2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. Veratridine

Veratridine  (Synonyms: 3-Veratroylveracevine)

製品番号: HY-N6691 純度: 99.42%
COA 取扱説明書 Technical Support

Veratridine (3-Veratroylveracevine) is a plant neurotoxin, a voltage-gated sodium channels (VGSCs) agonist. Veratridine inhibits the peak current of Nav1.7, with an IC50 of 18.39 µM. Veratridine regulates sodium ion channels mainly by activating sodium ion channels, preventing channel inactivation and increasing sodium ion flow.

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CAS 番号 : 71-62-5

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 178 在庫あり
Solution
10 mM * 1 mL in DMSO USD 178 在庫あり
Solid
5 mg $120 在庫あり
10 mg $190 在庫あり
25 mg $380 在庫あり
50 mg $570 在庫あり
100 mg   お問い合わせ  
200 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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カスタマーレビュー

Based on 4 publication(s) in Google Scholar

Other Forms of Veratridine:

Veratridine 関連抗体

Top Publications Citing Use of Products

    Veratridine purchased from MedChemExpress. Usage Cited in: Sci Rep. 2025 Jul 16;15(1):25854.  [Abstract]

    Dose-response curve of Veratridine (24 h) against growth of SH-SY5Y cells combined with 0.1 µM OB. Cell viability was measured by CCK-8 assay and mean values of triplicates ± SD are shown.

    Veratridine purchased from MedChemExpress. Usage Cited in: Sci Rep. 2025 Jul 16;15(1):25854.  [Abstract]

    The bright field images of SH-SY5Y cells treated with DMSO, OB alone or in combination thereof with indicated concentrations of Veratridine (100 μM) for 24 h.

    Veratridine purchased from MedChemExpress. Usage Cited in: Neuropsychopharmacology. 2025 Mar;50(4):662-672.  [Abstract]

    Representative traces of the four responses profiles triggered by veratridine (30 µM): oscillatory (OS), slow decay (SD), rapid decay (RD), and intermediate decay (ID) profile.

    Veratridine purchased from MedChemExpress. Usage Cited in: Neuropsychopharmacology. 2025 Mar;50(4):662-672.  [Abstract]

    Percentage of different population of DRG neurons based on Veratridine (30 μM)-response pattern after treated with 0.1% DMSO or 20 μM SOP overnight incubation. Pie charts represent mean values in the histogram (0.1% DMSO, n = 8 slides; SOP, n = 8 slides).

    Veratridine purchased from MedChemExpress. Usage Cited in: Proteome Sci. 2023 Oct 12;21(1):17.  [Abstract]

    µ-CTX GIIIB protects the Sol8 cells from the cell injury induced by ouabain and Veratridine (veratrine, 0, 2, 4, 6, 8, and 10 µL, 24 h). The effects of ouabain and veratrine on cell survival rate of Sol8 cells was detected by CCK-8.

    Sodium Channel アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Nav1.1 Nav1.2 Nav1.3 Nav1.4 Nav1.5 Nav1.6 Nav1.7 Nav1.8 Nav1.9

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    Veratridine (3-Veratroylveracevine) is a plant neurotoxin, a voltage-gated sodium channels (VGSCs) agonist. Veratridine inhibits the peak current of Nav1.7, with an IC50 of 18.39 µM. Veratridine regulates sodium ion channels mainly by activating sodium ion channels, preventing channel inactivation and increasing sodium ion flow[1][2].

    IC50 & Target[1]

    Nav1.7

    18.39 μM (IC50)

    体外実験

    Veratridine (0.25 mM and 1 mM; 24 h) treatment results in all cells death[2].
    Veratridine (0.001-100 μM) produces tetrodotoxin-sensitive responses[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Veratridine 関連抗体

    Cell Cytotoxicity Assay[2]

    Cell Line: Neuro-2a cells
    Concentration: 0.25 mM and 1 mM
    Incubation Time: 24 hours
    Result: Caused around 100% cell mortality (0% cell viability).

    Cell Viability Assay[3]

    Cell Line: Cultured mouse DRG neurons
    Concentration: 0.001, 0.1, 1, 10, 30, and 100 μM
    Incubation Time:
    Result: Increased responding neurons number from a threshold of 1 μM in a concentration-dependent manner.
    分子量

    673.79

    分子式

    C36H51NO11
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    C[C@@]12[C@]34[C@](CC[C@]1([H])[C@@](O)([C@@H](OC(C5=CC(OC)=C(OC)C=C5)=O)CC2)O4)([H])[C@@]6(O)[C@](O)([C@@]7([H])[C@@](O)([C@](O)([C@@]8([H])N(C[C@@H](C)CC8)C7)C)[C@@H](O)C6)C3
    Structure Classification
    Initial Source
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件
    Powder -20°C 3 years
    In solvent -80°C 6 months
      -20°C 1 month
    溶剤 & 溶解度
    体外: 

    DMSO : 100 mg/mL (148.41 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.4841 mL 7.4207 mL 14.8414 mL
    5 mM 0.2968 mL 1.4841 mL 2.9683 mL
    10 mM 0.1484 mL 0.7421 mL 1.4841 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
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    Volume
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

    V1

    =
    濃度 （終了）

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    体積 （終了）

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    体内:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (3.71 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (3.71 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    純度とドキュメンテーション

    純度: 99.42%

    COA (259 KB) HNMR (295 KB) LCMS (95 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.4841 mL 7.4207 mL 14.8414 mL 37.1035 mL
    5 mM 0.2968 mL 1.4841 mL 2.9683 mL 7.4207 mL
    10 mM 0.1484 mL 0.7421 mL 1.4841 mL 3.7104 mL
    15 mM 0.0989 mL 0.4947 mL 0.9894 mL 2.4736 mL
    20 mM 0.0742 mL 0.3710 mL 0.7421 mL 1.8552 mL
    25 mM 0.0594 mL 0.2968 mL 0.5937 mL 1.4841 mL
    30 mM 0.0495 mL 0.2474 mL 0.4947 mL 1.2368 mL
    40 mM 0.0371 mL 0.1855 mL 0.3710 mL 0.9276 mL
    50 mM 0.0297 mL 0.1484 mL 0.2968 mL 0.7421 mL
    60 mM 0.0247 mL 0.1237 mL 0.2474 mL 0.6184 mL
    80 mM 0.0186 mL 0.0928 mL 0.1855 mL 0.4638 mL
    100 mM 0.0148 mL 0.0742 mL 0.1484 mL 0.3710 mL
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    Veratridine Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Veratridine71-62-53-VeratroylveracevineSodium ChannelNa channelsNa+ channelsLiliaceaeNav1.7voltage-gated sodium channelsNeuro-2aDRG neuronsInhibitorinhibitorinhibit

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    製品名:
    Veratridine
    製品番号:
    HY-N6691
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