2. MAPK/ERK Pathway
  3. Raf
  4. BRAF inhibitor

BRAF inhibitor (Compound P-0850) is a B-Raf inhibitor with anti-tumor activity.

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BRAF inhibitor

BRAF inhibitor Estructura química

No. CAS : 918505-61-0

Tamaño Precio Stock Cantidad
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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 En stock
Solution
10 mM * 1 mL in DMSO En stock
Solid
5 mg En stock
10 mg En stock
50 mg En stock
100 mg   Obtener un presupuesto  
200 mg   Obtener un presupuesto  

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Revisión del cliente

Based on 1 publication(s) in Google Scholar

Other Forms of BRAF inhibitor:

BRAF inhibitor Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE BRAF inhibitor

Ver todos los productos específicos de isoformas Raf:

Ver todas las isoformas
B-Raf C-Raf Raf

  • Actividad biológica

  • Pureza y Documentación

  • Referencias

  • Revisión del cliente

Descripciòn

BRAF inhibitor (Compound P-0850) is a B-Raf inhibitor with anti-tumor activity[1][2].

IC50 & Target[1]

B-Raf

 

In Vitro

BRAF inhibitor does not affect the phosphorylation of SQSTM1 (T269/S272) and the aggresome formation upon proteasome inhibition[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BRAF inhibitor Related Antibodies
Peso molecular

456.47

Fòrmula

C22H18F2N4O3S
No. CAS
Appearance

Solid

Color

White to off-white

SMILES

CC(C)S(=O)(NC1=CC=C(C(C(C2=CNC3=NC=C(C=C32)C4=CC=CN=C4)=O)=C1F)F)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvente y solubilidad
In Vitro: 

DMSO : 50 mg/mL (109.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1907 mL 10.9536 mL 21.9072 mL
5 mM 0.4381 mL 2.1907 mL 4.3814 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (5.48 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (5.48 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación

Purity: 98.07%

SDS (393 KB)

COA (251 KB) LCMS (97 KB)

Instrucciones de manejo (2659 KB)
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1907 mL 10.9536 mL 21.9072 mL 54.7681 mL
5 mM 0.4381 mL 2.1907 mL 4.3814 mL 10.9536 mL
10 mM 0.2191 mL 1.0954 mL 2.1907 mL 5.4768 mL
15 mM 0.1460 mL 0.7302 mL 1.4605 mL 3.6512 mL
20 mM 0.1095 mL 0.5477 mL 1.0954 mL 2.7384 mL
25 mM 0.0876 mL 0.4381 mL 0.8763 mL 2.1907 mL
30 mM 0.0730 mL 0.3651 mL 0.7302 mL 1.8256 mL
40 mM 0.0548 mL 0.2738 mL 0.5477 mL 1.3692 mL
50 mM 0.0438 mL 0.2191 mL 0.4381 mL 1.0954 mL
60 mM 0.0365 mL 0.1826 mL 0.3651 mL 0.9128 mL
80 mM 0.0274 mL 0.1369 mL 0.2738 mL 0.6846 mL
100 mM 0.0219 mL 0.1095 mL 0.2191 mL 0.5477 mL
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BRAF inhibitor Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BRAF inhibitor918505-61-0RafRaf kinasesanti-tumor activityInhibitorinhibitorinhibit

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Nombre del producto:
BRAF inhibitor
Cat. No.:
HY-10247
Cantidad:
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