2. Anti-infection
  3. Bacterial Antibiotic
  4. Temafloxacin

Temafloxacin  (Synonyms: TMFX; TA-167 free acid; A-62254 free acid)

Cat. No.: HY-16487 Pureza: 99.24%
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Temafloxacin (TMFX) is an orally active quinolone broad-spectrum antibacterial agent. Temafloxacin is well tolerated in lower respiratory and genitourinary tract infections.

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Temafloxacin

Temafloxacin Estructura química

No. CAS : 108319-06-8

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5 mg En stock
10 mg En stock
25 mg En stock
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100 mg   Obtener un presupuesto  

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Other Forms of Temafloxacin:

Temafloxacin Related Antibodies

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Descripciòn

Temafloxacin (TMFX) is an orally active quinolone broad-spectrum antibacterial agent. Temafloxacin is well tolerated in lower respiratory and genitourinary tract infections[1][2].

IC50 & Target

Quinolone

 

In Vitro

Temafloxacin (0-64 µg/mL; 18-24 h) shows good antibacterial activity for gram-positive/negative bacteria, with MIC ranges of <0.004-0.5, 0.5-2 and 0.06-0.25 µg/mL for E. coli, P. aeruginosa, and S. aureus, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Temafloxacin Related Antibodies

Cell Viability Assay[1]

Cell Line: E. coli (16 strains), P. aeruginosa (13 strains), and S. aureus (17 strains).
Concentration: 0-64 µg/mL
Incubation Time: 18-24 h
Result: Inhibited E. coli (16 strains), P. aeruginosa, and S. aureus with MIC ranges of <0.004-0.5 (MIC 90%=0.06, =0.06), 0.5-2 (MIC 90%=1, MIC 50%=1) and 0.06-0.25 µg/mL (MIC 90%=0.125, MIC 50%=0.125). MIC 90% and 50% means MIC for 90% and 50% of the isolates (unit: µg/mL).
In Vivo

Temafloxacin (6.25, 25, 100 mg/kg; p.o.; single) shows good inhibitory activity to murine pyelonephritis[1].
Temafloxacin hydrochloride (100 mg/kg; p.o. or s.c.; single) shows rapid gastrointestinal absorption, and has excellent tissue and body fluid penetration and concentration (except for central nervous system (CNS))[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female CF-1 mice (20-25 g) (murine pyelonephritis model)[1].
Dosage: 6.25, 25, 100 mg/kg
Administration: Orally; single.
Result: Reduced the number of viable bacteria in the kidneys of mice.
Animal Model: Female CF-1 mice (20-25 g)[1].
Dosage: 100 mg/kg
Administration: Subcutaneously or orally; single.
Result: 1.19 Pharmacokinetic Parameters of Temafloxacin hydrochloride in Female CF-1 mice[1].
Cmax (µg/mL) AUC (µg/mL•h) T1/2 (h) % Urinary recovery
SC (100 mg/kg) 25.2 86.6 3.4 25.3
PO (100 mg/kg) 13.5 57.4 1.3 9.1
Peso molecular

417.38

Fòrmula

C21H18F3N3O3
No. CAS
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CN(C2=CC=C(F)C=C2F)C3=C(C=C(F)C(N4CC(C)NCC4)=C3)C1=O)O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvente y solubilidad
In Vitro: 

DMSO : < 1 mg/mL (insoluble or slightly soluble)

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 0.5 mg/mL (1.20 mM); Clear solution

    This protocol yields a clear solution of ≥ 0.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (5.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación
Referencias
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Temafloxacin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Temafloxacin108319-06-8TMFXTA-167A-62254TA167TA 167A62254A 62254BacterialAntibioticE. coliP. aeruginosaS. aureusmurine pyelonephritisgram-positivegram-negativeanaerobicInhibitorinhibitorinhibit

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Temafloxacin
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