L-Glutathione reduced monosodium
Based on 56 publication(s) in Google Scholar
L-Glutathione reduced monosodium is an endogenous antioxidant and is capable of scavenging oxygen-derived free radicals.
For research use only. We do not sell to patients.
- CAS No.: 20167-21-9
- Formula: C10H16N3NaO6S
- Molecular Weight:329.31
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications Citing Use of MedChemExpress (MCE) L-Glutathione reduced monosodium
More- Signal Transduct Target Ther. 2021 May 28;6(1):188. [Abstract]
- Signal Transduct Target Ther. 2020 May 8;5(1):51. [Abstract]
- Nat Nanotechnol. 2025 Apr 23. [Abstract]
- Bone Res. 2024 Aug 27;12(1):47. [Abstract]
- Nat Commun. 2026 Mar 13;17(1):3879. [Abstract]
- Nat Commun. 2025 Apr 22;16(1):3777. [Abstract]
- Angew Chem Int Ed Engl. 2025 Sep 16:e202511471. [Abstract]
- J Adv Res. 2025 Aug:74:589-607. [Abstract]
- J Am Chem Soc. 2026 Mar 11;148(9):10225-10240. [Abstract]
- Redox Biol. 2025 Jul:84:103693. [Abstract]
- Redox Biol. 2022 Aug;54:102392. [Abstract]
- Nat Chem Biol. 2025 Mar;21(3):371-382. [Abstract]
- Acta Pharm Sin B. 2021 Dec;11(12):4045-4054. [Abstract]
- J Exp Clin Cancer Res. 2023 Jun 6;42(1):142. [Abstract]
- Adv Sci (Weinh). 2025 Feb;12(6):e2411479. [Abstract]
- Cell Rep Med. 2026 Mar 17;7(3):102635. [Abstract]
- Carbohydr Polym. 2025 Mar 1:351:123123. [Abstract]
- J Allergy Clin Immunol. 2022 Sep;150(3):727-735.e6. [Abstract]
- Int J Biol Sci. 2022 Jan 1;18(2):717-730. [Abstract]
- Cell Death Discov. 2025 Nov 7;11(1):511. [Abstract]
- Acta Pharmacol Sin. 2025 Jun 11. [Abstract]
- Biomater Res. 2025 Nov 17:29:0246. [Abstract]
- J Transl Med. 2024 Feb 21;22(1):192. [Abstract]
- Proc Natl Acad Sci U S A. 2025 Oct 7;122(40):e2502841122. [Abstract]
- Dev Cell. 2024 Feb 26;59(4):517-528.e3. [Abstract]
- Int J Biol Macromol. 2026 Mar:352:151224. [Abstract]
- Int J Biol Macromol. 2025 Dec;333(Pt 1):148831. [Abstract]
- Free Radic Biol Med. 2026 Aug 1:251:229-242. [Abstract]
- Free Radic Biol Med. 2021 Dec:177:143-155. [Abstract]
- Cell Rep. 2025 Dec 10;44(12):116671. [Abstract]
- Cell Rep. 2025 Jul 12;44(7):116014. [Abstract]
- Chin J Nat Med. 2020 Jan;18(1):57-69. [Abstract]
- Anal Chem. 2026 Jan 23. [Abstract]
- Bioeng Transl Med. 2022 Jul 30;8(1):e10377. [Abstract]
- Mar Drugs. 2025 Mar 28;23(4):146. [Abstract]
- Int J Mol Sci. 2023 Apr 20;24(8):7608. [Abstract]
- Int J Mol Sci. 2022 Apr 26;23(9):4783. [Abstract]
- mBio. 2023 Feb 28;14(1):e0237022. [Abstract]
- Chem Biol Interact. 2026 Jun 1:432:112059. [Abstract]
- Nanoscale. 2026 Apr 14. [Abstract]
- Chem Biol Interact. 2025 Sep 5:418:111614. [Abstract]
- Molecules. 2023 Apr 11;28(8):3375. [Abstract]
- Sci Rep. 2025 Jan 2;15(1):596. [Abstract]
- Brain Res Bull. 2026 Feb:235:111753. [Abstract]
- Water Biol Secur. 2025 Nov 13.
- BMC Cancer. 2022 Jul 2;22(1):724. [Abstract]
- J Chromatogr A. 2024 Apr 12:1720:464776. [Abstract]
- J Cancer. 2022 Sep 6;13(11):3234-3243. [Abstract]
- Kaohsiung J Med Sci. 2023 Jul;39(7):699-709. [Abstract]
- Life Sci Alliance. 2021 Jun 18;4(8):e202000906. [Abstract]
- Discov Oncol. 2025 Aug 15;16(1):1557. [Abstract]
- SSRN. 2025 Jan 14.
