2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. Indazapyroxamet

Indazapyroxamet is an orally active insect TRPV channel (Nan/Iav subunit) modulator and insecticide. Indazapyroxamet antagonizes nicotinamide-induced calcium influx, inhibits insect motor function, and impairs negative geotaxis in wild-type Drosophila melanogaster via functional TRPV channels.

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Indazapyroxamet

Indazapyroxamet Chemical Structure

CAS No. : 1689545-27-4

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Indazapyroxamet Related Antibodies

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Description

Indazapyroxamet is an orally active insect TRPV channel (Nan/Iav subunit) modulator and insecticide. Indazapyroxamet antagonizes nicotinamide-induced calcium influx, inhibits insect motor function, and impairs negative geotaxis in wild-type Drosophila melanogaster via functional TRPV channels[1].

In Vitro

Indazapyroxamet (10 min) acts as a low-efficacy partial agonist (EC50=13.1 nM) and potent antagonist (IC50=8.1 nM) of the brown planthopper TRPV channel expressed in Drosophila S2 cells[1].
Indazapyroxamet binds to the brown planthopper TRPV channel in a pocket overlapping that of known agonists, forming a π-stacking interaction with NlIavW322 but lacking critical interactions with NlNanY178, which explains its partial agonist and antagonistic activity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Indazapyroxamet Related Antibodies
In Vivo

Indazapyroxamet (50-400 μM; p.o.; single 3-hour feeding) induces dose-dependent impairment of negative geotaxis in wild-type Drosophila with a climbing index reduction to ~0.18 at 400 μM, and this behavioral effect requires functional TRPV channels as it is completely abolished in Nan and Iav loss-of-function mutants[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: w1118 (wild-type, adult males, 2-4 days post eclosion); nan36ᵃ (adult males, 2-4 days post eclosion); iav1 (adult males, 2-4 days post eclosion); iav3621 (adult males, 2-4 days post eclosion)[1]
Dosage: 50 μM; 100 μM; 200 μM; 400 μM
Administration: p.o.; single 3-hour feeding
Result: Reduced climbing index to ~0.65 in wild-type w1118 flies at 50 μM.
Reduced climbing index to ~0.52 in wild-type w1118 flies at 100 μM.
Reduced climbing index to ~0.32 in wild-type w1118 flies at 200 μM.
Reduced climbing index to ~0.18 in wild-type w1118 flies at 400 μM.
Left climbing index unchanged in nan36ᵃ, iav1, and iav3621 TRPV loss-of-function mutants across all tested concentrations.
Molecular Weight

292.34

Formula

C17H16N4O
CAS No.
SMILES

O=C(C1=CC=CC2=NN(C3=CC=CN=C3)C=C21)NC4(CC4)C
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Indazapyroxamet Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Indazapyroxamet1689545-27-4TRP ChannelTransient receptor potential channelsnicotinamideIav subunitsNlIavW322Drosophila melanogasterNlNanY178Drosophila S2 cellsNan subunitscalcium influxNilaparvata lugensTRPV channelInhibitorinhibitorinhibit

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