2. Anti-infection
  3. Antibiotic Bacterial
  4. Dihydrostreptomycin sulfate

Dihydrostreptomycin sulfate  (Synonyms: DHSM sulfate)

Art. -Nr.: HY-B1241 Reinheit: 99.68%
COA
SDS
Handling Instructions Technical Support

Dihydrostreptomycin sulfate (DHSM sulfate) is the sulfate salt form of Dihydrostreptomycin (HY-B1241A). Dihydrostreptomycin sulfate is an aminoglycoside antibiotic with antibacterial effect against Gram-negative bacteria. Dihydrostreptomycin sulfate exhibits ototoxicity that causes irreversible damage in inner ear hair cells, leading to hearing loss.

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Dihydrostreptomycin sulfate

Dihydrostreptomycin sulfate Chemische Struktur

CAS. Nr. : 5490-27-7

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 Auf Lager
Solution
10 mM * 1 mL in Water Auf Lager
Solid
500 mg Auf Lager
1 g Auf Lager
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Other Forms of Dihydrostreptomycin sulfate:

Dihydrostreptomycin sulfate Related Antibodies

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Beschreibung

Dihydrostreptomycin sulfate (DHSM sulfate) is the sulfate salt form of Dihydrostreptomycin (HY-B1241A). Dihydrostreptomycin sulfate is an aminoglycoside antibiotic with antibacterial effect against Gram-negative bacteria. Dihydrostreptomycin sulfate exhibits ototoxicity that causes irreversible damage in inner ear hair cells, leading to hearing loss[1].

IC50 & Target

Aminoglycoside

 

In Vitro

Dihydrostreptomycin sulfate blocks mechanoelectric transduction channels, induces increased intracellular calcium concentrations, and leads to the obstruction of auditory signal transmission[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dihydrostreptomycin sulfate Related Antibodies
In Vivo

Dihydrostreptomycin sulfate (600 mg/kg, ip, once daily for 12 days) induces spiral ligament damage in mice, promotes the proliferation of spiral ligament cells in the mouse cochlea, and the expression of FGF receptors and connexin 43 in the spiral ligament[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mouse models[2]
Dosage: 600 mg/kg
Administration: ip, once daily for 12 days
Result: Upregulated the expression of FGF receptors and connexin 43, increased the number of BrdU-positive cells in the spiral ligament.
Molekulargewicht

730.71

Formel

C21H41N7O12 . 3/2 H2SO4
CAS. Nr.
Appearance

Solid

Color

White to off-white

SMILES

O[C@@H]1[C@@H](O)[C@@](O[C@@H]2O[C@@H](C)[C@](O)(CO)[C@H]2O[C@@]3([H])[C@@H](NC)[C@H](O)[C@@H](O)[C@H](CO)O3)([H])[C@@H](NC(N)=N)[C@H](O)[C@H]1NC(N)=N.[1.5H2SO4]
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Lösungsmittel & Löslichkeit
In Vitro: 

H2O : 250 mg/mL (342.13 mM; Need ultrasonic)

DMSO : 5.83 mg/mL (7.98 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3685 mL 6.8427 mL 13.6853 mL
5 mM 0.2737 mL 1.3685 mL 2.7371 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (136.85 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Reinheit & Dokumentation

Purity: 99.68%

SDS (557 KB)

COA (262 KB) HNMR (322 KB) LCMS (88 KB)

Handling Instructions (2659 KB)
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 1.3685 mL 6.8427 mL 13.6853 mL 34.2133 mL
5 mM 0.2737 mL 1.3685 mL 2.7371 mL 6.8427 mL
H2O 10 mM 0.1369 mL 0.6843 mL 1.3685 mL 3.4213 mL
15 mM 0.0912 mL 0.4562 mL 0.9124 mL 2.2809 mL
20 mM 0.0684 mL 0.3421 mL 0.6843 mL 1.7107 mL
25 mM 0.0547 mL 0.2737 mL 0.5474 mL 1.3685 mL
30 mM 0.0456 mL 0.2281 mL 0.4562 mL 1.1404 mL
40 mM 0.0342 mL 0.1711 mL 0.3421 mL 0.8553 mL
50 mM 0.0274 mL 0.1369 mL 0.2737 mL 0.6843 mL
60 mM 0.0228 mL 0.1140 mL 0.2281 mL 0.5702 mL
80 mM 0.0171 mL 0.0855 mL 0.1711 mL 0.4277 mL
100 mM 0.0137 mL 0.0684 mL 0.1369 mL 0.3421 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dihydrostreptomycin sulfate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dihydrostreptomycin5490-27-7DHSMAntibioticBacterialInhibitorinhibitorinhibit

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