1. Metabolic Enzyme/Protease
    Apoptosis
  2. Lipoxygenase
    Apoptosis
  3. 4-MMPB

4-MMPB 

Cat. No.: HY-118480 Purity: 98.31%
Handling Instructions

4-MMPB is a selective inhibitor of 15-lipoxygenase, with an IC50 of 18 μM. 4-MMPB has IC50s of 19.5 μM and 19.1 μM for soybean 15-lipoxygenase (SLO) and human 15-lipoxygenase-1 (15-LOX-1), respectively. 4-MMPB has potential for the research of prostate cancer.

For research use only. We do not sell to patients.

4-MMPB Chemical Structure

4-MMPB Chemical Structure

CAS No. : 928853-86-5

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 275 In-stock
Estimated Time of Arrival: December 31
5 mg USD 250 In-stock
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10 mg USD 450 In-stock
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25 mg USD 950 In-stock
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50 mg USD 1650 In-stock
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100 mg USD 2550 In-stock
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Description

4-MMPB is a selective inhibitor of 15-lipoxygenase, with an IC50 of 18 μM. 4-MMPB has IC50s of 19.5 μM and 19.1 μM for soybean 15-lipoxygenase (SLO) and human 15-lipoxygenase-1 (15-LOX-1), respectively. 4-MMPB has potential for the research of prostate cancer[1][2][3][4].

IC50 & Target

IC50: 18 μM (15-lipoxygenase)[1]

In Vitro

4-MMPB has an IC50 of 69.6 μM for DPPH bleaching[2].
4-MMPB exhibits cytotoxic activity on human PC-3 and HFF3 cell lines[4].
4-MMPB (41.48 µM; 72 hours) induces apoptosis and DNA damage in PC-3 Cells[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[4]

Cell Line: DU145 cells, PC-3 cells, HFF3 cells
Concentration: 9.57 µM, 19.94 µM, 39.88 µM, 79.77 µM,159.53 µM
Incubation Time: 24 hours, 48 hours, 72 hours
Result: IC50s of 79.76 µM (24 hours), 51.05 µM (48 hours) and 41.48 µM (72 hours) for PC-3 cells, and 255.25 µM (24 hours), 130.81 µM (48 hours) and 98.91 µM (72 hours) for HFF3 cells.
Molecular Weight

313.42

Formula

C₁₆H₁₉N₅S

CAS No.

928853-86-5

SMILES

CC1=C2NC3=C(SC2=NC(N4CCN(CC4)C)=N1)C=CC=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 7.69 mg/mL (24.54 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1906 mL 15.9530 mL 31.9061 mL
5 mM 0.6381 mL 3.1906 mL 6.3812 mL
10 mM 0.3191 mL 1.5953 mL 3.1906 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.77 mg/mL (2.46 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 0.77 mg/mL (2.46 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 0.77 mg/mL (2.46 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

4-MMPBLipoxygenaseApoptosisLOXradicalscavenginglipoxygenaseinhibitioncancerInhibitorinhibitorinhibit

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Product Name:
4-MMPB
Cat. No.:
HY-118480
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