2. Cell Cycle/DNA Damage Epigenetics
  3. Sirtuin
  4. SRT 2104

SRT 2104 is a first-in-class, highly selective and brain-permeable activator of the NAD+ dependent deacetylase Sirt1, increases Sirt1 protein, but shows no effect on Sirt1 mRNA. Used in the research of diabetes mellitus and Huntington’s disease.

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CAS 番号 : 1093403-33-8

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
5 mg $110 在庫あり
10 mg $165 在庫あり
25 mg $330 在庫あり
50 mg $495 在庫あり
100 mg $715 在庫あり
200 mg $1155 在庫あり
500 mg $2145 在庫あり
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カスタマーレビュー

Based on 22 publication(s) in Google Scholar

SRT 2104 関連抗体

Top Publications Citing Use of Products

    SRT 2104 purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Sep 26:e10103.  [Abstract]

    ATDC5 cells were treated with different concentrations of SRT2104 (SRT; 0, 0.5, 1 μM), a specific Sirt1 activator, for 48 h, reduced the acetylation of Piezo1.

    SRT 2104 purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Sep 26:e10103.  [Abstract]

    After SRT2104 (SRT; 0, 0.25, 0.5, 1, 2 μM) intervention in ATDC5 cells for 48 h, western blotting was used to detect the expression of Piezo1 protein in the cells.

    SRT 2104 purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2025 Sep:190:118391.  [Abstract]

    Cells were treated with SRT2104 at the concentration of 5 and 12.5 µM for 96 h.

    SRT 2104 purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2025 Sep:190:118391.  [Abstract]

    Lung cancer cell lines were treated with calcitriol (10 nM for EGFR mutant cells and HSAEC or 100 nM for other cell lines) and SRT2104 (5 µM) for 72 h. Representative blots of VDR, CYP24 A1 and SIRT1.

    SRT 2104 purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2025 Sep:190:118391.  [Abstract]

    Lung cancer cell lines were treated with calcitriol (10 nM for EGFR mutant cells and HSAEC or 100 nM for other cell lines) and SRT2104 (5 µM) for 72 h. Relative CYP24 A1 mRNA expression determined by RT-qPCR.

    SRT 2104 purchased from MedChemExpress. Usage Cited in: Neural Regen Res. 2021 Dec;16(12):2465-2474.

    SRT2104 (10 μM) was intracerebroventricularly injected into six diabetic model rats for 16 days, increasing SIRT1, TORC1, p-CREB, and BDNF levels in the hippocampus.

    SRT 2104 purchased from MedChemExpress. Usage Cited in: Neural Regen Res. 2021 Dec;16(12):2465-2474.

    SRT2104 (10 μM) was intracerebroventricularly injected into six diabetic model rats for 16 days, significantly increasing the dendritic lengths and spine densities in the hippocampus of diabetic model rats.

    SRT 2104 purchased from MedChemExpress. Usage Cited in: Cartilage. 2020 Jan 28;1947603519900795.  [Abstract]

    Safranin O-fast green staining of the medial knee joint at 4, 8, 12, and 16 weeks postsurgery. Scale bar = 100 μm.

    SRT 2104 purchased from MedChemExpress. Usage Cited in: J Mol Med (Berl). 2018 Sep;96(9):939-949.  [Abstract]

    To test the effect of miR-34a inhibition and SIRT1 activation on the expression of miR-34a and Sirt1, the diabetic mice are treated with NC-I, miR-34a-I or SRT2104. Sirt1 mRNA levels are determined by qPCR.

    Sirtuin アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Sirtuin SIRT1 SIRT2 SIRT3 SIRT6 SIRT5 SIRT7 SIRT4

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

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    製品説明

    SRT 2104 is a first-in-class, highly selective and brain-permeable activator of the NAD+ dependent deacetylase Sirt1, increases Sirt1 protein, but shows no effect on Sirt1 mRNA. Used in the research of diabetes mellitus and Huntington’s disease[1][2][3].

    IC50 & Target[1]

    SIRT1

     

    体内実験

    SRT 2104 (100 mg/kg/day, supplemented in diet for 24 weeks) increases SIRT1 protein without altering Sirt1 mRNA in diabetic mice[2].
    SRT 2104 (100 mg/kg/day, supplemented in diet for 24 weeks) decreases testicular oxidative stress, activation of apoptotic signaling, and ER stress in diabetic mice[2].
    SRT 2104 (0.5% in diet; p.o.; for 18 weeks) improves motor function and increases survival in N171-82Q HD mice[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male C57BL/6 mice (8-week-old)[2]
    Dosage: 100 mg/kg/day
    Administration: Supplemented in diet for 24 weeks
    Result: Enhanced SIRT1 protein without evelating Sirt1 mRNA level. Attenuated diabetes mellitus (DM)-induced oxidative stress, apoptotic signaling, and ER stress.
    Animal Model: WT and N171-82Q HD mice (6 weeks old)[3]
    Dosage: 0.5%
    Administration: 0.5% SRT 2104 containing diet for 6, 12, 18 weeks
    Result: Ameliorated motor deficits and increased survival in N171-82Q HD mice.
    臨床実験
    分子量

    516.64

    分子式

    C26H24N6O2S2
    CAS 番号
    Appearance

    Solid

    Color

    Light yellow to yellow

    SMILES

    O=C(C1=C(C)N=C(C2=CC=CN=C2)S1)NC3=CC=CC=C3C4=CN5C(SC=C5CN6CCOCC6)=N4
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    溶剤 & 溶解度
    体外: 

    DMSO : 5 mg/mL (9.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.9356 mL 9.6779 mL 19.3558 mL
    5 mM 0.3871 mL 1.9356 mL 3.8712 mL
    10 mM --- --- ---
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
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    Volume
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

    V1

    =
    濃度 （終了）

    C2

    ×
    体積 （終了）

    V2

    体内:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 0.5 mg/mL (0.97 mM); Clear solution

      This protocol yields a clear solution of ≥ 0.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (5.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 0.5 mg/mL (0.97 mM); Clear solution

      This protocol yields a clear solution of ≥ 0.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (5.0 mg/mL) to 900 μL Corn oil, and mix evenly.

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

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    (per animal)

    g

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    純度とドキュメンテーション

    純度: 99.27%

    COA (259 KB) HNMR (282 KB) RP-HPLC (256 KB) MS (88 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.9356 mL 9.6779 mL 19.3558 mL 48.3896 mL
    5 mM 0.3871 mL 1.9356 mL 3.8712 mL 9.6779 mL
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    SRT 2104 Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    SRT 21041093403-33-8SRT2104SRT-2104SirtuinInhibitorinhibitorinhibit

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    製品名:
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    製品番号:
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