- Biomed Pharmacother. 2024 Jun:175:116727. [Abstract]
- SSRN. 2023 Nov 17.
- Research Square Print. October 14th, 2022.
- Research Square Preprint. 2022 Jan.
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RT-PCR
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Cell Proliferation/Viability Assay
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Cell Proliferation/Viability Assay
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Cell Proliferation/Viability Assay
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Cell Proliferation/Viability Assay
All Endogenous Metabolite Isoforms
More
Biological Activity
Chemical Information
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CAS No. 20167-21-9
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Molecular Weight 329.31
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Formula C10H16N3NaO6S
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SMILES
O=C(O[Na])CNC([C@H](CS)NC(CC[C@H](N)C(O)=O)=O)=O
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Synonyms
GSH monosodium; γ-L-Glutamyl-L-cysteinyl-glycine monosodium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (56)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Cyst(e)ine in nutrition formulation promotes colon cancer growth and chemoresistance by activating mTORC1 and scavenging ROS. [Abstract]2021 May 28;6(1):188. PMID: 34045438 -
Signal Transduct Target Ther
Erianin, a novel dibenzyl compound in Dendrobium extract, inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis. [Abstract]2020 May 8;5(1):51. PMID: 32382060
L-Glutathione reduced monosodium purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2020 May 8;5(1):51. [Abstract]
H460 and H1299 cells were treated with erianin with or without the ROS scavenger GSH (1 mM) for 24 h, and cell viability was assayed.
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Nat Nanotechnol
Ferumoxytol promotes haematopoietic stem cell post-injury regeneration as a reactive oxygen species scavenger. [Abstract]2025 Apr 23. PMID: 40269251 -
Bone Res
The HOXC10/NOD1/ERK axis drives osteolytic bone metastasis of pan-KRAS-mutant lung cancer. [Abstract]2024 Aug 27;12(1):47. PMID: 39191757 -
Nat Commun
2026 Mar 13;17(1):3879. PMID: 41820364 -
Nat Commun
Chloroplast precursor protein preClpD overaccumulation triggers multilevel reprogramming of gene expression and a heat shock-like response. [Abstract]2025 Apr 22;16(1):3777. PMID: 40263324
L-Glutathione reduced monosodium purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Apr 22;16(1):3777. [Abstract]
RT‒qPCR analyses demonstrated that the transcriptional upregulation of sHSP genes (17.4, 17.6A, 21, 23.5) in ClpD-GFP line #5 was suppressed by the ROS scavenging reagent GSH (500 µM, 2 days). HSP18.5 and the transcripts encoding two large HSPs (HSP90C and mtHSC70-1) were used as negative controls.
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Angew Chem Int Ed Engl
Fe-O-Mo Site-Activated Nanozymes for Bienzymatic/Upconversion Synergistic Catalytic Anticancer Therapy. [Abstract]2025 Sep 16:e202511471. PMID: 40958476 -
J Adv Res
Salidroside sensitizes Triple-negative breast cancer to ferroptosis by SCD1-mediated lipogenesis and NCOA4-mediated ferritinophagy. [Abstract]2025 Aug:74:589-607. PMID: 39353532
L-Glutathione reduced monosodium purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Aug:74:589-607. [Abstract]
Cell viability was measured after being pretreated with Fer-1 (2 μM), GSH (1 mM), or DFO (50 μM) for 1 h, and then treated with or without Sal (50 μM) for 24 h (n = 6).
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J Am Chem Soc
Safe and Highly Efficient Lipid-Pro-Dexamethasone Nanoparticles for mRNA Delivery and Base Editing. [Abstract]2026 Mar 11;148(9):10225-10240. PMID: 41733506 -
Redox Biol
Dysregulated lipids homeostasis disrupts CHAC1-mediated ferroptosis driving fibroblast growth factor receptor tyrosine kinase inhibitor AZD4547 resistance in gastric cancer. [Abstract]2025 Jul:84:103693. PMID: 40460553
L-Glutathione reduced monosodium purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Jul:84:103693. [Abstract]
BR-CHAC1-OE and MR-CHAC1-OE cells were treated with DMSO, AZD4547 (2.5 μM) with or without GSH (10 mM) and NAC (5 mM) for 72 h, and cell viability was measured by the CCK-8 assay.
