1. PI3K/Akt/mTOR
  2. PI3K

Acalisib (Synonyms: GS-9820; CAL-120)

Cat. No.: HY-12644
Handling Instructions

Acalisib (GS-9820) is a potent and selective inhibitor of PI3Kδ with IC50 value of 12.7 nM.

For research use only. We do not sell to patients.
Acalisib Chemical Structure

Acalisib Chemical Structure

CAS No. : 870281-34-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO $99 In-stock
5 mg $90 In-stock
10 mg $150 In-stock
50 mg $400 In-stock
100 mg $580 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

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Description

Acalisib (GS-9820) is a potent and selective inhibitor of PI3Kδ with IC50 value of 12.7 nM. IC50 value: 12.7 nM [1] Target: PI3Kδ in vitro: GS-9820 is more selective for PI3Kδ relative to other PI3K class I enzymes (IC50: PI3Kα, 5,441 nM; PI3Kβ, 3,377 nM; PI3Kγ, 1,389 nM; and PI3Kδ, 12.7 nM) . GS-9820 suppresses Fc?RI PI3Kδ-mediated CD63 expression with an EC50 of 14 nM, and fMLP PI3Kγ-mediated CD63 expression with an EC50 of 2,065 nM. GS-9820 shows selectivity for PI3Kδ over the other class I PI3K isoforms and virtually no binding to a panel of other kinases. [1]

Clinical Trial
NCT Number Sponsor Condition Start Date Phase
NCT01705847 Gilead Sciences Lymphoid Malignancies November 2012 Phase 1
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References
Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 2.4913 mL 12.4564 mL 24.9128 mL
5 mM 0.4983 mL 2.4913 mL 4.9826 mL
10 mM 0.2491 mL 1.2456 mL 2.4913 mL
References
Molecular Weight

401.4

Formula

C₂₁H₁₆FN₇O

CAS No.

870281-34-8

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 29 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Acalisib
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