928853-86-5
928853-86-5
Chemical Structure
4-MMPB
- CAS No.: 928853-86-5
- Formula:C16H19N5S
- Molecular Weight:313.42
IUPAC Name: 4-methyl-2-(4-methylpiperazin-1-yl)-5H-benzo[b]pyrimido[5,4-e][1,4]thiazine
InChIKey: HYPHGMNLWIKEMB-UHFFFAOYSA-N
SMILES: CC1=C2NC3=C(SC2=NC(N4CCN(CC4)C)=N1)C=CC=C3
Biological Activity: 4-MMPB is a selective inhibitor of 15-lipoxygenase, with an IC50 of 18 μM. 4-MMPB has IC50s of 19.5 μM and 19.1 μM for soybean 15-lipoxygenase (SLO) and human 15-lipoxygenase-1 (15-LOX-1), respectively. 4-MMPB has potential for the research of prostate cancer[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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4-MMPB | 98.54% | 4-MMPB is a selective inhibitor of 15-lipoxygenase, with an IC50 of 18 μM. 4-MMPB has IC50s of 19.5 μM and 19.1 μM for soybean 15-lipoxygenase (SLO) and human 15-lipoxygenase-1 (15-LOX-1), respectively. 4-MMPB has potential for the research of prostate cancer. | ||||||||||||||||||||
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References
- [1]. M Bakavoli, et al. Design and synthesis of pyrimido[4,5-b][1,4]benzothiazine derivatives, as potent 15-lipoxygenase inhibitors. Bioorg Med Chem. 2007 Mar 1;15(5):2120-6. [Content Brief]
- [2]. Mohsen Nikpour, et al. Synthesis of new series of pyrimido[4,5-b][1,4] benzothiazines as 15-lipoxygenase inhibitors and study of their inhibitory mechanism. 2013, 22(10), 5036-5043.
- [3]. Seyed Jamal Alavi, et al. A novel class of human 15-LOX-1 inhibitors based on 3-hydroxycoumarin. Chem Biol Drug Des. 2018 Jun;91(6):1125-1132. [Content Brief]
- [4]. Saffiyeh Saboormaleki, et al. 7-Farnesyloxycoumarin Exerts Anti-cancer Effects on a Prostate Cancer Cell Line by 15-LOX-1 Inhibition. Arch Iran Med. 2018 Jun 1;21(6):251-259. [Content Brief]
Keywords
