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  4. Leyk

Leyk is an orally active Cysteine derivative. Leyk stimulates bone marrow hematopoiesis. Leyk exerts a significant protective effect against cyclophosphamide-induced leukopenia. Leyk can be used in studies related to thrombocytopenia and leukopenia.

For research use only. We do not sell to patients.

Leyk

Leyk Chemical Structure

CAS No. : 1950-36-3

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Description

Leyk is an orally active Cysteine derivative. Leyk stimulates bone marrow hematopoiesis. Leyk exerts a significant protective effect against cyclophosphamide-induced leukopenia. Leyk can be used in studies related to thrombocytopenia and leukopenia[1][2][3].

In Vivo

Leucogen (20 mg/kg; p.o.; daily; 1 week) exerts significant protective effects against cyclophosphamide-induced leucopenia in male ICR mice, with a network analysis Z-score of 10.823, and restores hematopoietic parameters including white blood cell counts, platelet counts, bone marrow cell viability, and colony formation, while normalizing cytokine levels and white blood cell differential percentages[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR mice (male, 18-22 g, cyclophosphamide-induced)[3]
Dosage: 20 mg/kg
Administration: p.o.; daily; 1 week
Result: Restored the percentage of eosinophils to normal levels.
Increased the percentage of basophils.
Increased peripheral white blood cell counts.
Increased peripheral platelet counts.
Increased bone marrow nuclear cell counts.
Enhanced bone marrow nuclear cell viability.
Promoted bone marrow mononuclear cell colony formation.
Reversed cyclophosphamide-induced elevated serum G-CSF and IL-6 levels to near-normal values.
Exhibited a network analysis Z-score of 10.823, indicating significant anti-leucopenia activity.
Molecular Weight

295.35

Formula

C14H17NO4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1NC(C(C2=CC=CC=C2)C(OCC)=O)SC1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (338.58 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3858 mL 16.9291 mL 33.8581 mL
5 mM 0.6772 mL 3.3858 mL 6.7716 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.99%

SDS (392 KB)

COA (254 KB) HNMR (140 KB) RP-HPLC (208 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3858 mL 16.9291 mL 33.8581 mL 84.6453 mL
5 mM 0.6772 mL 3.3858 mL 6.7716 mL 16.9291 mL
10 mM 0.3386 mL 1.6929 mL 3.3858 mL 8.4645 mL
15 mM 0.2257 mL 1.1286 mL 2.2572 mL 5.6430 mL
20 mM 0.1693 mL 0.8465 mL 1.6929 mL 4.2323 mL
25 mM 0.1354 mL 0.6772 mL 1.3543 mL 3.3858 mL
30 mM 0.1129 mL 0.5643 mL 1.1286 mL 2.8215 mL
40 mM 0.0846 mL 0.4232 mL 0.8465 mL 2.1161 mL
50 mM 0.0677 mL 0.3386 mL 0.6772 mL 1.6929 mL
60 mM 0.0564 mL 0.2822 mL 0.5643 mL 1.4108 mL
80 mM 0.0423 mL 0.2116 mL 0.4232 mL 1.0581 mL
100 mM 0.0339 mL 0.1693 mL 0.3386 mL 0.8465 mL
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Leyk Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Leyk1950-36-3Drug DerivativeDrug derivativefebrile neutropeniathrombocytopenialung cancerleukocyte proliferationbone marrow hematopoiesisgastric cancernon-hodgkin’s lymphomaalcoholic liver cirrhosiscyclophosphamide-induced leukopenia modelsleukopeniaInhibitorinhibitorinhibit

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