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Redox Biol
Dissecting the process of human neutrophil lineage determination by using alpha-lipoic acid inducing neutrophil deficiency model. [Abstract]2022 Aug;54:102392. PMID: 35797799 -
Nat Chem Biol
2025 Mar;21(3):371-382. PMID: 39060389 -
Acta Pharm Sin B
2021 Dec;11(12):4045-4054. PMID: 35024325
L-Glutathione reduced monosodium purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2021 Dec;11(12):4045-4054. [Abstract]
KU-19-19 was treated with baicalin with or without glutathione (GSH) (1.5 mM) for 24 h, then cell viability was analyzed.
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J Exp Clin Cancer Res
Ferroptosis inducers enhanced cuproptosis induced by copper ionophores in primary liver cancer. [Abstract]2023 Jun 6;42(1):142. PMID: 37277863 -
Adv Sci (Weinh)
Addressing Clinical Limitations of Glutaminase Inhibitors: Novel Strategies for Osimertinib-Resistant Lung Cancer by Exploiting Glutamine Metabolic Dependency. [Abstract]2025 Feb;12(6):e2411479. PMID: 39680480 -
Cell Rep Med
Enhancing gastric cancer immunotherapy: Insights from multi-omics analysis and innovations in photodynamic-chemotherapy nanoplatforms. [Abstract]2026 Mar 17;7(3):102635. PMID: 41747719 -
Carbohydr Polym
Hijacking the hyaluronan assisted iron endocytosis to promote the ferroptosis in anticancer photodynamic therapy. [Abstract]2025 Mar 1:351:123123. PMID: 39779030 -
J Allergy Clin Immunol
Untargeted metabolomic profiling identifies disease-specific and outcome-related signatures in chronic rhinosinusitis. [Abstract]2022 Sep;150(3):727-735.e6. PMID: 35460727 -
Int J Biol Sci
2022 Jan 1;18(2):717-730. PMID: 35002520 -
Cell Death Discov
Pregnane X receptor protects against age-related bone loss in males via PI3K/Akt-mediated inhibition of apoptosis. [Abstract]2025 Nov 7;11(1):511. PMID: 41203627 -
Acta Pharmacol Sin
Targeting PPARα activation sensitizes glioblastoma cells to temozolomide and reverses acquired resistance by inhibiting H3K18 lactylation. [Abstract]2025 Jun 11. PMID: 40500345 -
Biomater Res
A Multimodal Energy-Depletion Strategy for Cooperative Tumor Metabolism Regulation in Enhanced Cancer Therapy. [Abstract]2025 Nov 17:29:0246. PMID: 41255515 -
J Transl Med
ZSWIM4 inhibition improves chemosensitivity in epithelial ovarian cancer cells by suppressing intracellular glycine biosynthesis. [Abstract]2024 Feb 21;22(1):192. PMID: 38383406 -
Proc Natl Acad Sci U S A
Mitochondrial ROS triggers mitophagy through activating the DNA damage response signaling pathway. [Abstract]2025 Oct 7;122(40):e2502841122. PMID: 41026812 -
Dev Cell
A single fluorescent probe to examine the dynamics of mitochondria-lysosome interplay and extracellular vesicle role in ferroptosis. [Abstract]2024 Feb 26;59(4):517-528.e3. PMID: 38272028 -
Int J Biol Macromol
Reticuline isomerase AKR1B1 with aldo-keto reductase activity and detoxification function from the insect Blaps rhynchopetera. [Abstract]2026 Mar:352:151224. PMID: 41791543 -
Int J Biol Macromol
S100A4 regulates ferroptosis to suppress cell proliferation via the SLC7A11-GSH axis but facilitates Brucella infection in RAW264.7 macrophages. [Abstract]2025 Dec;333(Pt 1):148831. PMID: 41203174 -
Free Radic Biol Med
DLAT sustains redox homeostasis and prevent colorectal cancer from ferroptosis by regulating SLC25A39-mediated mitochondrial glutathione transport. [Abstract]2026 Aug 1:251:229-242. PMID: 42009144 -
Free Radic Biol Med
Jejunal epithelial barrier disruption triggered by reactive oxygen species in early SIV infected rhesus macaques. [Abstract]2021 Dec:177:143-155. PMID: 34687865 -
Cell Rep
Microglial macrophage-derived ds-HMGB1 in DRG orchestrates neuropathic pain through immune-neural signaling. [Abstract]2025 Dec 10;44(12):116671. PMID: 41385369 -
Cell Rep
