2. Cell Cycle/DNA Damage Apoptosis
  3. RAD51 MDM-2/p53
  4. Solanidine

Solanidine  (Synonyms: ソラニジン)

製品番号: HY-N7271 純度: 99.90%
COA 取扱説明書 Technical Support

Solanidine is an orally active cholestane alkaloid. Solanidine can be isolated from potato. Solanidine decreases RAD51 and increases γH2AX and p53. Solanidine has anti-tumor effects on LLC tumors and lung cancer. Solanidine promotes breast cancer cell proliferation. Solanidine reduces neovascularization. Solanidine causes abortion in some pregnant mice.

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Solanidine

Solanidine 構造式

CAS 番号 : 80-78-4

容量 価格（税別） 在庫状況 数量
1 mg $110 在庫あり
5 mg $350 在庫あり
10 mg $600 在庫あり
50 mg   お問い合わせ  
100 mg   お問い合わせ  

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Based on 1 publication(s) in Google Scholar

Other Forms of Solanidine:

Solanidine 関連抗体

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  • 生物活性

  • 純度とドキュメンテーション

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製品説明

Solanidine is an orally active cholestane alkaloid. Solanidine can be isolated from potato. Solanidine decreases RAD51 and increases γH2AX and p53. Solanidine has anti-tumor effects on LLC tumors and lung cancer. Solanidine promotes breast cancer cell proliferation. Solanidine reduces neovascularization. Solanidine causes abortion in some pregnant mice[1][2][3].

体外実験

Solanidine (10 μM) increases the proliferation of MCF-7 human breast cancer cells in the estrogen-depleted condition[1].
Solanidine (4-8 μM; 48 h) induces DNA damage in A549 cells and reduces the migration and invasion of A549 cells under hypoxic conditions[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Solanidine 関連抗体

Western Blot Analysis[2]

Cell Line: A549 cells
Concentration: 4 μM, 8 μM
Incubation Time: 48 h
Result: Decreased the expression of RAD51, elevated the expression of γH2AX, and increased the expression of tumor suppressor protein p53.
Inhibited the phosphorylation of ATMser1981, HIF-1αser696, and Chk2Tyr68.
体内実験

Solanidine (2.4 mmol/kg; p.o., dietary administration; 14 days) causes hepatomegaly in non-pregnant and pregnant mice, reduces body weight gains, litter weights, and average fetus weights in pregnant mice, and leads to abortions in some pregnant mice[1].
Solanidine (4-8 μM; topical application; 7 days) reduces neovascularization in the alkali burn corneal model of rats[2].
Solanidine (10-20 mg/kg; i.p.; every other day; 6 doses) regresses LLC tumor in Balb/C female mice, reduces the number of tumor nodules, and extends the survival of animals[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss Webster mice (female, 25-36 g, timed-pregnant at 1-2 days’ gestation) pregnant mice model[1]
Dosage: 2.4 mmol/kg (in diet)
Administration: Dietary administration, 14 days
Result: Led to lower body weight gains, litter weights, and average fetus weights in pregnant mice.
Resulted in miscarriage in 5 of 24 pregnant mice.
Increased liver weight as a percentage of body weight (%LW/BW) in non-pregnant and pregnant mice.
Showed lower litter weight as a percentage of body weight (%LTW/BW).
分子量

397.64

分子式

C27H43NO
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

[H][C@@]12CC=C3C[C@@H](O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@@]5([H])[C@H](C)[C@@]6([H])CC[C@H](C)CN6[C@]([H])5C[C@@]24[H]
Structure Classification
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

Ethanol : 3.33 mg/mL (8.37 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5148 mL 12.5742 mL 25.1484 mL
5 mM 0.5030 mL 2.5148 mL 5.0297 mL
10 mM --- --- ---
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

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体積 （開始）

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション

純度: 99.90%

COA (249 KB) HNMR (260 KB) RP-HPLC (237 KB) MS (80 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol 1 mM 2.5148 mL 12.5742 mL 25.1484 mL 62.8709 mL
5 mM 0.5030 mL 2.5148 mL 5.0297 mL 12.5742 mL
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Solanidine Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Solanidine80-78-4RAD51MDM-2/p53cholestanealkaloidpotatospeciesSolanumdemissumacauletuberosumproliferationantitumorInhibitorinhibitorinhibit

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