80-78-4
80-78-4
Chemical Structure
Solanidine
- CAS No.: 80-78-4
- Formula:C27H43NO
- Molecular Weight:397.64
IUPAC Name: (4S,6aR,6bS,8aS,8bR,9S,9aR,12S,14aS,15aS,15bS)-6a,8a,9,12-tetramethyl-3,4,5,6,6a,6b,7,8,8a,8b,9,9a,10,11,12,13,14a,15,15a,15b-icosahydro-1H-naphtho[2',1':4,5]indeno[1,2-b]indolizin-4-ol
InChIKey: JVKYZPBMZPJNAJ-OQFNDJACSA-N
SMILES: [H][C@@]12CC=C3C[C@@H](O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@@]5([H])[C@H](C)[C@@]6([H])CC[C@H](C)CN6[C@]([H])5C[C@@]24[H]
Biological Activity: Solanidine is an orally active cholestane alkaloid. Solanidine can be isolated from potato. Solanidine decreases RAD51 and increases γH2AX and p53. Solanidine has anti-tumor effects on LLC tumors and lung cancer. Solanidine promotes breast cancer cell proliferation. Solanidine reduces neovascularization. Solanidine causes abortion in some pregnant mice[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Solanidine | 99.90% | Solanidine is an orally active cholestane alkaloid. Solanidine can be isolated from potato. Solanidine decreases RAD51 and increases γH2AX and p53. Solanidine has anti-tumor effects on LLC tumors and lung cancer. Solanidine promotes breast cancer cell proliferation. Solanidine reduces neovascularization. Solanidine causes abortion in some pregnant mice. | ||||||||||||||||||||
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Solanidine (Standard) | ≥98% | Solanidine (Standard) is the analytical standard of Solanidine. This product is intended for research and analytical applications. Solanidine is an orally active cholestane alkaloid. Solanidine can be isolated from potato. Solanidine decreases RAD51 and increases γH2AX and p53. Solanidine has anti-tumor effects on LLC tumors and lung cancer. Solanidine promotes breast cancer cell proliferation. Solanidine reduces neovascularization. Solanidine causes abortion in some pregnant mice. | ||||||||||||||||||||
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Hapepunine | 99.61% | Hapepunine is a N-methyl-22,26-epiminochole stene, that can be isaolated from the aerial parts of Fritillaria camtschatcensis. | ||||||||||||||||||||
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20β-22-Azacholesterol | 20β-22-Azacholesterol is the β-configuration of 22-Azacholesterol (HY-113630). 20β-22-Azacholesterol is an inhibitor for cholesterol side chain cleavage reactions. | |||||||||||||||||||||
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(3β)-Con-5-enin-3-ol | (3β)-Con-5-enin-3-ol (Compound 21) is a sterol. | |||||||||||||||||||||
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Azacosterol dihydrochloride | Azacosterol (SC-12937) dihydrochloride is a chemosterilant which in-hibits reproduction in the pigeon. Azacosterol (SC-12937) dihydrochloride exerts its inhibitory effect through the blocking of the synthesis of cholesterol, thought to be a vital component in the formation of egg yolks. | |||||||||||||||||||||
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Azacosterol | 99.85% | Azacosterol (20.25-Diazacholesterol), also known as Diazasterol, acts as a DHCR24 inhibitor and initiates a cascade of reactions in cortical neurons after being administered orally or via intraperitoneal injection. | ||||||||||||||||||||
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Solasodine | 99.97% | Solasodine (Purapuridine) is a steroidal alkaloid that occurs in plants of the Solanaceae family. Solasodine induces apoptosis by inhibiting the p53-MDM2 complex, p21Waf1/Cip1, and Bcl-2 proteins. Solasodine has neuroprotective, antifungal, hypotensive, anticancer, antiatherosclerotic, antiandrogenic and anti-inflammatory activities. | ||||||||||||||||||||
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Verazine | 99.74% | Verazine ((-)-Verazine) is an anti-Fungal Agent that can be found in the dried roots and rhizoma of Veratrum maackii Regel. Verazine causes DNA damage in the cerebellum and cerebral cortex of mice in a dose-dependent manner. Verazine can be used in the study of fungal infections and neurological diseases. | ||||||||||||||||||||
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Solanidiene | Solanidiene (Solanthrene) is isolated from the leaves of S. tuberosum. | |||||||||||||||||||||
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Demissidine | 95% | Demissidine is an alkaloid aglycone that can be isolated from Solanum tuberosum. Demissidine is a dual inhibitor candidate that shows activity against β-secretase and γ-secretase in silico. Demissidine has antibacterial and antiparasitic activities. Demissidine also has weak anticancer and acetylcholinesterase (AChE) inhibitory activities. Demissidine can be used in research on colon cancer, liver cancer, Alzheimer's disease, and Chagas disease. | ||||||||||||||||||||
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Solasodine hydrochloride | Solasodine (Purapuridine) hydrochloride is a steroidal alkaloid that occurs in plants of the Solanaceae family. Solasodine hydrochloride induces apoptosis by inhibiting the p53-MDM2 complex, p21Waf1/Cip1, and Bcl-2 proteins. Solasodine hydrochloride has neuroprotective, antifungal, hypotensive, anticancer, antiatherosclerotic, antiandrogenic and anti-inflammatory activities. | |||||||||||||||||||||
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References
- [1]. Friedman M, et al. Effect of feeding solanidine, solasodine and tomatidine to non-pregnant and pregnant mice. Food Chem Toxicol. 2003 Jan;41(1):61-71. [Content Brief]
- [2]. Sherapura A, et al. Steroidal alkaloid solanidine impedes hypoxia-driven ATM phosphorylation to switch on anti-angiogenesis in lung adenocarcinoma. Phytomedicine. 2023 Oct;119:154981. [Content Brief]
- [3]. Zhang ZD, et al. Synthesis of Demissidine and Solanidine.Org Lett. 2016 Jun 17;18(12):3038-40. [Content Brief]