Oxidative stress and Kras mutation in Mist1+ cells act in a double-hit manner to drive gastric tumorigenesis. [Abstract]2025 Jul 12;44(7):116014. PMID: 40652510 -
Chin J Nat Med
The crucial role of metabolic regulation in differential hepatotoxicity induced by furanoids in Dioscorea bulbifera. [Abstract]2020 Jan;18(1):57-69. PMID: 31955824 -
Anal Chem
Viability-Informed Single-Cell Mass Spectrometry for More Comprehensive Metabolic Analysis. [Abstract]2026 Jan 23. PMID: 41574827 -
Bioeng Transl Med
Nanoalbumin-prodrug conjugates prepared via a thiolation-and-conjugation method improve cancer chemotherapy and immune checkpoint blockade therapy by promoting CD8+ T-cell infiltration. [Abstract]2022 Jul 30;8(1):e10377. PMID: 36684090 -
Mar Drugs
Xanthocillin X Dimethyl Ether Exhibits Anti-Proliferative Effect on Triple-Negative Breast Cancer by Depletion of Mitochondrial Heme. [Abstract]2025 Mar 28;23(4):146. PMID: 40278267 -
Int J Mol Sci
MTX-211 Inhibits GSH Synthesis through Keap1/NRF2/GCLM Axis and Exerts Antitumor Effects in Bladder Cancer. [Abstract]2023 Apr 20;24(8):7608. PMID: 37108769 -
Int J Mol Sci
Ferroptosis and Apoptosis Are Involved in the Formation of L-Selenomethionine-Induced Ocular Defects in Zebrafish Embryos. [Abstract]2022 Apr 26;23(9):4783. PMID: 35563172 -
mBio
2023 Feb 28;14(1):e0237022. PMID: 36507835 -
Chem Biol Interact
Co-exposure to PS-NPs and HFPO-TA potentiates reproductive toxicity via ferroptosis and SLC1A5-Mediated glutamine deprivation in male mice. [Abstract]2026 Jun 1:432:112059. PMID: 41887313 -
Nanoscale
Targeting glutamine metabolism combined with a nanoradioenhancer in radioresistant hepatocellular carcinoma. [Abstract]2026 Apr 14. PMID: 41978422 -
Chem Biol Interact
Metallothioneins protect against isoconazole nitrate-induced antitumor activity through the maintenance of cellular redox homeostasis in hepatocellular carcinoma. [Abstract]2025 Sep 5:418:111614. PMID: 40541645 -
Molecules
Untargeted Metabolomics Using UHPLC-HRMS Reveals Metabolic Changes of Fresh-Cut Potato during Browning Process. [Abstract]2023 Apr 11;28(8):3375. PMID: 37110608 -
Sci Rep
Chemotherapeutic hormesis induced by the tumor microenvironment in refractory ovarian cancer. [Abstract]2025 Jan 2;15(1):596. PMID: 39747971 -
Brain Res Bull
Nerol ameliorates cognitive dysfunction in vascular dementia rats by inhibiting mitochondrial oxidative stress and reducing hippocampal senescence. [Abstract]2026 Feb:235:111753. PMID: 41619816 -
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BMC Cancer
2022 Jul 2;22(1):724. PMID: 35778693 -
J Chromatogr A
Preparation of thiol-free amino acid plasma matrix for quantification of thiol amino acids and their oxidized forms in human plasma by UPLC-MS/MS. [Abstract]2024 Apr 12:1720:464776. PMID: 38432109 -
J Cancer
Combination of Metformin and Sorafenib Induces Ferroptosis of Hepatocellular Carcinoma Through p62-Keap1-Nrf2 Pathway. [Abstract]2022 Sep 6;13(11):3234-3243. PMID: 36118519 -
Kaohsiung J Med Sci
Dihydroartemisinin enhances gefitinib cytotoxicity against lung adenocarcinoma cells by inducing ROS-dependent apoptosis and ferroptosis. [Abstract]2023 Jul;39(7):699-709. PMID: 37057810 -
Life Sci Alliance
HCV poly U/UC sequence-induced inflammation leads to metabolic disorders in vulvar lichen sclerosis. [Abstract]2021 Jun 18;4(8):e202000906. PMID: 34145025 -
Discov Oncol
UBE2C-mediated ubiquitination of ACSL4 inhibits ferroptosis and promotes gastric cancer progression. [Abstract]2025 Aug 15;16(1):1557. PMID: 40813933 -
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Biomed Pharmacother
Elesclomol-copper synergizes with imidazole ketone erastin by promoting cuproptosis and ferroptosis in myelodysplastic syndromes. [Abstract]2024 Jun:175:116727. PMID: 38733771 -
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Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)