SRT 2104

Name: SRT 2104
Brand: MedChemExpress
SKU: HY-15262
Rating: 5.0 (22 reviews)

Cat. No.: HY-15262 Purity: 99.27%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

SRT 2104 is a first-in-class, highly selective and brain-permeable activator of the NAD⁺ dependent deacetylase Sirt1, increases Sirt1 protein, but shows no effect on Sirt1 mRNA. Used in the research of diabetes mellitus and Huntington’s disease.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No. : 1093403-33-8

사이즈	재고	수량
무료 샘플 (0.1 - 0.2 mg)	지금 신청하기
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	해외재고보유	Estimated Time of Arrival: December 31
500 mg	해외재고보유	Estimated Time of Arrival: December 31
1 g	견적 받기
5 g	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 22 publication(s) in Google Scholar

22 Publications Citing Use of MCE SRT 2104

Cell Proliferation/Viability Assay

In Vivo Efficacy Study

RT-PCR

IHC

: SRT 2104 purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Sep 26:e10103. [Abstract]; ATDC5 cells were treated with different concentrations of SRT2104 (SRT; 0, 0.5, 1 μM), a specific Sirt1 activator, for 48 h, reduced the acetylation of Piezo1.

: SRT 2104 purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Sep 26:e10103. [Abstract]; After SRT2104 (SRT; 0, 0.25, 0.5, 1, 2 μM) intervention in ATDC5 cells for 48 h, western blotting was used to detect the expression of Piezo1 protein in the cells.

: SRT 2104 purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2025 Sep:190:118391. [Abstract]; Cells were treated with SRT2104 at the concentration of 5 and 12.5 µM for 96 h.

: SRT 2104 purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2025 Sep:190:118391. [Abstract]; Lung cancer cell lines were treated with calcitriol (10 nM for EGFR mutant cells and HSAEC or 100 nM for other cell lines) and SRT2104 (5 µM) for 72 h. Representative blots of VDR, CYP24 A1 and SIRT1.

: SRT 2104 purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2025 Sep:190:118391. [Abstract]; Lung cancer cell lines were treated with calcitriol (10 nM for EGFR mutant cells and HSAEC or 100 nM for other cell lines) and SRT2104 (5 µM) for 72 h. Relative CYP24 A1 mRNA expression determined by RT-qPCR.

: SRT 2104 purchased from MedChemExpress. Usage Cited in: Neural Regen Res. 2021 Dec;16(12):2465-2474.; SRT2104 (10 μM) was intracerebroventricularly injected into six diabetic model rats for 16 days, increasing SIRT1, TORC1, p-CREB, and BDNF levels in the hippocampus.

: SRT 2104 purchased from MedChemExpress. Usage Cited in: Neural Regen Res. 2021 Dec;16(12):2465-2474.; SRT2104 (10 μM) was intracerebroventricularly injected into six diabetic model rats for 16 days, significantly increasing the dendritic lengths and spine densities in the hippocampus of diabetic model rats.

: SRT 2104 purchased from MedChemExpress. Usage Cited in: Cartilage. 2020 Jan 28;1947603519900795. [Abstract]; Safranin O-fast green staining of the medial knee joint at 4, 8, 12, and 16 weeks postsurgery. Scale bar = 100 μm.

: SRT 2104 purchased from MedChemExpress. Usage Cited in: J Mol Med (Berl). 2018 Sep;96(9):939-949. [Abstract]; To test the effect of miR-34a inhibition and SIRT1 activation on the expression of miR-34a and Sirt1, the diabetic mice are treated with NC-I, miR-34a-I or SRT2104. Sirt1 mRNA levels are determined by qPCR.

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View All Sirtuin Isoform Specific Products:

View All Isoforms

Sirtuin SIRT1 SIRT2 SIRT3 SIRT6 SIRT5 SIRT7 SIRT4

Biological Activity
순도&문서
References
고객리뷰

제품 설명

IC₅₀ & Target^[1]

SIRT1

In Vivo

SRT 2104 (100 mg/kg/day, supplemented in diet for 24 weeks) increases SIRT1 protein without altering Sirt1 mRNA in diabetic mice^[2].
SRT 2104 (100 mg/kg/day, supplemented in diet for 24 weeks) decreases testicular oxidative stress, activation of apoptotic signaling, and ER stress in diabetic mice^[2].
SRT 2104 (0.5% in diet; p.o.; for 18 weeks) improves motor function and increases survival in N171-82Q HD mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male C57BL/6 mice (8-week-old)^[2]
Dosage:	100 mg/kg/day
Administration:	Supplemented in diet for 24 weeks
Result:	Enhanced SIRT1 protein without evelating Sirt1 mRNA level. Attenuated diabetes mellitus (DM)-induced oxidative stress, apoptotic signaling, and ER stress.

Animal Model:	WT and N171-82Q HD mice (6 weeks old)^[3]
Dosage:	0.5%
Administration:	0.5% SRT 2104 containing diet for 6, 12, 18 weeks
Result:	Ameliorated motor deficits and increased survival in N171-82Q HD mice.

Clinical Trial

분자량

516.64

화학식

C₂₆H₂₄N₆O₂S₂

CAS No.

1093403-33-8

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=C(C)N=C(C2=CC=CN=C2)S1)NC3=CC=CC=C3C4=CN5C(SC=C5CN6CCOCC6)=N4

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	1 year
	-20°C	6 months

용액&용해도

In Vitro:

DMSO : 5 mg/mL (9.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9356 mL	9.6779 mL	19.3558 mL
5 mM	0.3871 mL	1.9356 mL	3.8712 mL
10 mM	---	---	---

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 0.5 mg/mL (0.97 mM); Clear solution

This protocol yields a clear solution of ≥ 0.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (5.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 0.5 mg/mL (0.97 mM); Clear solution

This protocol yields a clear solution of ≥ 0.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (5.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

순도&문서

Purity: 99.27%

Select Batch:

Data Sheet (281 KB) SDS (396 KB)

COA (259 KB) HNMR (282 KB) RP-HPLC (256 KB) MS (88 KB)

Handling Instructions (2659 KB)

References

[1]. Hoffmann E, et al. Pharmacokinetics and tolerability of SRT2104, a first-in-class small molecule activator of SIRT1, after single and repeated oral administration in man. [Content Brief]

[2]. Jiao D, et al. MicroRNA-34a targets sirtuin 1 and leads to diabetes-induced testicular apoptotic cell death. J Mol Med (Berl). 2018 Sep;96(9):939-949. [Content Brief]

[3]. Jiang M, et al. Sirtuin 1 activator SRT2104 protects Huntington's disease mice. Ann Clin Transl Neurol. 2014 Dec;1(12):1047-52. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9356 mL	9.6779 mL	19.3558 mL	48.3896 mL
DMSO	5 mM	0.3871 mL	1.9356 mL	3.8712 mL	9.6779 mL

SRT 2104 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SRT 21041093403-33-8SRT2104SRT-2104SirtuinInhibitorinhibitorinhibit

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SRT 2104

고객리뷰

SRT 2104 Related Antibodies

22 Publications Citing Use of MCE SRT 2104

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Sirtuin Isoform Specific Products:

Biological Activity

순도&문서

References

고객리뷰

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

SRT 2104 Related Classifications

Keywords:

최근 본 상품:

고객리뷰

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report