(R)-DOI hydrochloride

Name: (R)-DOI hydrochloride
Brand: MedChemExpress
SKU: HY-137572
Rating: 4.5 (1 reviews)

Cat. No.: HY-137572 Purity: 99.63%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

(R)-DOI hydrochloride is a selective 5HT2A receptor agonist. (R)-DOI hydrochloride has anti-inflammatory, anti-oxidative stress, and lysosomal function-improving effects. (R)-DOI hydrochloride can be used for the researches of inflammation and neurological disease, such as Alzheimer's disease.

For research use only. We do not sell to patients.

(R)-DOI hydrochloride Chemical Structure

CAS No. : 82864-02-6

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of (R)-DOI hydrochloride:

DOI hydrochloride In-stock

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View All Isoforms

5-HT Receptor 5-HT₁ Receptor 5-HT₂ Receptor 5-HT₃ Receptor 5-HT₄ Receptor 5-HT₅ Receptor 5-HT₆ Receptor 5-HT₇ Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

5-HT_2A Receptor

Molecular Weight

357.62

Formula

C₁₁H₁₇ClINO₂

CAS No.

82864-02-6

Appearance

Solid

Color

White to off-white

SMILES

C[C@@H](N)CC1=C(C=C(C(OC)=C1)I)OC.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (279.63 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : ≥ 50 mg/mL (139.81 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7963 mL	13.9813 mL	27.9626 mL
5 mM	0.5593 mL	2.7963 mL	5.5925 mL
10 mM	0.2796 mL	1.3981 mL	2.7963 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.63%

Select Batch:

Data Sheet (272 KB) SDS (252 KB)

COA (251 KB) HNMR (247 KB) LCMS (329 KB)

Handling Instructions (2659 KB)

References

[1]. Timothy P. FOSTER, et al. Compositions and methods of use thereof. WO2024191924A2. 2025-09-10

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	2.7963 mL	13.9813 mL	27.9626 mL	69.9066 mL
	5 mM	0.5593 mL	2.7963 mL	5.5925 mL	13.9813 mL
	10 mM	0.2796 mL	1.3981 mL	2.7963 mL	6.9907 mL
	15 mM	0.1864 mL	0.9321 mL	1.8642 mL	4.6604 mL
	20 mM	0.1398 mL	0.6991 mL	1.3981 mL	3.4953 mL
	25 mM	0.1119 mL	0.5593 mL	1.1185 mL	2.7963 mL
	30 mM	0.0932 mL	0.4660 mL	0.9321 mL	2.3302 mL
	40 mM	0.0699 mL	0.3495 mL	0.6991 mL	1.7477 mL
	50 mM	0.0559 mL	0.2796 mL	0.5593 mL	1.3981 mL
	60 mM	0.0466 mL	0.2330 mL	0.4660 mL	1.1651 mL
	80 mM	0.0350 mL	0.1748 mL	0.3495 mL	0.8738 mL
	100 mM	0.0280 mL	0.1398 mL	0.2796 mL	0.6991 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.