2. PROTAC JAK/STAT Signaling Stem Cell/Wnt
  3. PROTACs STAT
  4. SD-91

SD-91 (STAT3 degrader-2), a product of the hydrolysis of SD-36 (HY-129602), is a selective PROTAC-based STAT3 degrader with a Ki of 5.5 nM. SD-91 displays >300-fold selectivity over other STAT family protein members. SD-91 potently induces degradation of STAT3 protein in cells. SD-91 has anticancer effects, such as myeloid leukemia, lymphoma (Pink: ligand for target protein (HY-150895); Black: linker; Blue: E3 ligase ligand; E3 ligase ligand+linker: HY-176506).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

SD-91

SD-91 화학구조

CAS No. : 2497583-03-4

사이즈 가격 재고 수량
1 mg 해외재고보유
5 mg 해외재고보유
10 mg 해외재고보유
25 mg 해외재고보유
50 mg   견적 받기  
100 mg   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

SD-91 Related Antibodies

Top Publications Citing Use of Products

View All PROTACs Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

View All STAT Isoform Specific Products:

View All Isoforms
STAT3 STAT5 STAT6 STAT1

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

SD-91 (STAT3 degrader-2), a product of the hydrolysis of SD-36 (HY-129602), is a selective PROTAC-based STAT3 degrader with a Ki of 5.5 nM. SD-91 displays >300-fold selectivity over other STAT family protein members. SD-91 potently induces degradation of STAT3 protein in cells. SD-91 has anticancer effects, such as myeloid leukemia, lymphoma (Pink: ligand for target protein (HY-150895); Black: linker; Blue: E3 ligase ligand; E3 ligase ligand+linker: HY-176506)[1][2].

IC50 & Target[2]

STAT3

5.5 nM (Ki)

STAT3

28 nM (Kd)

Cellular Effect
Cell Line Type Value Description References
SU-DHL-1 IC50
2.6 μM
Compound: SD-91; 2
Antiproliferative activity against human SU-DHL-1 cells assessed as cell growth inhibition incubated for 4 days by CellTiter-Glo asssay
Antiproliferative activity against human SU-DHL-1 cells assessed as cell growth inhibition incubated for 4 days by CellTiter-Glo asssay
[PMID: 34141084]
In Vitro

SD-91 (Compound 92) (0.2 μM, 1 μM, 30 nM, 100 nM, 300 nM; 3 h) decreased the level of total STAT3 protein in acute leukemia Molm-16 cells[1].
In the BLI assays, SD-91 binds to STAT3 with a Kd value of 28 nM, while it displays a very weak affinity (Kd >10 μM) to all other STAT proteins (STAT1, STAT2, STAT4, STAT5A, STAT5B, and STAT6)[2].
In the MOLM-16 acute leukemia, SU-DHL-1, and SUP-M2 lymphoma cell lines, SD-91 has IC50 values of 0.17, 2.6, and 0.46 μM, respectively[2].
SD-91 (1-10 μM; 4 h) effectively reduce the levels of STAT3 protein in a dose-dependent manner, with DC50 values of 0.38 μM, 0.061μM, and 2.5 μM for MOLM-16, SU-DHL-1, and SUP-M2 cells, respectively[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SD-91 Related Antibodies

Western Blot Analysis[1]

Cell Line: Acute leukemia Molm-16 cells
Concentration: 0.2 μM, 1 μM; 30 nM, 100 nM, 300 nM
Incubation Time: 3 h
Result: Degraded the level of total STAT3 protein in acute leukemia Molm-16 cells.
In Vivo

SD-91 (Compound 92) (i.v.; 50 mg/kg; 6 h, 24 h, 48 h) decreased the level of total STAT3 protein and phosphorylated STAT3 (Y705) protein in acute leukemia Molm-16 tumors and SU-DHL-1 tumors in mice[1].
SD-91 (i.v.; 25, 50 mg/kg; qw) shows antitumor activity against Molm-16 xenograft tumors in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice[1]
Dosage: 25, 50 mg/kg
Administration: i.v.; qw
Result: Showed antitumor activity in Molm-16 and SU-DHL-1 xenograft mice.
분자량

1136.15

화학식

C59H62N9O13P
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1C[C@@H](C(N2[C@@](CC[C@H]2C(N[C@@H](CCC(N)=O)C(NC(C3=CC=CC=C3)C4=CC=CC=C4)=O)=O)([H])CC1)=O)NC(C5=CC6=CC(C(P(O)(O)=O)=O)=CC=C6N5)=O)CCCCCC#CC7=C8C(C(N(C9C(NC(CC9)=O)=O)C8)=O)=CC=C7
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
용액&용해도
In Vitro: 

DMSO : 100 mg/mL (88.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8802 mL 4.4008 mL 8.8017 mL
5 mM 0.1760 mL 0.8802 mL 1.7603 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8802 mL 4.4008 mL 8.8017 mL 22.0041 mL
5 mM 0.1760 mL 0.8802 mL 1.7603 mL 4.4008 mL
10 mM 0.0880 mL 0.4401 mL 0.8802 mL 2.2004 mL
15 mM 0.0587 mL 0.2934 mL 0.5868 mL 1.4669 mL
20 mM 0.0440 mL 0.2200 mL 0.4401 mL 1.1002 mL
25 mM 0.0352 mL 0.1760 mL 0.3521 mL 0.8802 mL
30 mM 0.0293 mL 0.1467 mL 0.2934 mL 0.7335 mL
40 mM 0.0220 mL 0.1100 mL 0.2200 mL 0.5501 mL
50 mM 0.0176 mL 0.0880 mL 0.1760 mL 0.4401 mL
60 mM 0.0147 mL 0.0733 mL 0.1467 mL 0.3667 mL
80 mM 0.0110 mL 0.0550 mL 0.1100 mL 0.2751 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

SD-91 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SD-912497583-03-4STAT3 degrader-2SD91SD 91PROTACsSTATPROTACSTAT3cancerInhibitorinhibitorinhibit

최근 본 상품:

온라인 문의

Your information is safe with us. * Required Fields.

상품명

  

Requested Quantity *

고객명 *

 

호칭

메일주소 *

 

전화번호 *

Department

 

회사명 *

City

도

Country or Region *

      

비고

대량구매 문의

Inquiry Information

상품명:
SD-91
Cat. No.:
HY-150251
수량:
MCE Japan Authorized Agent:

고객리뷰

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

상품명

  

Lot #

고객명 *

 

메일주소 *

전화번호

 

Department *

회사명 *

 

Country or Region *

비고

SAFETY DATA SHEET (SDS)

English - EN (252 KB) Français - FR (252 KB) Deutsch - DE (252 KB) Norwegian - NO (252 KB) Español - ES (252 KB) Swedish - SV (252 KB) Italian - IT (252 KB) Korean - KR (252 KB) Portuguese - PT (252 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.