similar change in cytomorphology and increases the levels of media cAMP[2].
    SKF-38393 hydrochloride (10 μmol/L; 1 hour) induces increased threonine-phosphorylation of DA- and cAMP-regulated phosphoprotein of Mr 32 kD (DARPP-32) in cultured GC cells[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    SKF 38393 hydrochloride Related Antibodies

    Western Blot Analysis[2].

    Cell Line: GC cells
    Concentration: 10 μmol/L
    Incubation Time: 1 hour
    Result: Induced increased threonine-phosphorylation of DA- and cAMP-regulated phosphoprotein of Mr 32 kD (DARPP-32) in cultured GC cells.
    In Vivo

    SKF-38393 hydrochloride (10 mg/kg; i.p.) blocks the 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) -induced depletion of glutathione[3].
    SKF-38393 hydrochloride attenuates MPTP-induced depletion of dopamine[3].
    SKF-38393 hydrochloride enhances the activity of superoxide dismutase and hence mimics the action of Selegiline[3].
    SKF-38393 hydrochloride enhances the frequency but not the amplitude of tetrodotoxin-resistant excitatory postsynaptic currents which argues for a presynaptic locus of D1 action[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Balb/c mice ( 20-25 g)[3].
    Dosage: 5 mg/kg, 10 mg/kg
    Administration: Intraperitoneal injection
    Result: Blocked the MPTP-induced depletion of glutathione and attenuated MPTP-induced depletion of dopamine.
    Molecular Weight

    291.77

    Formula

    C16H18ClNO2
    CAS No.
    Appearance

    Solid

    Color

    Light yellow to khaki

    SMILES

    OC1=C(O)C=C2C(C3=CC=CC=C3)CNCCC2=C1.[H]Cl
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    DMSO : 125 mg/mL (428.42 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : 10 mg/mL (34.27 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.4274 mL 17.1368 mL 34.2736 mL
    5 mM 0.6855 mL 3.4274 mL 6.8547 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.08 mg/mL (7.13 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.08 mg/mL (7.13 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation

    Purity: 99.49%

    SDS (393 KB)

    COA (256 KB) RP-HPLC (259 KB) MS (68 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 3.4274 mL 17.1368 mL 34.2736 mL 85.6839 mL
    5 mM 0.6855 mL 3.4274 mL 6.8547 mL 17.1368 mL
    10 mM 0.3427 mL 1.7137 mL 3.4274 mL 8.5684 mL
    15 mM 0.2285 mL 1.1425 mL 2.2849 mL 5.7123 mL
    20 mM 0.1714 mL 0.8568 mL 1.7137 mL 4.2842 mL
    25 mM 0.1371 mL 0.6855 mL 1.3709 mL 3.4274 mL
    30 mM 0.1142 mL 0.5712 mL 1.1425 mL 2.8561 mL
    DMSO 40 mM 0.0857 mL 0.4284 mL 0.8568 mL 2.1421 mL
    50 mM 0.0685 mL 0.3427 mL 0.6855 mL 1.7137 mL
    60 mM 0.0571 mL 0.2856 mL 0.5712 mL 1.4281 mL
    80 mM 0.0428 mL 0.2142 mL 0.4284 mL 1.0710 mL
    100 mM 0.0343 mL 0.1714 mL 0.3427 mL 0.8568 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    SKF 38393 hydrochloride Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    SKF 3839362717-42-4(±)-SKF-38393 SKF-38393ASKF38393SKF-38393Dopamine ReceptorInhibitorinhibitorinhibit

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