2. Epigenetics PI3K/Akt/mTOR Metabolic Enzyme/Protease Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor
  3. AMPK PPAR Glucokinase
  4. Palmitelaidic acid

Palmitelaidic acid  (Synonyms: 9-trans-Hexadecenoic acid; trans-Palmitoleic acid)

製品番号: HY-N2341 純度: 99.4%
COA 取扱説明書 Technical Support

Palmitelaidic acid (9-trans-Hexadecenoic acid) is the trans isomer of palmitoleic acid. Palmitoleic acid is one of the most abundant fatty acids in serum and tissue.

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Palmitelaidic acid

Palmitelaidic acid 構造式

CAS 番号 : 10030-73-6

容量 価格（税別） 在庫状況 数量
Solvent
10 mg (393 mM * 100 μL in Ethanol) USD 50 在庫あり
Solvent
25 mg (393 mM * 250 μL in Ethanol) USD 100 在庫あり
Solvent
50 mg (393 mM * 500 μL in Ethanol) USD 160 在庫あり

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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Based on 3 publication(s) in Google Scholar

Other Forms of Palmitelaidic acid:

Palmitelaidic acid 関連抗体

Top Publications Citing Use of Products

AMPK アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1 BRSK1 BRSK2 HUNK AMPKα

PPAR アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
PPARα PPARβ/δ PPARγ PPAR PPARδ

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製品説明

Palmitelaidic acid (9-trans-Hexadecenoic acid) is the trans isomer of palmitoleic acid. Palmitoleic acid is one of the most abundant fatty acids in serum and tissue.

IC50 & Target[2]

AMPK

 

PPARα

 

Glucokinase

 

体外実験

The monounsaturated fatty acid palmitoleate (palmitoleic acid) is one of the most abundant fatty acids in serum and tissues, particularly adipose tissue and liver. Its endogenous production by stearoyl-CoA desaturase 1 gives rise to its cis isoform, cis-palmitoleate. Palmitoleic acid has been correlated with multiple cardiometabolic risk factors, including high blood pressure, total cholesterol, TGs, apoA-I, apoB, and endothelial dysfunction[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Palmitelaidic acid 関連抗体
体内実験

Palmitoleic acid promotes a faster uptake of glucose in the body, associated with higher insulin concentration. Palmitoleic acid increases the phosphorylation of AMPK, up-regulates glucokinase and down-regulates SREBP-1. Regarding AMPK downstream, palmitoleic acid increases the production of FGF-21 and stimulates the expression of PPARα[2]. Palmitoleic acid reduces body weight increase, ameliorates the development of hyperglycemia and hypertriglyceridemia, and improves insulin sensitivity. Furthermore, palmitoleic acid down-regulates mRNA expressions of proinflammatory adipocytokine genes (TNFα and resistin) in white adipose tissue and lipogenic genes (SREBP-1, FAS, and SCD-1) in liver[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

254.41

分子式

C16H30O2
CAS 番号
Appearance

Liquid

Color

Colorless to light yellow

SMILES

CCCCCC/C=C/CCCCCCCC(O)=O
Structure Classification
Initial Source

 beef samples
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Solution, -20°C, 2 years
純度とドキュメンテーション

純度: 99.4%

COA (238 KB)

取扱説明書 (2659 KB)
参考文献
動物実験
[2]

Mice: Male C57BL/6J wild type and PPARα-KO mice are fed a high-fat diet or a standard diet for 12 weeks. In the last two weeks, the HF-fed mice are treated daily with oleic acid (300 mg/kg of body weight) or palmitoleic acid (00 mg/kg of body weight) by oral gavage. After 12 weeks, the mice are fasted for 6 h, injected with insulin or PBS vehicle. Blood and liver samples are collected and stored for the further analysis of RNA and protein expression[2].

MedChemExpress (MCE) はこれらの方法の精度を確認していません。 こちらは参照専用です。
参考文献
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Palmitelaidic acid Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Palmitelaidic acid10030-73-69-trans-Hexadecenoic acid trans-Palmitoleic acidAMPKPPARGlucokinaseAMP-activated protein kinasePeroxisome proliferator-activated receptorsHexokinase IVHexokinase DInhibitorinhibitorinhibit

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