Leyk
Based on 1 Customer Validation
Leyk is an orally active Cysteine derivative. Leyk stimulates bone marrow hematopoiesis. Leyk exerts a significant protective effect against cyclophosphamide-induced leukopenia. Leyk can be used in studies related to thrombocytopenia and leukopenia.
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- Purity: 99.99%
- CAS No.: 1950-36-3
- 화학식: C14H17NO4S
- 분자량:295.35
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Immunology/Inflammation Compound Library
HY-L007
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Anti-Cardiovascular Disease Compound Library
HY-L046
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Orally Active Compound Library
HY-L061
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Anti-Hematopathy Compound Library
HY-L171
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ICR mice (male, 18-22 g, cyclophosphamide-induced)[3]
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Dosage:20 mg/kg
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Administration:p.o.; daily; 1 week
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Result:Restored the percentage of eosinophils to normal levels.
Increased the percentage of basophils.
Increased peripheral white blood cell counts.
Increased peripheral platelet counts.
Increased bone marrow nuclear cell counts.
Enhanced bone marrow nuclear cell viability.
Promoted bone marrow mononuclear cell colony formation.
Reversed cyclophosphamide-induced elevated serum G-CSF and IL-6 levels to near-normal values.
Exhibited a network analysis Z-score of 10.823, indicating significant anti-leucopenia activity.
Chemical Information
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CAS No. 1950-36-3
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Appearance Solid
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분자량 295.35
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화학식 C14H17NO4S
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Color White to off-white
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SMILES
O=C(C1NC(C(C2=CC=CC=C2)C(OCC)=O)SC1)O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 100 mg/mL (338.58 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (277 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Portuguese - PT (392 KB)
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Handling Instructions (2659 KB)
References
[1]. Su M, et al. The therapeutic effect of leucogen in treating alcoholic liver cirrhosis with thrombocytopenia or leukopenia. Ann Saudi Med. 2025;45(1):9-17. [Content Brief]
[2]. Huang XE, et al. Leucogen tablets at 60 mg three times per day are safe and effective to control febrile neutropenia. Asian Pac J Cancer Prev. 2014;15(19):8495-8497. [Content Brief]
[3]. Tian S, et al. Systems Biology Analysis of the Effect and Mechanism of Qi-Jing-Sheng-Bai Granule on Leucopenia in Mice. Front Pharmacol. 2019 Apr 25;10:408. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3858 mL | 16.9291 mL | 33.8581 mL | 84.6453 mL |
| 5 mM | 0.6772 mL | 3.3858 mL | 6.7716 mL | 16.9291 mL | |
| 10 mM | 0.3386 mL | 1.6929 mL | 3.3858 mL | 8.4645 mL | |
| 15 mM | 0.2257 mL | 1.1286 mL | 2.2572 mL | 5.6430 mL | |
| 20 mM | 0.1693 mL | 0.8465 mL | 1.6929 mL | 4.2323 mL | |
| 25 mM | 0.1354 mL | 0.6772 mL | 1.3543 mL | 3.3858 mL | |
| 30 mM | 0.1129 mL | 0.5643 mL | 1.1286 mL | 2.8215 mL | |
| 40 mM | 0.0846 mL | 0.4232 mL | 0.8465 mL | 2.1161 mL | |
| 50 mM | 0.0677 mL | 0.3386 mL | 0.6772 mL | 1.6929 mL | |
| 60 mM | 0.0564 mL | 0.2822 mL | 0.5643 mL | 1.4108 mL | |
| 80 mM | 0.0423 mL | 0.2116 mL | 0.4232 mL | 1.0581 mL | |
| 100 mM | 0.0339 mL | 0.1693 mL | 0.3386 mL | 0.8465 mL |
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