Temafloxacin hydrochloride
Temafloxacin (TMFX) hydrochloride is an orally active quinolone broad-spectrum antibacterial agent. Temafloxacin hydrochloride is well tolerated in lower respiratory and genitourinary tract infections.
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- CAS No.: 105784-61-0
- Formule: C21H19ClF3N3O3
- Masse moléculaire:453.84
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
IC50 & Target
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Quinolone |
In Vitro
Temafloxacin hydrochloride (0-64 µg/mL; 18-24 h) shows good antibacterial activity for gram-positive/negative bacteria, with MIC ranges of <0.004-0.5, 0.5-2 and 0.06-0.25 µg/mL for E. coli, P. aeruginosa, and S. aureus, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:E. coli (16 strains), P. aeruginosa (13 strains), and S. aureus (17 strains)
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Concentration:0-64 µg/mL
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Incubation Time:18-24 h
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Result:Inhibited E. coli (16 strains), P. aeruginosa, and S. aureus with MIC ranges of <0.004-0.5 (MIC 90%=0.06, =0.06), 0.5-2 (MIC 90%=1, MIC 50%=1) and 0.06-0.25 µg/mL (MIC 90%=0.125, MIC 50%=0.125). MIC 90% and 50% means MIC for 90% and 50% of the isolates (unit: µg/mL).
In Vivo
Temafloxacin hydrochloride (100 mg/kg; p.o. or s.c.; single) shows rapid gastrointestinal absorption, and has excellent tissue and body fluid penetration and concentration (except for central nervous system (CNS))[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female CF-1 mice (20-25 g) (murine pyelonephritis model)[1].
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Dosage:6.25, 25, 100 mg/kg
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Administration:Orally; single.
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Result:Reduced the number of viable bacteria in the kidneys of mice.
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Animal Model:Female CF-1 mice (20-25 g)[1].
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Dosage:100 mg/kg
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Administration:Subcutaneously or orally; single.
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Result:
1.19 Pharmacokinetic Parameters of Temafloxacin hydrochloride in Female CF-1 mice[1].
Cmax (µg/mL) AUC (µg/mL•h) T1/2 (h) % Urinary recovery SC (100 mg/kg) 25.2 86.6 3.4 25.3 PO (100 mg/kg) 13.5 57.4 1.3 9.1
Chemical Information
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CAS No. 105784-61-0
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Masse moléculaire 453.84
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Formule C21H19ClF3N3O3
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SMILES
O=C(C1=CN(C2=CC=C(F)C=C2F)C3=C(C=C(F)C(N4CC(C)NCC4)=C3)C1=O)O.Cl
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Synonyms
TMFX hydrochloride; TA-167; A-62254
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Hardy DJ, et al. Comparative antibacterial activities of temafloxacin hydrochloride (A-62254) and two reference fluoroquinolones. Antimicrob Agents Chemother. 1987 Nov;31(11):1768-74. [Content Brief]
[2]. Pankey GA. Temafloxacin: an overview. Am J Med. 1991 Dec 30;91(6A):166S-172S. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Temafloxacin hydrochloride Related Classifications
HY-113595 Related Classifications
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