2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor 5-HT Receptor
  4. TDHL

TDHL  (Synonyms: Tergurid; Terguride; trans-Dihydrolisuride)

製品番号: HY-12714 純度: 99.9%
COA 取扱説明書 Technical Support

TDHL (Tergurid) is a dopamine receptor agonist with a Kd of 0.39 nM for D2 receptor and an orally available 5-HT-2 receptor antagonist.

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TDHL

TDHL 構造式

CAS 番号 : 37686-84-3

容量 価格（税別） 在庫状況 数量
1 mg $375 在庫あり
5 mg $937 在庫あり
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TDHL 関連抗体

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Dopamine Receptor アイソフォーム固有の製品をすべて表示:

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Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor

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製品説明

TDHL (Tergurid) is a dopamine receptor agonist with a Kd of 0.39 nM for D2 receptor and an orally available 5-HT-2 receptor antagonist.

IC50 & Target

Kd: 0.39 nM (Dopamine D2-receptor)[2], 5-HT2[1]
体外実験

Proliferation and migration of cultured primary human pulmonary artery smooth muscle cells (PASMC) were dose-dependently blocked by TDHL[1].Terguride is found to bind selectively to the pituitary dopamine D2-receptors with a high affinity (Kd=0.39 nM)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TDHL 関連抗体
体内実験

TDHL abolished 5-HT-induced pulmonary vasoconstriction. Chronic terguride treatment prevented dose-dependently the development and progression of MCT-induced PAH in rats[1]. In reserpinized rats, terguride at 0.03 mg/kg, p.o. significantly reduces the serum prolactin (PRL) level. In rats bearing estrogen-induced pituitary prolactinoma, chronic terguride induces shrinkage of the prolactinoma as well as reduction of the high serum PRL level. In lactating rats, terguride (1.0 mg/kg, s.c.) reduces milk production in the mammary gland[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

340.46

分子式

C20H28N4O
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

CN1[C@@]2([H])[C@@](C[C@@H](C1)NC(N(CC)CC)=O)([H])C3=CC=CC4=C3C(C2)=CN4
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
純度とドキュメンテーション

純度: 99.9%

COA (246 KB)

取扱説明書 (2659 KB)
参考文献
細胞実験
[1]

Freshly isolated human PASMCs are treated with TDHL or vehicle for 24 h. Then, [3H]thymidine is added to each well for 6 h. After ishing with PBS, cells are lysed in 0.5 M NaOH and [3H]thymidine incorporation is quantified[1].

MedChemExpress (MCE) はこれらの方法の精度を確認していません。 こちらは参照専用です。
動物実験
[1]

Rats[1]

Adult male Sprague Dawley rats (body weight 300–350 g) are used. For chronic treatment studies, seven groups with MCT-induced PH are studied. Rats are treated with TDHL (0.4, 1.2 mg/kg) for 0-28 days[1].

MedChemExpress (MCE) はこれらの方法の精度を確認していません。 こちらは参照専用です。
参考文献
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TDHL Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TDHL37686-84-3Tergurid Terguride trans-DihydrolisurideDopamine Receptor5-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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