2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Lipoxygenase

Lipoxygenase

LOX

Lipoxygenase

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Lipoxygenases (LOXs) are a family of enzymes that are responsible for the metabolism of arachidonic and docosahexaenoic acid and for the formation of several eicosanoids and docosanoids, including leukotrienes, lipoxins and neuroprotectins. Depending on cells' redox state and other milieu conditions, these enzymes are engaged in oxidative stress and cell death mechanisms or in cell protection. Lipoxygenases are lipid peroxidizing enzymes, implicated in the pathogenesis of inflammatory and hyperproliferative diseases, which represent potential targets for pharmacological intervention.

Lipoxygenases are classified on the basis of site of arachidonate oxygenation into 5-, 8-, 9-, 11-, 12- and 15-LOX. The prominent animal LOXs are 5-LOX, 8-LOX, 12-LOX and 15-LOX, while the plant LOXs are mostly 5-LOX and 15-LOX. Among these, 5-LOX is the most predominant isoform associated with the formation of 5-hydroperoxyeicosatetraenoic acid (5-HpETE) and other bioactive lipid mediators.

Lipoxygenase Isoform Specific Products:

Lipoxygenase Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-U00156
    Lonapalene
    		Inhibitor 99.07%
    Lonapalene (RS4317) is a topically effective 5-lipoxygenase (5-LO) inhibitor.
    Lonapalene
  • HY-U00022
    RWJ 63556
    		Inhibitor 99.35%
    RWJ 63556 is an orally active COX-2 selective/5-lipoxygenase inhibitor, with anti-inflammatory activities.
    RWJ 63556
  • HY-50672
    MK-0731
    		Inhibitor
    MK-0731 is a selective, non-competitive and allosteric kinesin spindle protein (KSP) inhibitor with an IC50 of 2.2 nM and a pKa of 7.6. MK-0731 is >20,000 fold selectivity against other kinesins. MK-0731 induces mitotic arrest and induces apoptosis in tumors. MK-0731 provides significant antitumor efficacy.
    MK-0731
  • HY-N9834
    Aureusidin
    		Inhibitor
    Aureusidin is an aurone with high antioxidant and lipoxygenase inhibitory activity. Aureusidin also shows anti-inflammatory effects.
    Aureusidin
  • HY-118480
    4-MMPB
    		Inhibitor 99.69%
    4-MMPB is a selective inhibitor of 15-lipoxygenase, with an IC50 of 18 μM. 4-MMPB has IC50s of 19.5 μM and 19.1 μM for soybean 15-lipoxygenase (SLO) and human 15-lipoxygenase-1 (15-LOX-1), respectively. 4-MMPB has potential for the research of prostate cancer.
    4-MMPB
  • HY-N7162
    3-O-Acetyl-11-hydroxy-beta-boswellic acid
    		Inhibitor 98.98%
    3-O-Acetyl-11-hydroxy-beta-boswellic acid is a potent 5-lipoxygenase (5-LO) inhibitor.
    3-O-Acetyl-11-hydroxy-beta-boswellic acid
  • HY-N2074
    Picrinine
    		Inhibitor 99.33%
    Picrinine, an akuammiline alkaloid, is isolated from the leaves of Alstonia scholaris. Picrinine exhibits anti-inflammatory activity through inhibition of the 5-lipoxygenase enzyme.
    Picrinine
  • HY-118110
    MLS000545091
    		Inhibitor 99.92%
    MLS000545091 is a potent and selective lipoxygenase-2 (LOX-2) inhibitor with an IC50 value of 2.6 μM for h15-LOX-2.
    MLS000545091
  • HY-N10898
    (-)-Dihydroguaiaretic acid
    		Inhibitor 98.79%
    (-)-Dihydroguaiaretic acid is a Lipoxygenase inhibitor that has antioxidant activity. (-)-Dihydroguaiaretic acid inhibits the oxidation of unsaturated fatty acids and removes free radicals. (-)-Dihydroguaiaretic acid also has anticancer activity with an IC50 value of 7.49 μM (A549 cells).
