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UCP1172

UCP1172 is an antibacterial (Antibacterial) agent and Dihydrofolate reductase inhibitor, with an IC₅₀ of 0.0089 μM against Staphylococcus aureus DfrB, 0.22 μM against DfrG, 0.41 μM against DfrA, and 0.030 μM against DfrK. UCP1172 potently inhibits the growth of MRSA/MSSA isolates carrying dfrG and dfrK (MIC values of 0.3125-0.625 μg/mL), shows weak activity against MRSA carrying dfrA (MIC of 5 μg/mL), and exerts extremely potent inhibitory effects on wild-type S. aureus ATCC 43300 (MIC of 0.0098 μg/mL). UCP1172 can be used in studies related to tuberculosis and Staphylococcus aureus infections.

For research use only. We do not sell to patients.

CAS No.: 1922152-04-2
Formula: C₂₄H₂₄N₄O₃
Molecular Weight:416.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

UCP1172 Chemical Structure

CAS No.: 1922152-04-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
MCF-10A	IC₅₀	100 μM Compound: 11R	Cytotoxicity against human MCF10A cells after 4 hrs by alamar blue assay Cytotoxicity against human MCF10A cells after 4 hrs by alamar blue assay	[PMID: 27437079]

In Vitro

UCP1172 (0.0098-5 μg/mL; 18 hr) potently inhibits the growth of dfrG- and dfrK-harboring MRSA/MSSA clinical isolates (MIC values 0.3125-0.625 μg/mL), shows weaker activity against dfrA-harboring MRSA (MIC 5 μg/mL), and highly potently inhibits wild-type S. aureus ATCC 43300 (MIC 0.0098 μg/mL)^[2].
UCP1172 (0.0089-0.41 μM) potently inhibits wild-type S. aureus DfrB (IC₅₀ 0.0089 μM) and TMP-resistant DfrG (IC₅₀ 0.22 μM), DfrA (IC₅₀ 0.41 μM), and DfrK (IC₅₀ 0.030 μM) DHFR enzymes, with drastically improved potency over TMP for the resistant variants^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1922152-04-2
Molecular Weight 416.47
Formula C₂₄H₂₄N₄O₃
SMILES

CCC1=NC(N)=NC(N)=C1C#C[C@@H](C2=CC(OC)=CC(C3=CC=C(C=C3)C(O)=O)=C2)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ramharack P, et al. Dual-Target Mycobacterium tuberculosis Inhibition: Insights into the Molecular Mechanism of Antifolate Drugs. Int J Mol Sci. 2023 Sep 13;24(18):14021. [Content Brief]

[2]. Reeve SM, et al. MRSA Isolates from United States Hospitals Carry dfrG and dfrK Resistance Genes and Succumb to Propargyl-Linked Antifolates. Cell Chem Biol. 2016;23(12):1458-1467. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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