2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation
  3. Endogenous Metabolite Reactive Oxygen Species (ROS)
  4. 3-Indolepropionic acid

3-Indolepropionic acid  (Synonyms: Indole-3-propionic acid; 3-IPA)

Cat. No.: HY-W015229 Purity: 99.78%
COA
SDS
Handling Instructions Technical Support

3-Indolepropionic acid is shown to be a powerful antioxidant and has potential in the treatment for Alzheimer’s disease.

For research use only. We do not sell to patients.

CAS No. : 830-96-6

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
5 g In-stock
10 g In-stock
50 g   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 10 publication(s) in Google Scholar

Other Forms of 3-Indolepropionic acid:

3-Indolepropionic acid Related Antibodies

Top Publications Citing Use of Products

    3-Indolepropionic acid purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Mar 19;16(1):2651.  [Abstract]

    Mice were treated with 40 mg/kg 3-Indolepropionic acid by gavage for a fortnight. J Ejection fraction (EF) was measured. K Relative mRNA levels of Bnp were determined. L Plasma biomarker assessments revealed levels of cardiac troponin T (cTnT).

    3-Indolepropionic acid purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Mar 19;16(1):2651.  [Abstract]

    Mice were treated with 40 mg/kg 3-indolepropionic acid by gavage for a fortnight. Representative western blots of AhR and CYP1A1 after deficiency of IPA receptor AhR were shown.

    3-Indolepropionic acid purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Mar 19;16(1):2651.  [Abstract]

    Mice were treated with 40 mg/kg 3-indolepropionic acid by gavage for a fortnight. Relative mRNA levels of Bnp (n = 6) were measured.

    3-Indolepropionic acid purchased from MedChemExpress. Usage Cited in: EBioMedicine. 2025 Dec:122:106037.  [Abstract]

    3-Indolepropionic acid was administered to mice by oral gavage at a dosage of 50 mg/kg, and representative images of H&E-stained liver sections with NAS scores were obtained.

    3-Indolepropionic acid purchased from MedChemExpress. Usage Cited in: EBioMedicine. 2025 Dec:122:106037.  [Abstract]

    3-Indolepropionic acid was administered to mice by oral gavage at a dosage of 50 mg/kg, and relative Dnm1l, Fis1, Mfn2, and Opa1 mRNA expression in the liver was measured.

    View All Endogenous Metabolite Isoform Specific Products:

    View All Isoforms
    Human Endogenous Metabolite Microbial Metabolite

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    3-Indolepropionic acid is shown to be a powerful antioxidant and has potential in the treatment for Alzheimer’s disease.

    IC50 & Target

    Microbial Metabolite

     

    Human Endogenous Metabolite

     

    Cellular Effect
    Cell Line Type Value Description References
    HepG2 CC50
    > 1000 μM
    Compound: IPA
    Cytotoxicity against human HepG2 cells after 24 hrs by CellTiter 96 AQueous One Solution Cell Proliferation assay
    Cytotoxicity against human HepG2 cells after 24 hrs by CellTiter 96 AQueous One Solution Cell Proliferation assay
    		[PMID: 31627992]
    Sf9 IC50
    0.14 mM
    Compound: 3-indolepropionicacid
    Inhibition of human recombinant KAT1 expressed in Sf9 cells
    Inhibition of human recombinant KAT1 expressed in Sf9 cells
    		[PMID: 19338303]
    In Vitro

    3-Indolepropionic acid is shown to be a powerful antioxidant and has potential in the treatment for Alzheimer’s disease[1]. 3-Indolepropionic acid is a more potent scavenger of hydroxyl radicals than melatonin. Similar to melatonin but unlike other antioxidants, 3-Indolepropionic acid scavenges radicals without subsequently generating reactive and pro-oxidant intermediate compounds[2]. It is also suggested that indolepropionic acid, a gut microbiota-produced metabolite, is a potential biomarker for the development of type 2 diabetes (T2D) that may mediate its protective effect by preservation of β-cell function[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    3-Indolepropionic acid Related Antibodies
    Clinical Trial
    Molecular Weight

    189.21

    Formula

    C11H11NO2
    CAS No.
    Appearance

    Solid

    Color

    Off-white to yellow

    SMILES

    C1=CC=CC2=C1C(=C[NH]2)CCC(O)=O
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 100 mg/mL (528.51 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : 1 mg/mL (5.29 mM; ultrasonic and warming and heat to 80°C)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 5.2851 mL 26.4257 mL 52.8513 mL
    5 mM 1.0570 mL 5.2851 mL 10.5703 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (13.21 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (13.21 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  50% PEG300    50% Saline

      Solubility: 10 mg/mL (52.85 mM); Clear solution; Need ultrasonic

    • Protocol 2

      Add each solvent one by one:  15% Cremophor EL    85% Saline

      Solubility: 10 mg/mL (52.85 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation

    Purity: 99.89%

    SDS (393 KB)

    COA (251 KB) HNMR (133 KB) RP-HPLC (268 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 5.2851 mL 26.4257 mL 52.8513 mL 132.1283 mL
    5 mM 1.0570 mL 5.2851 mL 10.5703 mL 26.4257 mL
    DMSO 10 mM 0.5285 mL 2.6426 mL 5.2851 mL 13.2128 mL
    15 mM 0.3523 mL 1.7617 mL 3.5234 mL 8.8086 mL
    20 mM 0.2643 mL 1.3213 mL 2.6426 mL 6.6064 mL
    25 mM 0.2114 mL 1.0570 mL 2.1141 mL 5.2851 mL
    30 mM 0.1762 mL 0.8809 mL 1.7617 mL 4.4043 mL
    40 mM 0.1321 mL 0.6606 mL 1.3213 mL 3.3032 mL
    50 mM 0.1057 mL 0.5285 mL 1.0570 mL 2.6426 mL
    60 mM 0.0881 mL 0.4404 mL 0.8809 mL 2.2021 mL
    80 mM 0.0661 mL 0.3303 mL 0.6606 mL 1.6516 mL
    100 mM 0.0529 mL 0.2643 mL 0.5285 mL 1.3213 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    3-Indolepropionic acid Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    3-Indolepropionic acid830-96-6Indole-3-propionic acid 3-IPAEndogenous MetaboliteReactive Oxygen Species (ROS)Inhibitorinhibitorinhibit

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Requested Quantity *

    Applicant Name *

    		 

    Salutation

    Email Address *

    		 

    Phone Number *

    Department

    		 

    Organization Name *

    City

    State

    Country or Region *

    		      

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    3-Indolepropionic acid
    Cat. No.:
    HY-W015229
    Quantity:
    MCE Japan Authorized Agent:

    Customer Review

    Thank You for Your Feedback!

    Request for HNMR Report

    Please fill out this form to request the QC report. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Lot #

    Applicant Name *

    		 

    Email Address *

    Phone Number

    		 

    Department *

    Organization Name *

    		 

    Country or Region *

    Remarks

    SAFETY DATA SHEET (SDS)

    English - EN (393 KB) Français - FR (393 KB) Deutsch - DE (393 KB) Norwegian - NO (393 KB) Español - ES (393 KB) Swedish - SV (393 KB) Italian - IT (393 KB) Korean - KR (393 KB) Portuguese - PT (393 KB)

    Request for HNMR Report

    We have received your request and will respond to you as soon as possible.