2. Infection

Infection

Infection

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Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-185207
    CQ80 3034207-17-2 98%
    CQ80 is a PEPD/XPNPEP1 inhibitor and selective CARD8 inflammasome activator. CQ80 has IC50 values of 0.91 μM for PEPD, 43 μM for XPNPEP1. CQ80 promotes the accumulation of Xaa-Pro peptides by inhibiting PEPD and XPNPEP1, releases the fragment of CARD8 for inflammasome formation, and induces pyroptosis via GSDMD cleavage. CQ80 can be used for research on inflammasome, CARD8-expressing cancer cells, HIV-1-infected cell clearance, acute myeloid leukemia (AML).
    CQ80
  • HY-185351
    Ampicillin sodium and Sulbactam sodium
    Ampicillin sodium and Sulbactam sodium are formed by mixing HY-B0522A Ampicillin sodium with HY-B0334A Sulbactam sodium (each 1.5 g of this product contains 1 g amoxicillin sodium and 0.5 g sulbactam sodium). Ampicillin is a β-lactam antimicrobial, whereas sulbactam is a β-lactamase inhibitor. Ampicillin has a broad spectrum of bactericidal activity against many gram-positive and gram-negative aerobic and anaerobic bacteria. However, ampicillin is degraded by beta-lactamases. The combination of ampicillin and sulbactam demonstrates synergy in addressing bacterial strains resistant to ampicillin, thus providing broader coverage. Bacteria susceptible to ampicillin/sulbactam include Haemophilus influenzae, Escherichia coli, Acinetobacter, Klebsiella, Staphylococcus aureus, Enterobacter, and anaerobes.
    Ampicillin sodium and Sulbactam sodium
  • HY-185443
    UCP1172 1922152-04-2
    UCP1172 is an antibacterial (Antibacterial) agent and Dihydrofolate reductase inhibitor, with an IC50 of 0.0089 μM against Staphylococcus aureus DfrB, 0.22 μM against DfrG, 0.41 μM against DfrA, and 0.030 μM against DfrK. UCP1172 potently inhibits the growth of MRSA/MSSA isolates carrying dfrG and dfrK (MIC values of 0.3125-0.625 μg/mL), shows weak activity against MRSA carrying dfrA (MIC of 5 μg/mL), and exerts extremely potent inhibitory effects on wild-type S. aureus ATCC 43300 (MIC of 0.0098 μg/mL). UCP1172 can be used in studies related to tuberculosis and Staphylococcus aureus infections.
    UCP1172
  • HY-185448
    HIV RT-IN-1 1246741-36-5
    HIV RT-IN-1 is an inhibitor of HIV integrase and HIV reverse transcriptase-associated ribonuclease H. HIV RT-IN-1 is applicable to research related to HIV-1 infection.
    HIV RT-IN-1
  • HY-185449
    HIV RT-IN-2 1909302-89-1
    HIV RT-IN-2 is a HIV reverse transcriptase inhibitor with an IC50 value of 1.2 μM for HIV-1 RT RNA-dependent DNA polymerase. HIV RT-IN-2 potently inhibits all three modes of HIV-1 RT-associated RNase H activity (internal, 3'-DNA directed, 5'-RNA directed cleavage) and inhibits HIV-1 replication. HIV RT-IN-2 can be used for the research of HIV-1 infection.
    HIV RT-IN-2
  • HY-185574
    Enpyracymid 2757172-25-9
    Enpyracymid is a succinate dehydrogenase inhibitor (SDHI) fungicide with fungicidal activity against fungal. It can be used in studies related to Fusarium head blight (FHB).
    Enpyracymid
  • HY-185765
    MC-PEG4-β-Glu-Baloxavir
    MC-PEG4-β-Glu-Baloxavir is a conjugate of a toxin molecule and a linker, with Baloxavir (HY-109025A) as the payload. Baloxavir is an effective and selective inhibitor of cap-dependent nucleases (CEN). Baloxavir inhibits the transcription and replication of viral RNA and has strong antiviral activity.
    MC-PEG4-β-Glu-Baloxavir
  • HY-186020
    L-4-Aminoarabinose-bactoprenyl phosphate 402491-79-6 98%
    L-4-Aminoarabinose-bactoprenyl phosphate (L-4-Aminoarabinose-BP) is a substrate of the ArnT enzyme and participates in lipid A modification through covalent bonding. L-4-Aminoarabinose-bactoprenyl phosphate transfers L-4-aminoarabinose (Ara4N) to the lipid A portion of lipopolysaccharide (LPS), mediating cationic modification of lipid A, thereby conferring resistance to cationic antimicrobial peptides (CAMPs) in Gram-negative bacteria. L-4-Aminoarabinose-bactoprenyl phosphate is an endogenous intermediate synthesized in vivo by a series of enzymes such as ArnC and ArnD encoded by the arn operon in Gram-negative bacteria such as Escherichia coli.
    L-4-Aminoarabinose-bactoprenyl phosphate
  • HY-186074
    ERβ agonist-2 628321-25-5
