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Cat. No.: HY-112553

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HZ52

HZ52 is a potent, reversible 5-lipoxygenase inhibitor, blocking leukotriene synthesis with an IC₅₀ of 0.7 μM in intact human polymorphonuclear leukocytes.

For research use only. We do not sell to patients.

CAS No.: 1077626-51-7
Formula: C₂₄H₂₆ClN₃O₂S
Molecular Weight:456.00

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

HZ52 Chemical Structure

CAS No.: 1077626-51-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
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Bioz

Biological Activity

Description

HZ52 is a potent, reversible 5-lipoxygenase inhibitor, blocking leukotriene synthesis with an IC₅₀ of 0.7 μM in intact human polymorphonuclear leukocytes^[1].

All Lipoxygenase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	1.6 μM Compound: 7a	Inhibition of PGES1 in human A549 cell microsome assessed as PGE2 formation by cell-free assay Inhibition of PGES1 in human A549 cell microsome assessed as PGE2 formation by cell-free assay	[PMID: 19053751]
PMNL	IC₅₀	0.7 μM Compound: 7a	Inhibition of 5-LO in PMNL cells Inhibition of 5-LO in PMNL cells	[PMID: 19053751]

Chemical Information

CAS No. 1077626-51-7
Molecular Weight 456.00
Formula C₂₄H₂₆ClN₃O₂S
SMILES

ClC1=CC(NC2=CC=C(C=C2)C3=CC=CC=C3)=NC(SC(C(O)=O)CCCCCC)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Greiner C, et al. 2-(4-(Biphenyl-4-ylamino)-6-chloropyrimidin-2-ylthio)octanoic acid (HZ52)--a novel type of 5-lipoxygenase inhibitor with favourable molecular pharmacology and efficacy in vivo. Br J Pharmacol. 2011 Sep;164(2b):781-93. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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HZ52

High-Throughput Bioactive Compound Library

All Lipoxygenase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

HZ52 Related Classifications

HY-112553 Related Classifications