3,4-Dicaffeoylquinic acid (Synonyms: 3,4-Di-O-caffeoylquinic acid; Isochlorogenic acid B)

Name: 3,4-Dicaffeoylquinic acid
Brand: MedChemExpress
SKU: HY-N0057
Rating: 5.0 (8 reviews)

Cat. No.: HY-N0057 Purity: 98.15%: Data Sheet
COA

SDS
Handling Instructions
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Technical Support

3,4-Dicaffeoylquinic acid (3,4-Di-O-caffeoylquinic acid), naturally isolated from Laggera alata, has antioxidative, DNA protective, neuroprotective and hepatoprotective properties. 3,4-Dicaffeoylquinic acid exerts apoptosis-mediated cytotoxicity and α-glucosidase inhibitory effects. 3,4-Dicaffeoylquinic acid possesses a unique mechanism of anti-influenza viral activity, that is, enhancing viral clearance by increasing TRAIL.

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3,4-Dicaffeoylquinic acid 화학구조

CAS No. : 14534-61-3

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
1 mg	해외재고보유	Estimated Time of Arrival: December 31
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

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고객리뷰

Based on 8 publication(s) in Google Scholar

Other Forms of 3,4-Dicaffeoylquinic acid:

(E)-3,4-Dicaffeoylquinic acid 견적 받기
3,4-Dicaffeoylquinic acid (Standard) 견적 받기

8 Publications Citing Use of MCE 3,4-Dicaffeoylquinic acid

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•Related Screening Libraries:

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View All Endogenous Metabolite Isoform Specific Products:

View All Isoforms

Human Endogenous Metabolite Microbial Metabolite

Biological Activity
순도&문서
References
고객리뷰

제품 설명

Cellular Effect

Cell Line	Type	Value	Description	References
Jurkat	IC₅₀	>35 92 Compound: 3	Cytotoxicity against human Jurkat T cells Cytotoxicity against human Jurkat T cells	[PMID: 15921434]
Jurkat	IC₅₀	> 35 2 Compound: 3	Cytotoxicity against human Jurkat T cells Cytotoxicity against human Jurkat T cells	[PMID: 15921434]

In Vitro

3,4-Dicaffeoylquinic acid acts as a greater primary antioxidant than its methanol extract, by having higher ferric reducing activity (EC₅₀ 2.18 μg/ml), β-carotene bleaching activity (EC₅₀ 23.85 μg/ml) and DPPH scavenging activity (EC₅₀ 68.91 μg/ml). 3,4-Dicaffeoylquinic acid exhibits a remarkable dose-dependent inhibitory effect on NCI-H23 (human lung adenocarcinoma) cell lines (EC₅₀ 3.26 μg/ml) and is found to be apoptotic in nature based on a clear indication of DNA fragmentation. 3,4-Dicaffeoylquinic acid also displays a concentration-dependent α-glucosidase inhibition with EC₅₀ 241.80 μg/ml^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

516.45

화학식

C₂₅H₂₄O₁₂

CAS No.

14534-61-3

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C([C@@]1(O)C[C@@H](OC(/C=C/C2=CC=C(O)C(O)=C2)=O)[C@H](OC(/C=C/C3=CC=C(O)C(O)=C3)=O)[C@H](O)C1)O

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Endogenous metabolite

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : 50 mg/mL (96.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9363 mL	9.6815 mL	19.3630 mL
5 mM	0.3873 mL	1.9363 mL	3.8726 mL
10 mM	0.1936 mL	0.9681 mL	1.9363 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

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In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 98.15%

Select Batch:

Data Sheet (278 KB) SDS (393 KB)

COA (254 KB) HNMR (312 KB) LCMS (105 KB)

Handling Instructions (2659 KB)

References

[1]. Takemura T, et al. 3,4-Dicaffeoylquinic Acid, a Major Constituent of Brazilian Propolis, Increases TRAIL Expression and Extends the Lifetimes of Mice Infected with the Influenza A Virus. Evid Based Complement Alternat Med. 2012;2012:946867. [Content Brief]

[2]. Liu X, et al. Protective effect of isochlorogenic acid B on liver fibrosis in non-alcoholic steatohepatitis of mice. Basic Clin Pharmacol Toxicol. 2019;124(2):144-153. [Content Brief]

[3]. Ooi KL, et al. Cytotoxic, apoptotic and anti-α-glucosidase activities of 3,4-di-O-caffeoyl quinic acid, an antioxidant isolated from the polyphenolic-rich extract of Elephantopus mollis Kunth. J Ethnopharmacol. 2011;135(3):685-695. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9363 mL	9.6815 mL	19.3630 mL	48.4074 mL
	5 mM	0.3873 mL	1.9363 mL	3.8726 mL	9.6815 mL
	10 mM	0.1936 mL	0.9681 mL	1.9363 mL	4.8407 mL
	15 mM	0.1291 mL	0.6454 mL	1.2909 mL	3.2272 mL
	20 mM	0.0968 mL	0.4841 mL	0.9681 mL	2.4204 mL
	25 mM	0.0775 mL	0.3873 mL	0.7745 mL	1.9363 mL
	30 mM	0.0645 mL	0.3227 mL	0.6454 mL	1.6136 mL
	40 mM	0.0484 mL	0.2420 mL	0.4841 mL	1.2102 mL
	50 mM	0.0387 mL	0.1936 mL	0.3873 mL	0.9681 mL
	60 mM	0.0323 mL	0.1614 mL	0.3227 mL	0.8068 mL
	80 mM	0.0242 mL	0.1210 mL	0.2420 mL	0.6051 mL

3,4-Dicaffeoylquinic acid Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3,4-Dicaffeoylquinic acid14534-61-33,4-Di-O-caffeoylquinic acid Isochlorogenic acid BGlycosidaseInfluenza VirusApoptosisEndogenous MetabolitenaturallyantioxidativeDNAprotectiveneuroprotectivehepatoprotectiveInhibitorinhibitorinhibit

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3,4-Dicaffeoylquinic acid (Synonyms: 3,4-Di-O-caffeoylquinic acid; Isochlorogenic acid B)

고객리뷰

Other Forms of 3,4-Dicaffeoylquinic acid:

3,4-Dicaffeoylquinic acid Related Antibodies

8 Publications Citing Use of MCE 3,4-Dicaffeoylquinic acid

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Endogenous Metabolite Isoform Specific Products:

Biological Activity

순도&문서

References

고객리뷰

3,4-Dicaffeoylquinic acid Related Antibodies

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

3,4-Dicaffeoylquinic acid Related Classifications

Keywords:

최근 본 상품:

고객리뷰

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report