2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species (ROS) Endogenous Metabolite
  4. Lycopene

Lycopene is naturally occurring carotenoids found in tomato, tomato products, and in other red fruits and vegetables; exhibits antioxidant effects.

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CAS No. : 502-65-8

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Based on 19 publication(s) in Google Scholar

Other Forms of Lycopene:

Lycopene Related Antibodies

Top Publications Citing Use of Products

    Lycopene purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2025 Sep 15:303:119045.  [Abstract]

    Effect of different concentrations of Lycopene (LYC) (0, 5, 10, 20, 30, 40, 50 μM) on cell viability.

    Lycopene purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2025 Sep 15:303:119045.  [Abstract]

    ZEA decreased the protein levels of GPX4 and FTH1 . Nevertheless, pretreatment with Lycopene (LYC) (20 μM) counteracted these effects induced by ZEA in AML-12 cells.

    Lycopene purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2025 Sep 15:303:119045.  [Abstract]

    Morphological change of liver tissues from each group by HE staining, Lycopene (LYC) (5 mg/kg, i.g.) attenuated ZEA-induced hepatocyte injury in mice.

    Lycopene purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Jun;11(24):e2309590.  [Abstract]

    DNA cleavage efficiencies of gel electrophoresis under Lycopene (50 mM) with light for 30 min and subsequently without light till 4 h.

    Lycopene purchased from MedChemExpress. Usage Cited in: Redox Biol. 2020 Sep;36:101601.  [Abstract]

    PK-15 cells were incubated with 50 nM Si-DMA and different concentrations of LJ002. The generation of 1O2 in the absence or presence of 1 μM Lycopene for 1 h was observed with fluorescence microscopy.

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    Human Endogenous Metabolite Microbial Metabolite

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    Description

    Lycopene is naturally occurring carotenoids found in tomato, tomato products, and in other red fruits and vegetables; exhibits antioxidant effects.

    IC50 & Target

    Human Endogenous Metabolite

     

    Cellular Effect
    Cell Line Type Value Description References
    Platelet IC50
    5.8 μM
    Compound: Lycopene
    Inhibition of collagen-induced platelet aggregation in human platelet suspension preincubated for 3 mins followed by collagen stimulation and measured after 6 mins by lumi-aggregometry
    Inhibition of collagen-induced platelet aggregation in human platelet suspension preincubated for 3 mins followed by collagen stimulation and measured after 6 mins by lumi-aggregometry
    		[PMID: 32463237]
    Platelet IC50
    6.2 μM
    Compound: Lycopene
    Inhibition of ADP-induced platelet aggregation in human platelet suspension preincubated for 3 mins followed by collagen stimulation and measured after 6 mins by lumi-aggregometry
    Inhibition of ADP-induced platelet aggregation in human platelet suspension preincubated for 3 mins followed by collagen stimulation and measured after 6 mins by lumi-aggregometry
    		[PMID: 32463237]
    Platelet IC50
    6.8 μM
    Compound: Lycopene
    Inhibition of arachidonic acid-induced platelet aggregation in human platelet suspension preincubated for 3 mins followed by collagen stimulation and measured after 6 mins by lumi-aggregometry
    Inhibition of arachidonic acid-induced platelet aggregation in human platelet suspension preincubated for 3 mins followed by collagen stimulation and measured after 6 mins by lumi-aggregometry
    		[PMID: 32463237]
    In Vitro

    Sufficient uptake of lycopene from the diet is necessary to benefit from its health promoting effects, since humans are unable to synthesise lycopene de novo. Lycopene significantly inhibits prostate and breast cancer cell growth at physiologically relevant concentrations of 1.25 μM and also causes a 30-40 % reduction in inhibitor of kappa B phosphorylation in the cells[1].
    Increased intake of lycopene, a major carotenoid in tomatoes, consumed as the all-trans-isomer attenuates alcohol induced apoptosis in 2E1 cells and reduces risk of prostate, lung and digestive cancers. Lycopene plays a role in the protection against photooxidative processes by acting as singlet molecular oxygen and peroxyl radicals scavengers and can interact synergistically with other antioxidants[2].
    Lycopene as a carotenoid can react with types of reactive oxygen species (ROS) in three different mechanisms: I) by electron-transfer, II) by hydrogen atom transfer or III) by adduct formation. Lycopene is able to deactivate singlet oxygen mainly by physical quenching[3].
    Lycopene decreases ROS production in SK-Hep-1 cells through inhibition of NADPH oxidase, brought about in the PKC pathway[5].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Lycopene Related Antibodies
    In Vivo

    Lycopene is the most predominant carotenoid in human plasma and has a half life of about 2-3 days[2].
    Lycopene or processed tomatoes may lead to a reduction of intima-media thickness in vessel walls[3].
    Lycopene exerts protective effects against ATZ-induced toxicity in rat adrenal cortex. These effects may be attributed to the antioxidative property of lycopene and its ability to activate the Nrf2/HO-1 pathway[4].
    Lycopene improves hepatotoxicity acting as an antioxidant, reduces GSSG and regulates tGSH and CAT levels, reduces oxidative damage[5].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    Molecular Weight

    536.87

    Formula

    C40H56
    CAS No.
    Appearance

    Solid

    Color

    Purple to red

    SMILES

    C/C(C)=C\CC/C(C)=C/C=C/C(C)=C/C=C/C(C)=C/C=C/C=C(/C=C/C=C(C)/C=C/C=C(CC/C=C(C)\C)\C)C
    Structure Classification
    Initial Source
    Shipping

    Shipping with dry ice.
    Storage

    -80°C, protect from light, stored under nitrogen
    Solvent & Solubility
    In Vitro: 

    THF : 5 mg/mL (9.31 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.8626 mL 9.3132 mL 18.6265 mL
    5 mM 0.3725 mL 1.8626 mL 3.7253 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

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    (per animal)

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    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Purity & Documentation

    Purity: 99.86%

    SDS (394 KB)

    COA (237 KB) HNMR (289 KB) RP-HPLC (205 KB)

    Handling Instructions (2659 KB)
    References
    Cell Assay
    [1]

    PC3 cells and MDA-MB-231 cells are treated with (0, 0.5, 1.25, 2.5 and 5 μM) lycopene for 48 h. Cell survival/growth is measured using the colorimetric MTS assay method. MTS-PMS complex (20 μL) is added to each well. The catalytic activity of viable cells results in formazan dye production, which is then quantified. Cells are incubated with the dye for 1 h, followed by absorbance reading at 492 nm on a spectrophotometer[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Animal Administration
    [4]

    Rats: Lycopene is dissolved in corn oil. 35 adult male albino rats are randomized into five equal groups: untreated control, vehicle control (receives 0.5 mL corn oil/day), lycopene (10 mg/kg b.w./day), ATZ (dissolved in 0.5 mL corn oil 300 mg/kg b.w./day), and ATZ + lycopene. All treatments are given by oral gavage for 4 weeks[4].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    THF 1 mM 1.8626 mL 9.3132 mL 18.6265 mL 46.5662 mL
    5 mM 0.3725 mL 1.8626 mL 3.7253 mL 9.3132 mL
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    Lycopene Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Lycopene502-65-8Reactive Oxygen Species (ROS)Endogenous MetaboliteInhibitorinhibitorinhibit

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