2. Inflammation/Immunology

Inflammation/Immunology (炎症/免疫)

Inflammation/Immunology

関連製品

PDF 93.1 MB

The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

製品番号 製品名 CAS 番号 純度 構造式
  • HY-B2121
    6-Methoxy-2-naphthoic acid

    6-Methoxy-2-naphthoic acid

    		2471-70-7 ≥98.0%
    6-Methoxy-2-naphthoic acid (6-MNA) is the active metabolite of Nabumetone (HY-B0559). 6-Methoxy-2-naphthoic acid is also an inhibitor of COX-1 and COX-2. 6-Methoxy-2-naphthoic acid can inhibit the synthesis of gastric mucosal prostaglandin E2. 6-Methoxy-2-naphthoic acid can be used in the research of inflammation and pain-related diseases. In addition, 6-Methoxy-2-naphthoic acid is an impurity in Naproxen (HY-15030) and can also be used in the synthesis of other active compounds.
    6-Methoxy-2-naphthoic acid
  • HY-D2575
    WYneN 3052492-38-0 99.0%
    WYneN (compound 10) is a functionalized Wittig-alkyne probe. WYneN exhibits strong reactivity with sulfinic acid dipeptide models, similar to the parent Wittig reagent. WYneN can be used to reveal the function of oxidative modifications on a proteome-wide scale.
    WYneN
  • HY-N0882
    Desacetylcinobufotalin 4099-30-3 99.41%
    Desacetylcinobufotalin is an active component isolated from Venenum Bufonis, which exhibits significant cytotoxicity against human hepatocellular carcinoma HepG2 cells (IC50 = 0.0279 µmol/mL). Desacetylcinobufotalin upregulates Bax protein expression, downregulates Bcl-2 protein expression, and induces apoptosis via the mitochondrial pathway. Desacetylcinobufotalin inhibits cancer cell survival, and shows lower cytotoxicity compared to its parent compound Cinobufagin (HY-N0421). Desacetylcinobufotalin can be used in hepatocellular carcinoma-related research.
    Desacetylcinobufotalin
  • HY-N1735
    2′-Hydroxygenistein 1156-78-1 99.58%
    2′-Hydroxygenistein is a natural product that can be isolated from Crotalaria pallida and C. assamica. 2′-Hydroxygenistein shows anti-inflammatory activity. 2′-Hydroxygenistein shows significant concentration-dependent inhibitory effects on the release of β-glucuronidase and lysozyme from rat neutrophils, with IC50 values of 5.9 ± 1.4 and 9.7 ± 3.5 μM, respectively.
    2′-Hydroxygenistein
  • HY-N2012
    7-Hydroxyaristolochic acid A 79185-75-4 99.79%
    7-Hydroxyaristolochic acid A is an aristolochic acid analogue found in Aristolochia plants. Aristolochic acid can be used as an anti-inflammatory agent.
    7-Hydroxyaristolochic acid A
  • HY-N2246
    Gomisin H 66056-20-0 99.00%
    Gomisin H is a dibenzocyclooctadiene lignan isolated from the fruits of Schizandra chinensis BAILL.
    Gomisin H
  • HY-N5086
    Picroside IV 211567-04-3 99.08%
    Picroside IV is an iridoid glycoside found in the underground parts of Picrorhiza scrophulariiflora. Picroside IV is a derivative of Catalpol (HY-N0820). Catalpol has neuroprotective, hypoglycemic, anti-inflammatory, anti-cancer, anti-spasmodic, anti-oxidant effects and anti-HBV effects.
    Picroside IV
  • HY-N7327
    Ochnaflavone 50276-96-5 98.30%
    Ochnaflavone is an inhibitor of IIA-type secretory phospholipase A2 (sPLA2-IIA) with an IC50 of 3.45 µM. Ochnaflavone exhibits significant anti-inflammatory and liver-protective effects, capable of inhibiting the degradation of phosphatidylethanolamine (PE) and lipid peroxidation induced by carbon tetrachloride (CCl4) in rat liver, with an IC50 of 7.16 µM for lipid peroxidation. Ochnaflavone can be used in research on liver damage and inflammatory diseases.
    Ochnaflavone
  • HY-N7895
    Secologanic acid 60077-46-5 98.02%
    Secologanic acid is a secoiridoid glycoside. Secologanic acid inhibits NO production, the relative expression of AKT and p-AKT. Secologanic acid shows anti-inflammatory activity.