    (-)-Dihydroguaiaretic acid
  • HY-103158
    BW B70C
    		Inhibitor
    BW B70C is a potent, selective and orally activearachidonic acid 5-lipoxygenase inhibitor. BW B70C inhibits both acute and allergic bronchoconstriction and late-phase eosinophil accumulation subsequent to allergen inhalation in guinea-pigs. BW B70C prevents leukotriene C4 synthesis and reduces leucocyte migration to the airways lumen as well as albumin microvascular leakage. BW B70C has the potential for the research of anti-asthma agent.
    BW B70C
  • HY-N11058
    Damnacanthol
    		Inhibitor 99.76%
    Damnacanthol is a natural product that can be isolated from Damnacanthus major. Damnacanthol has anti-15-lipoxygenase activity and can inhibit nitric oxide production in LPS-activated macrophages RAW 264.7 cells.
    Damnacanthol
  • HY-W010144
    Phenidone
    		Inhibitor 99.00%
    Phenidone, an orally active dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), ameliorates rat paralysis in experimental autoimmune encephalomyelitis. Phenidone is a potent hypotensive agent in the spontaneously hypertensive rat. Phenidone is used as a photographic developer.
    Phenidone
  • HY-U00024
    Enazadrem
    		Inhibitor
    Enazadrem is a 5-lipoxygenase inhibitor with antiinflammatory activities.
    Enazadrem
  • HY-101587
    PGS-IN-1
    		Inhibitor 99.51%
    PGS-IN-1 is a potent inhibitor of prostaglandin synthetase (PGS) with an IC50 of 0.28 μM; also inhibits 5-lipoxygenase with an IC50 of 1.05 μM.
    PGS-IN-1
  • HY-124252
    5,8,11-Eicosatriynoic acid
    		Inhibitor
    5,8,11-Eicosatriynoic acid (ETI) is a lipoxygenase inhibitor that blocks LTC4 biosynthesis in mast cell tumor cells.
    5,8,11-Eicosatriynoic acid
  • HY-112553
    HZ52
    		Inhibitor
    HZ52 is a potent, reversible 5-lipoxygenase inhibitor, blocking leukotriene synthesis with an IC50 of 0.7 μM in intact human polymorphonuclear leukocytes.
    HZ52
  • HY-N10020
    Patulitrin
    		Inhibitor
    Patulitrin has scavenging effect in the DPPH radical. Patulitrin inhibits soybean lipoxygenase. Patulitrin also has antihypertensive effect. Patulitrin is an antioxidant flavonoid that can be isolated from Anthemis tinctoria.
    Patulitrin
  • HY-158204
    CNB-001
    		Inhibitor
    CNB-001 is a potent 5-lipoxygenase (5-LOX) inhibitor, decreases 5-LOX expression, and increases proteasome activity. CNB-001 also increases eIF2α phosphorylation and HSP90 and ATF4 levels in Alzheimer's disease transgenic mice, and limits the accumulation of soluble Aβ and ubiquitinated aggregated proteins. CNB-001 maintains the expression of synapse-associated proteins and improves memory. CNB-001 can be used for the research of Alzheimer's disease.
    CNB-001
  • HY-116638
    AHR-5333
    		Inhibitor
    AHR-5333 is a selective human blood neutrophil 5-lipoxygenase inhibitor. AHR-5333 exhibits potent, long-acting activity in rat and guinea pig in vivo models of immediate hypersensitivity.
    AHR-5333
  • HY-14164R
    Zileuton (Standard)
    		Inhibitor
    Zileuton (Standard) is the analytical standard of Zileuton. This product is intended for research and analytical applications. Zileuton is a potent and selective inhibitor of 5-lipoxygenase with antiasthmatic properties.
    Zileuton (Standard)
Cat. No. Product Name / Synonyms Application Reactivity
Lipoxygenase Isoform Comparison

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