80-78-4
Chemical Structure
Solanidine
- CAS No.: 80-78-4
- Formula:C27H43NO
- Molecular Weight:397.64
IUPAC Name: (4S,6aR,6bS,8aS,8bR,9S,9aR,12S,14aS,15aS,15bS)-6a,8a,9,12-tetramethyl-3,4,5,6,6a,6b,7,8,8a,8b,9,9a,10,11,12,13,14a,15,15a,15b-icosahydro-1H-naphtho[2',1':4,5]indeno[1,2-b]indolizin-4-ol
InChIKey: JVKYZPBMZPJNAJ-OQFNDJACSA-N
SMILES: [H][C@@]12CC=C3C[C@@H](O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@@]5([H])[C@H](C)[C@@]6([H])CC[C@H](C)CN6[C@]([H])5C[C@@]24[H]
Biological Activity: Solanidine is an orally active cholestane alkaloid. Solanidine can be isolated from potato. Solanidine decreases RAD51 and increases γH2AX and p53. Solanidine has anti-tumor effects on LLC tumors and lung cancer. Solanidine promotes breast cancer cell proliferation. Solanidine reduces neovascularization. Solanidine causes abortion in some pregnant mice[1][2][3].
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Solanidine | 99.90% | Solanidine is an orally active cholestane alkaloid. Solanidine can be isolated from potato. Solanidine decreases RAD51 and increases γH2AX and p53. Solanidine has anti-tumor effects on LLC tumors and lung cancer. Solanidine promotes breast cancer cell proliferation. Solanidine reduces neovascularization. Solanidine causes abortion in some pregnant mice. | ||||||||||||||||||||
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Solanidine (Standard) | ≥98% | Solanidine (Standard) is the analytical standard of Solanidine. This product is intended for research and analytical applications. Solanidine is an orally active cholestane alkaloid. Solanidine can be isolated from potato. Solanidine decreases RAD51 and increases γH2AX and p53. Solanidine has anti-tumor effects on LLC tumors and lung cancer. Solanidine promotes breast cancer cell proliferation. Solanidine reduces neovascularization. Solanidine causes abortion in some pregnant mice. | ||||||||||||||||||||
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- [1]. Friedman M, et al. Effect of feeding solanidine, solasodine and tomatidine to non-pregnant and pregnant mice. Food Chem Toxicol. 2003 Jan;41(1):61-71. [Content Brief]
- [2]. Sherapura A, et al. Steroidal alkaloid solanidine impedes hypoxia-driven ATM phosphorylation to switch on anti-angiogenesis in lung adenocarcinoma. Phytomedicine. 2023 Oct;119:154981. [Content Brief]
- [3]. Zhang ZD, et al. Synthesis of Demissidine and Solanidine.Org Lett. 2016 Jun 17;18(12):3038-40. [Content Brief]
Keywords
