2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation Apoptosis
  3. Endogenous Metabolite Reactive Oxygen Species (ROS) Ferroptosis
  4. L-Glutathione reduced

L-Glutathione reduced  (Synonyms: GSH; γ-L-Glutamyl-L-cysteinyl-glycine)

Cat. No.: HY-D0187 Pureté: 99.79%
COA
SDS
Instruction de manipulation Technical Support

L-Glutathione reduced (GSH; γ-L-Glutamyl-L-cysteinyl-glycine) is an endogenous antioxidant and is capable of scavenging oxygen-derived free radicals.

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Synthèse de peptides personnalisée

CAS No. : 70-18-8

Size Prix Stock Quantité
500 mg En stock
1 g En stock
5 g En stock
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50 g   Obtenir un devis  

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Based on 54 publication(s) in Google Scholar

Other Forms of L-Glutathione reduced:

L-Glutathione reduced Related Antibodies

Top Publications Citing Use of Products

54 Publications Citing Use of MCE L-Glutathione reduced

RT-PCR
Cell Proliferation/Viability Assay

    L-Glutathione reduced purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Apr 22;16(1):3777.  [Abstract]

    RT‒qPCR analyses demonstrated that the transcriptional upregulation of sHSP genes (17.4, 17.6A, 21, 23.5) in ClpD-GFP line #5 was suppressed by the ROS scavenging reagent GSH (500 µM, 2 days). HSP18.5 and the transcripts encoding two large HSPs (HSP90C and mtHSC70-1) were used as negative controls.

    L-Glutathione reduced purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Jul:84:103693.  [Abstract]

    BR-CHAC1-OE and MR-CHAC1-OE cells were treated with DMSO, AZD4547 (2.5 μM) with or without GSH (10 mM) and NAC (5 mM) for 72 h, and cell viability was measured by the CCK-8 assay.

    L-Glutathione reduced purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Aug:74:589-607.  [Abstract]

    Cell viability was measured after being pretreated with Fer-1 (2 μM), GSH (1 mM), or DFO (50 μM) for 1 h, and then treated with or without Sal (50 μM) for 24 h (n = 6).

    L-Glutathione reduced purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2021 Dec;11(12):4045-4054.

    KU-19-19 was treated with baicalin with or without glutathione (GSH) (1.5 mM) for 24 h, then cell viability was analyzed.

    L-Glutathione reduced purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2020 May 8;5(1):51.  [Abstract]

    H460 and H1299 cells were treated with erianin with or without the ROS scavenger GSH (1 mM) for 24 h, and cell viability was assayed.

    Voir tous les produits spécifiques à Isoform Endogenous Metabolite:

    Voir toutes les isoformes
    Human Endogenous Metabolite Microbial Metabolite

    • Activité biologique

    • Pureté et documentation

    • Références

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    Description

    L-Glutathione reduced (GSH; γ-L-Glutamyl-L-cysteinyl-glycine) is an endogenous antioxidant and is capable of scavenging oxygen-derived free radicals.

    IC50 & Target

    Human Endogenous Metabolite

     

    Cellular Effect
    Cell Line Type Value Description References
    KB 3-1 IC50
    >20 mM
    Compound: GSH
    Cytotoxicity against human KB-3-1 cells incubated for 72 hrs by MTT assay
    Cytotoxicity against human KB-3-1 cells incubated for 72 hrs by MTT assay
    		[PMID: 21657271]
    KB-V1 IC50
    >20 mM
    Compound: GSH
    Cytotoxicity against drug-resistant human KBV1 cells expressing P-gp incubated for 72 hrs by MTT assay
    Cytotoxicity against drug-resistant human KBV1 cells expressing P-gp incubated for 72 hrs by MTT assay
    		[PMID: 21657271]
    In Vitro

    L-Glutathione reduced is a non-protein thiol widely exists in living cells. L-Glutathione reduced plays important biological functions in the organism, including protein and DNA synthesis, enzyme activity, metabolism and cell protection. L-Glutathione reduced is capable of scavenging oxygen-derived free radicals and is established to be a marker of oxidative stress[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    L-Glutathione reduced Related Antibodies
    Masse moléculaire

    307.32

    Formule

    C10H17N3O6S
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    Structure Classification
    Initial Source
    Livraison

    Room temperature in continental US; may vary elsewhere.
    Stockage

    4°C, protect from light, stored under nitrogen

    *The compound is unstable in solutions, freshly prepared is recommended.

    Solvant et solubilité
    In Vitro: 

    H2O : 62.5 mg/mL (203.37 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.2539 mL 16.2697 mL 32.5394 mL
    5 mM 0.6508 mL 3.2539 mL 6.5079 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Calculateur de molarité

    • Calculateur de dilution

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (325.39 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Pureté et documentation

    Purity: 99.79%

    SDS (394 KB)

    COA (244 KB) HNMR (254 KB) LCMS (87 KB)

    Instruction de manipulation (2659 KB)
    Références

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 3.2539 mL 16.2697 mL 32.5394 mL 81.3484 mL
    5 mM 0.6508 mL 3.2539 mL 6.5079 mL 16.2697 mL
    10 mM 0.3254 mL 1.6270 mL 3.2539 mL 8.1348 mL
    15 mM 0.2169 mL 1.0846 mL 2.1693 mL 5.4232 mL
    20 mM 0.1627 mL 0.8135 mL 1.6270 mL 4.0674 mL
    25 mM 0.1302 mL 0.6508 mL 1.3016 mL 3.2539 mL
    30 mM 0.1085 mL 0.5423 mL 1.0846 mL 2.7116 mL
    40 mM 0.0813 mL 0.4067 mL 0.8135 mL 2.0337 mL
    50 mM 0.0651 mL 0.3254 mL 0.6508 mL 1.6270 mL
    60 mM 0.0542 mL 0.2712 mL 0.5423 mL 1.3558 mL
    80 mM 0.0407 mL 0.2034 mL 0.4067 mL 1.0169 mL
    100 mM 0.0325 mL 0.1627 mL 0.3254 mL 0.8135 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    L-Glutathione reduced Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    L-Glutathione reduced70-18-8GSH γ-L-Glutamyl-L-cysteinyl-glycineEndogenous MetaboliteReactive Oxygen Species (ROS)FerroptosisInhibitorinhibitorinhibit

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