2. GPCR/G Protein Metabolic Enzyme/Protease
  3. P2Y Receptor Endogenous Metabolite
  4. Uridine 5'-diphosphate

Uridine 5'-diphosphate (UDP) is a P2Y6 receptor agonist with an EC50 of 0.013 μM for human P2Y6 receptor.

It is advisable to consider the salt form (Uridine-5'-diphosphate disodium salt) that retains the same biological activity.

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Uridine 5'-diphosphate

Uridine 5'-diphosphate 構造式

CAS 番号 : 58-98-0

容量 在庫状況
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Other 在庫あり Forms of Uridine 5'-diphosphate:

Uridine 5'-diphosphate 関連抗体

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P2Y Receptor アイソフォーム固有の製品をすべて表示:

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P2Y1 Receptor P2Y2 Receptor P2Y6 Receptor P2Y11 Receptor P2Y12 Receptor P2Y13 Receptor P2Y14 Receptor

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Human Endogenous Metabolite Microbial Metabolite

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製品説明

Uridine 5'-diphosphate (UDP) is a P2Y6 receptor agonist with an EC50 of 0.013 μM for human P2Y6 receptor[1][2].

IC50 & Target[1]

P2Y6 Receptor

0.013 μM (EC50)

Human Endogenous Metabolite

 

Cellular Effect
Cell Line Type Value Description References
COS-7 EC50
160 μM
Compound: 2, UDP
Agonist activity at recombinant human P2Y14 receptor expressed in African green monkey COS7 cells co-transfected with Galphaqi assessed as stimulation of phospholipase Cbeta
Agonist activity at recombinant human P2Y14 receptor expressed in African green monkey COS7 cells co-transfected with Galphaqi assessed as stimulation of phospholipase Cbeta
[PMID: 25868749]
HEK293 EC50
0.16 μM
Compound: 1, UDP
Agonist activity at human recombinant P2Y14 receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation proximity assay
Agonist activity at human recombinant P2Y14 receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation proximity assay
[PMID: 20446735]
HEK293 EC50
160 nM
Compound: 3
Agonist activity at human P2Y14 receptor expressed in HEK293 cells coexpressing phospholipase C-activating Gi protein cells assessed as inhibition of forskolin induced [3H]cAMP production
Agonist activity at human P2Y14 receptor expressed in HEK293 cells coexpressing phospholipase C-activating Gi protein cells assessed as inhibition of forskolin induced [3H]cAMP production
[PMID: 19902968]
体外実験

Uridine 5'-diphosphate stimulates phospholipase C (PLC) in 1321N1 astrocytoma cells (EC50 = 86 nM)[1].
Uridine 5'-diphosphate act as a carrier of activated sugars, such as glucose[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Uridine 5'-diphosphate 関連抗体
分子量

404.16

分子式

C9H14N2O12P2
CAS 番号
SMILES

O=C(C=CN1[C@H]2[C@H](O)[C@H](O)[C@@H](COP(OP(O)(O)=O)(O)=O)O2)NC1=O
Structure Classification
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
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Uridine 5'-diphosphate Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Uridine 5'-diphosphate58-98-0UDPP2Y ReceptorEndogenous MetaboliteInhibitorinhibitorinhibit

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製品名:
Uridine 5'-diphosphate
製品番号:
HY-113359
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