Terazosin hydrochloride

Name: Terazosin hydrochloride
Brand: MedChemExpress
SKU: HY-B0371F
Rating: 5.0 (7 reviews)

Cat. No.: HY-B0371F Pureza: 99.90%: Ficha de datos
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Terazosin hydrochloride is a quinazoline derivative and a competitive and orally active α1-adrenoceptor antagonist. Terazosin hydrochloride works by relaxing blood vessels and the opening of the bladder. Terazosin hydrochloride has the potential for benign prostatic hyperplasia (BPH) and high blood pressure treatment.

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Terazosin hydrochloride Estructura química

No. CAS : 63074-08-8

Tamaño	Stock	Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
200 mg	Obtener un presupuesto
500 mg	Obtener un presupuesto

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Revisión del cliente

Based on 7 publication(s) in Google Scholar

Other Forms of Terazosin hydrochloride:

(R)-Terazosin In-stock
(S)-Terazosin In-stock
Terazosin In-stock
Terazosin hydrochloride dihydrate In-stock
Terazosin hydrochloride (Standard) Obtener un presupuesto

7 Publications Citing Use of MCE Terazosin hydrochloride

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas Adrenergic Receptor:

Ver todas las isoformas

α adrenergic receptor β adrenergic receptor

Actividad biológica
Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn

IC₅₀ & Target

α adrenergic receptor

In Vitro

Terazosin does not discriminate cloned α1-adrenoceptor subtypes transiently expressed in COS cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Terazosin can be used to promote stone discharge in treatment of ureteral stones. Terazosin is reportedly safe and effective in treatment of distal ureteral stones, especially stones >5 mm^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

423.89

Fòrmula

C₁₉H₂₆ClN₅O₄

No. CAS

63074-08-8

Appearance

Solid

Color

White to off-white

SMILES

O=C(N1CCN(C2=NC(N)=C3C=C(OC)C(OC)=CC3=N2)CC1)C4OCCC4.[H]Cl

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvente y solubilidad

In Vitro:

DMSO : 16.67 mg/mL (39.33 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3591 mL	11.7955 mL	23.5910 mL
5 mM	0.4718 mL	2.3591 mL	4.7182 mL
10 mM	0.2359 mL	1.1796 mL	2.3591 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Pureza y Documentación

Purity: 99.90%

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Ficha de datos (274 KB) SDS (393 KB)

COA (250 KB) HNMR (288 KB) LCMS (102 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Michel MC, et al. Drugs for treatment of benign prostatic hyperplasia: affinity comparison at cloned alpha 1-adrenoceptor subtypes and in human prostate. J Auton Pharmacol. 1996 Feb;16(1):21-8. [Content Brief]

[2]. Vincent J, et al. Pharmacological tolerance to alpha 1-adrenergic receptor antagonism mediated by terazosin in humans. J Clin Invest. 1992 Nov;90(5):1763-8. [Content Brief]

[3]. Ju M, et al. Efficacy of combination terazosin and nifedipine therapy in postoperative treatment of distal ureteral stones after transurethral ureteroscopic lithotripsy. J Int Med Res. 2020 Apr;48(4):300060520904851. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.3591 mL	11.7955 mL	23.5910 mL	58.9776 mL
	5 mM	0.4718 mL	2.3591 mL	4.7182 mL	11.7955 mL
	10 mM	0.2359 mL	1.1796 mL	2.3591 mL	5.8978 mL
	15 mM	0.1573 mL	0.7864 mL	1.5727 mL	3.9318 mL
	20 mM	0.1180 mL	0.5898 mL	1.1796 mL	2.9489 mL
	25 mM	0.0944 mL	0.4718 mL	0.9436 mL	2.3591 mL
	30 mM	0.0786 mL	0.3932 mL	0.7864 mL	1.9659 mL