    Secologanic acid
  • HY-N8167
    Plantanone B 55780-30-8 99.16%
    Plantanone B is a moderate antioxidant-agent with an IC50 of 169.8±5.2 μM. Plantanone B shows significant ovine COX-1 and moderate COX-2 inhibitory activities. Plantanone B has the potential for inflammation-related diseases research.
    Plantanone B
  • HY-NP102
    Highly purified Type II collagen, from bovine articular cartilage 99%
    Highly purified Type II collagen, from bovine articular cartilage (Bovine Type II collagen, immunization grade), an immunization grade, is the major matrix protein in cartilage that can be used for the study of arthritis.
    Highly purified Type II collagen, from bovine articular cartilage
  • HY-P0172
    ATI-2341 1337878-62-2 99.64%
    ATI-2341 is a potent and functionally selective allosteric agonist of C-X-C chemokine receptor type 4 (CXCR4), which functions as a biased ligand, favoring Gαi activation over Gα13. ATI-2341 activates the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization. ATI-2341 is a potent and efficacious mobilizer of bone marrow polymorphonuclear neutrophils (PMNs) and hematopoietic stem and progenitor cells (HSPCs).
    ATI-2341
  • HY-103703
    DEAE Cross-linked dextran A 25 12609-80-2
    DEAE Cross-linked dextran A 25 is a weak anion exchange chromatography packing material. DEAE Cross-linked dextran A 25 can be used for the analysis of trace metal humic acid complexes in river water and the purification of biomacromolecules. DEAE Cross-linked dextran A 25 can also be used for research on diseases related to abnormal AVP levels.
    DEAE Cross-linked dextran A 25
  • HY-110269
    VUF 11222 1414376-84-3 99.91%
    VUF 11222 (Compound 38) is a CXCR3 non-peptide-like agonist. VUF 11222 can be used in the study of inflammation.
    VUF 11222
  • HY-114911
    Feprazone 30748-29-9 99.88%
    Feprazone (DA2370; Prenazone), an analogue of Phenylbutazone (HY-B0230), is a nonsteroidal anti-inflammatory agent with analgesic and antipyretic activities. Feprazone acts by inhibiting the activity of cyclooxygenase (COX)-2. Feprazone ameliorates free fatty acid (FFA)-induced oxidative stress by reducing the production of mitochondrial reactive oxygen species (ROS). Feprazone can decrease the expression of MMP-2 and MMP-9. Besides, Feprazone can suppress adipogenesis and increase lipolysis in differentiating 3 T3-L1 cells. Feprazone also can be used to research atherosclerosis and obesity.
    Feprazone
  • HY-115462
    PGN-9856 863704-91-0 98.90%
    PGN-9856 is a selective and high affinity (pKi ≥ 8.3) ligand at EP2 receptor. PGN-9856 is a potetn and non-prostanoid EP2 receptor agonist (pEC50 ≥ 8.5). PGN-9856 shows anti-inflammatory and anti-glaucoma activities.
    PGN-9856
  • HY-118028
    Leyk 1950-36-3 99.99%
    Leyk is an orally active Cysteine derivative. Leyk stimulates bone marrow hematopoiesis. Leyk exerts a significant protective effect against cyclophosphamide-induced leukopenia. Leyk can be used in studies related to thrombocytopenia and leukopenia.
    Leyk
  • HY-118078
    Robenacoxib 220991-32-2 98.08%
    Robenacoxib is a nonsteroidal anti-inflammatory and analgesic agent. Robenacoxib is a selective COX-2 inhibitor.
    Robenacoxib
  • HY-118368
    L-742001 hydrochloride 174605-64-2 99.9%
    L-742001 hydrochloride is an influenza virus PA endonuclease inhibitor, with an EC90 of 4.3 μM for vRNP activity in HEK293T cells.
    L-742001 hydrochloride
  • HY-118641
    Cannabinodiol 39624-81-2 99.90%
    Cannabinodiol, a cannabinoid analogue, is a phytocannabinoid.
    Cannabinodiol
製品番号 製品名 / Synonyms Application Reactivity