2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

Related Products

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-136587
    Oxomemazine 3689-50-7 99.18%
    Oxomemazine is a phenothiazine-based histamine H1-receptor blocker. Oxomemazine is a selective antagonist for muscarinic M1 receptor, displays about 20-fold difference in the affinity for high (Ki = 84 nM, M1 receptor) and low (Ki = 1.65 μM, M2 receptor) affinity sites. Oxomemazine is an antihistamine and anticholinergic agent used for the study of cough treatment. Oxomemazine is protective against anaphylactic microshock in guinea pigs.
    Oxomemazine
  • HY-136592
    1-Hydroxy-ibuprofen 53949-53-4 98%
    1-Hydroxy Ibuprofen is a metabolite of Ibuprofen in P. australis. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively.
    1-Hydroxy-ibuprofen
  • HY-13662S
    Lansoprazole-d4 934294-22-1 99.82%
    Lansoprazole-d4 (AG-1749-d4) is a deuterium labeled Lansoprazole. Lansoprazole is a proton pump inhibitor which prevents the stomach from producing acid.
    Lansoprazole-d4
  • HY-136903
    SNJ-1945 854402-59-8 98%
    SNJ-1945 is an orally active Calpain inhibitor that can cross the blood-brain barrier. SNJ-1945 protects rat hearts against cardiac arrest-reperfusion injury by inhibiting the hydrolysis of α-fodrin. SNJ-1945 inhibits VEGF-induced angiogenesis in retinal endothelial cells. SNJ-1945 also protects SH-SY5Y cells from damage induced by MPP+ (HY-W008719) and Rotenone (HY-B1756). SNJ-1945 exhibits anti-inflammatory and neuroprotective activities in a mouse model of multiple sclerosis. SNJ-1945 can be used for the research of cardiovascular, nervous system and inflammatory diseases.
    SNJ-1945
  • HY-13693R
    Mometasone furoate (Standard) 83919-23-7 99.91%
    Mometasone furoate (Standard) is the analytical standard of Mometasone furoate. This product is intended for research and analytical applications. Mometasone furoate (Sch32088) is a glucocorticoid receptor agonist with anti-inflammatory and anti-allergic activity. Mometasone furoate acts as a corticosteroid agent and used for topical applications in chronic skin eczema and airway inflammation management of asthma in vivo
    Mometasone furoate (Standard)
  • HY-13723A
    Pimecrolimus hydrate 1000802-56-1 ≥98.0%
    Pimecrolimus hydrate (SDZ-ASM 981 hydrate) is a potent, nonsteroid and orally active calcineurin inhibitor. Pimecrolimus hydrate shows anti-inflammatory activity. Pimecrolimus hydrate has the potential for the research of atopic dermatitis and oral erosive lichen planus.
    Pimecrolimus hydrate
  • HY-137394
    Nicotredole 29876-14-0 99.87%
    Nicotredole (Tryptamide) is an orally active anti-inflammatory and analgesic agent. Nicotredole exhibits evident antiinflammatory effects of potency comparable with Phenylbutazone. Nicotredole has only weak ulcerogenic activity.
    Nicotredole
  • HY-137572
    (R)-DOI hydrochloride 82864-02-6 99.63%
    (R)-DOI hydrochloride is a selective 5HT2A receptor agonist. (R)-DOI hydrochloride has anti-inflammatory, anti-oxidative stress, and lysosomal function-improving effects. (R)-DOI hydrochloride can be used for the researches of inflammation and neurological disease, such as Alzheimer's disease.
    (R)-DOI hydrochloride
  • HY-137960
    O,O-Dimethyl-cannabigerol 29106-16-9 99.86%
    O,O-Dimethyl-cannabigerol is a natural product from Cannabis sativa. O,O-Dimethyl-cannabigerol has an antibacterial effect on drug-resistant strains of Staphylococcus aureus (MIC ranging from 1 to 2 μg/mL). O,O-Dimethyl-cannabigerol is a nonpsychoactive constituent.
    O,O-Dimethyl-cannabigerol
  • HY-138148
    13(S)-HPOTrE(γ) 121107-97-9 99.9%
    13(S)-HpOTrE(γ) is a monohydroxy PUFA produced by the action of soybean lipoxygenase-1 (LO-1) on γ-linolenic acid. Further action of soybean LO-1 converts 13(S)-HpOTrE(γ) to all four isomers of 6,13-DiHOTrE.2 At concentrations greater than 100 μM, 13(S)-HpOTrE(γ) inhibits the activity of soybean LO-1.
    13(S)-HPOTrE(γ)
  • HY-138202
    Lck-IN-1 923596-52-5 98.54%
    Lck-IN-1 is a potent lymphocyte protein tyrosine kinase (Lck) inhibitor extracted from patent WO2007013673A1, example 48.
    Lck-IN-1
  • HY-138305
    HCV-IN-31 1998705-62-6 99.69%
    HCV-IN-31 (compound 4) is a HCV inhibitor, with an EC50/EC95 of 15.7 μM for HCV replicon.
    HCV-IN-31
  • HY-138961
    ER-27319 201010-95-9 98.66%
    ER-27319, an acridone derivative, is a potent and selective SYK inhibitor, and inhibits the tyrosine phosphorylation of SYK and its activity. ER-27319 inhibits the release of antigen-induced allergic mediators from human and rat mast cells with an IC50 of 10 μM and can be used for study in allergic diseases.
    ER-27319
  • HY-139055
    NCTT-956 438575-88-3
    NCTT-956 is a very effective platelet 12-lipoxygenase (12-LOX) activity-specific inhibitor.
    NCTT-956
  • HY-139205
    BMT-297376 2251031-81-7 99.14%
    BMT-297376 is an optimized derivative of Linrodostat (HY-101560). BMT-297376 inhibits IDO1 and the ubiquinone (Q) site of mitochondrial respiratory chain complex I. BMT-297376 is suitable for tumor immunology-related research.
    BMT-297376
  • HY-139207
    Glucosamine sulfate potassium chloride 1296149-08-0 98%
    Glucosamine sulfate potassium chloride is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine sulfate potassium chloride also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes.
    Glucosamine sulfate potassium chloride
  • HY-139331
    20S Proteasome-IN-1 858557-69-4 99.13%
    20S Proteasome-IN-1 is a 26S proteasome inhibitor extracted from patent WO2006128196A2 compound 2. 20S Proteasome-IN-1 has the potential for cancer, immune-related disorders, inflammation, ischemic conditions, neurodegenerative disorders and other diseases research.
    20S Proteasome-IN-1
  • HY-139570
    Ecubectedin 2248127-53-7 99.59%
    Ecubectedin (PM14) is a derivative. Ecteinascidins is a family of tetrahydroisoquinoline alkaloids with wide range of antitumor and antimicrobial activities.
    Ecubectedin
  • HY-139684
    MNK1/2-IN-5 1426928-20-2 99.93%
    MNK1/2-IN-5 is a potent and selective MNK1/2 inhibitor as a therapeutic agent.
    MNK1/2-IN-5
  • HY-139807
    JAK-IN-14 1973485-06-1 99.15%
    JAK-IN-14 is a potent and selective JAK1 inhibitor, with an IC50 of <5 μM. JAK-IN-14 is >8-fold more selective for JAK1 than JAK2 and JAK3 (Patent WO2016119700A1, compound 16).
    JAK-IN-14
Cat. No. Product Name / Synonyms Application Reactivity