    ERβ agonist-2 (Page 72) is a selective ERβ agonist with an EC50 of 800 nM or lower. ERβ agonist-2 selectively inhibits T cell activation and/or proliferation, thereby reducing circulating T cell levels in subjects, without exerting significant effects on circulating neutrophil, monocyte or B cell levels. ERβ agonist-2 is applicable to studies of chronic heart failure after myocardial infarction, as well as graft-versus-host disease, multiple sclerosis and experimental autoimmune encephalomyelitis.
    ERβ agonist-2
  • HY-186076
    Hsp90-IN-47 958888-13-6
    Hsp90-IN-47 (Compound C15) is a Hsp90 inhibitor and antifungal agent, with an IC50 of 0.014 μM against Hsp90α. When combined with Fluconazole (HY-B0101), Hsp90-IN-47 exerts significant synergistic antifungal effects against fluconazole-resistant Candida albicans 0304103. Hsp90-IN-47 exhibits antitumor activity against acute myeloid leukemia and non-small cell lung cancer.
    Hsp90-IN-47
  • HY-186103
    Glycolipid C34 1204401-08-0
    Glycolipid C34, α-GalCer (HY-102022) analog, is a CD1d-binding glycolipid antinfection agent. Glycolipid C34 mediates invariant natural killer T cell activation and increases the secretion of IFN-γ and IL-4. Glycolipid C34 promotes clearance of bacterial infections in murine models and enhances protective immunity against viral infections. Glycolipid C34 can be used for the research of bacterial infection, viral infection.
    Glycolipid C34
  • HY-186106
    3-Deoxyanguibactin 2247437-94-9
    3-Deoxyanguibactin is a siderophore and Fe(III) chelator/iron delivery agent. 3-Deoxyanguibactin binds Fe(III) with 2:1 stoichiometry in liquid phase, delivers iron into Acinetobacter baumannii cells, and relies on the BauA outer membrane receptor and bau transport system for cellular entry. 3-Deoxyanguibactin can be used for the research of acinetobacter baumannii infection.
    3-Deoxyanguibactin
  • HY-186153
    Antiviral agent 82 2236586-64-2
    Antiviral agent 82 (example 1) is an anti-HCV agent. Antiviral agent 82 can be used to prevent infection with flaviviruses, particularly hepatitis C virus.
    Antiviral agent 82
  • HY-186168
    1-Hydroxy-3-oxodecane-1-sulfonate sodium 118019-64-0
    1-Hydroxy-3-oxodecane-1-sulfonate sodium is a small-molecule acylacetaldehyde that can be used for the preparation of anti-inflammatory and bactericidal preparations.
    1-Hydroxy-3-oxodecane-1-sulfonate sodium
  • HY-186182
    PF-1010 2653350-02-6
    PF-1010 is a CD73 inhibitor with an IC50 ranging from 101 to 1000 nM. PF-1010 blocks the interaction between CD73 protein and its substrate, and inhibits the enzymatic activity of CD73. PF-1010 is applicable to the research of cancer, infectious diseases, autoimmune diseases and neurodegenerative diseases.
    PF-1010
  • HY-186189
    OPA-S-S-alkyne 3059216-68-8
    OPA-S-S-alkyne is a cell surface protein-selective labeling agent. OPA-S-S-alkyne selectively labels hyper-reactive extracellular lysines including ROR2 K382 and ENG K285, blocks ENG-BMP9 interaction, and labels purified human serum albumin with minimal bias. OPA-S-S-alkyne can be used for the research of hematologic and influenza A virus infection.
    OPA-S-S-alkyne
  • HY-186194
    6-Methoxy-γ-mangostin 18356-05-3
    6-Methoxy-γ-mangostin is a synthetic analogue of prenylated xanthone. 6-Methoxy-γ-mangostin can be used for research on bacterial infection.
    6-Methoxy-γ-mangostin
  • HY-186203
    8-Bromo-harmane 144434-73-1
    8-Bromo-harmane is a β-carboline derivative with anti-HSV-1 activity. 8-Bromo-harmane is non-cytotoxic. 8-Bromo-harmane can be used for the research of herpes simplex virus 1 (HSV-1) infection.
    8-Bromo-harmane
  • HY-186215
    Indazapyroxamet 1689545-27-4 98%
    Indazapyroxamet is an orally active insect TRPV channel (Nan/Iav subunit) modulator and insecticide. Indazapyroxamet antagonizes nicotinamide-induced calcium influx, inhibits insect motor function, and impairs negative geotaxis in wild-type Drosophila melanogaster via functional TRPV channels.
    Indazapyroxamet
  • HY-186236
    N42FTA 892706-90-0
    N42FTA is a non-covalent, non-suicidal inhibitor of FabA from Pseudomonas aeruginosa and Escherichia coli, with IC50 values of 3.27 μM and 2.31 μM, respectively. As a natural substrate mimetic, N42FTA blocks the cross-linking between acyl carrier protein and FabA in Escherichia coli. N42FTA shows no significant antibacterial activity due to poor permeability. N42FTA can be used in studies related to Pseudomonas aeruginosa and Escherichia coli infections.
    N42FTA
Cat. No. Product Name / Synonyms Application Reactivity